Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota

Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting infl...

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Bibliographic Details
Authors: Drumo, Rosanna, Pesciaroli, Michele, Ruggeri, Jessica, Tarantino, Michela, Chirullo, Barbara, Pistoia, Claudia, Petrucci, Paola, Martinelli, Nicola, Moscati, Livia, Manuali, Elisabetta, Pavone, Silvia, Picciolini, Matteo, Ammendola, Serena, Gabai, Gianfranco, Battistoni, Andrea, Pezzotti, Giovanni, Alborali, Giovanni L, Napolioni, Valerio, Pasquali, Paolo, Magistrali, Chiara F
Format: article
Publication Date:2015
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/35264
Online Access:https://hdl.handle.net/20.500.14352/35264
Access Level:Open access
Keyword:Salmonella Typhimurium
microbiota
inflammation
immune response
pig
salmonellosis
Veterinaria
3109 Ciencias Veterinarias
Description
Summary:Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota.

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