Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55′668 deaths in 114′491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of dea...

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Detalles Bibliográficos
Autores: Styczyński, Jan, Tridello, Gloria, Koster, Linda, Iacobelli, Simona, van Biezen, Anja, van der Werf, Steffie, Mikulska, Małgorzata, Gil, Lidia, Cordonnier, Catherine, Ljungman, Per, Averbuch, Diana, Cesaro, Simone, Cámara, Rafael de la, Baldomero, Helen, Bader, Peter, Basak, Grzegorz, Bonini, Chiara, Duarte Palomino, Rafael, Dufour, Carlo, Kuball, Jurgen, Lankester, Arjan, Montoto, Silvia, Nagler, Arnon, Snowden, John A., Kröger, Nicolaus, Mohty, Mohamad, Gratwohl, Alois
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/694707
Acceso en línea:http://hdl.handle.net/10486/694707
https://dx.doi.org/10.1038/s41409-019-0624-z
Access Level:acceso abierto
Palabra clave:Haematopoietic stem cell transplantation (HSCT)
Death
Leukemia
Infections
Medicina
Descripción
Sumario:Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55′668 deaths in 114′491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980–2001) to cohort 2 (2002–2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of “unknown origin”.

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