Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner

Inhibiting M1 microglia phenotype while stimulating the M2 microglia has been suggested as a potential therapeutic approach for the treatment of neuroinflammatory diseases. Our hypothesis is that the type of dietary fatty acids (FAs) into human postprandial triglyceride-rich lipoproteins (TRLs) coul...

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Autores: Toscano Sánchez, María del Rocío, Millán Linares, María del Carmen, Lemus Conejo, Ana, Claro Cala, Carmen María, Sánchez Margalet, Víctor, Montserrat de la Paz, Sergio
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/166831
Acceso en línea:https://hdl.handle.net/11441/166831
https://doi.org/10.1016/j.jnutbio.2019.108248
Access Level:acceso abierto
Palabra clave:Postprandial metabolism
Microglia
Obesity
Olive oil
Fatty acids
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spelling Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent mannerToscano Sánchez, María del RocíoMillán Linares, María del CarmenLemus Conejo, AnaClaro Cala, Carmen MaríaSánchez Margalet, VíctorMontserrat de la Paz, SergioPostprandial metabolismMicrogliaObesityOlive oilFatty acidsInhibiting M1 microglia phenotype while stimulating the M2 microglia has been suggested as a potential therapeutic approach for the treatment of neuroinflammatory diseases. Our hypothesis is that the type of dietary fatty acids (FAs) into human postprandial triglyceride-rich lipoproteins (TRLs) could modulate the plasticity of microglia. We isolated TRLs at the postprandial hypertriglyceridemic peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated FAs (SFAs), monounsaturated FAs (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated FAs. We observed that postprandial TRL-MUFAs enhance M2 microglia polarization, whereas postprandial TRL-SFAs made polarized microglia prone to an M1 phenotype. In addition, in contrast to dietary SFAs, dietary MUFAs primed for a reduced proinflammatory profile in the brain of mice fed with the different FA-enriched diets. Our study underlines a role of postprandial TRLs as a metabolic entity in regulating the plasticity of microglia and brings an understanding of the mechanisms by which dietary FAs are environmental factors fostering the innate immune responsiveness. These exciting findings open opportunities for developing nutraceutical strategies with olive oil as the principal source of MUFAs, notably oleic acid, to prevent development and progression of neuroinflammation-related diseases.Elsevier Science IncFarmacología, Pediatría y RadiologíaBioquímica Médica y Biología Molecular e InmunologíaInstituto de Biomedicina de Sevilla (IBIS)2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/166831https://doi.org/10.1016/j.jnutbio.2019.108248reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)Inglésnullhttps://www.sciencedirect.com/science/article/pii/S0955286319302657?via=ihubinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1668312026-06-17T12:51:07Z
dc.title.none.fl_str_mv Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
title Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
spellingShingle Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
Toscano Sánchez, María del Rocío
Postprandial metabolism
Microglia
Obesity
Olive oil
Fatty acids
title_short Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
title_full Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
title_fullStr Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
title_full_unstemmed Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
title_sort Postprandial triglyceride-rich lipoproteins promote M1/M2 microglia polarization in a fatty-acid-dependent manner
dc.creator.none.fl_str_mv Toscano Sánchez, María del Rocío
Millán Linares, María del Carmen
Lemus Conejo, Ana
Claro Cala, Carmen María
Sánchez Margalet, Víctor
Montserrat de la Paz, Sergio
author Toscano Sánchez, María del Rocío
author_facet Toscano Sánchez, María del Rocío
Millán Linares, María del Carmen
Lemus Conejo, Ana
Claro Cala, Carmen María
Sánchez Margalet, Víctor
Montserrat de la Paz, Sergio
author_role author
author2 Millán Linares, María del Carmen
Lemus Conejo, Ana
Claro Cala, Carmen María
Sánchez Margalet, Víctor
Montserrat de la Paz, Sergio
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Farmacología, Pediatría y Radiología
Bioquímica Médica y Biología Molecular e Inmunología
Instituto de Biomedicina de Sevilla (IBIS)
dc.subject.none.fl_str_mv Postprandial metabolism
Microglia
Obesity
Olive oil
Fatty acids
topic Postprandial metabolism
Microglia
Obesity
Olive oil
Fatty acids
description Inhibiting M1 microglia phenotype while stimulating the M2 microglia has been suggested as a potential therapeutic approach for the treatment of neuroinflammatory diseases. Our hypothesis is that the type of dietary fatty acids (FAs) into human postprandial triglyceride-rich lipoproteins (TRLs) could modulate the plasticity of microglia. We isolated TRLs at the postprandial hypertriglyceridemic peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated FAs (SFAs), monounsaturated FAs (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated FAs. We observed that postprandial TRL-MUFAs enhance M2 microglia polarization, whereas postprandial TRL-SFAs made polarized microglia prone to an M1 phenotype. In addition, in contrast to dietary SFAs, dietary MUFAs primed for a reduced proinflammatory profile in the brain of mice fed with the different FA-enriched diets. Our study underlines a role of postprandial TRLs as a metabolic entity in regulating the plasticity of microglia and brings an understanding of the mechanisms by which dietary FAs are environmental factors fostering the innate immune responsiveness. These exciting findings open opportunities for developing nutraceutical strategies with olive oil as the principal source of MUFAs, notably oleic acid, to prevent development and progression of neuroinflammation-related diseases.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/166831
https://doi.org/10.1016/j.jnutbio.2019.108248
url https://hdl.handle.net/11441/166831
https://doi.org/10.1016/j.jnutbio.2019.108248
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv null
https://www.sciencedirect.com/science/article/pii/S0955286319302657?via=ihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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