Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.

Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled w...

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Detalles Bibliográficos
Autores: Erny, Guillaume L., Cifuentes, Alejandro
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/12149
Acceso en línea:http://hdl.handle.net/10261/12149
Access Level:acceso abierto
Palabra clave:Biological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
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spelling Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.Erny, Guillaume L.Cifuentes, AlejandroBiological fluidsLC–MSCE–MSEnantiomersDrugsCapillary electrophoresisHyphenated techniquesLiquid chromatographyMetabolitesSample preparationCEC–MSDetermination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including e.g., antiinflammatories, antihypertensives, relaxants, etc, by liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc) are also discussed.Peer reviewedElsevier200920092006info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501163062 bytesapplication/pdfhttp://hdl.handle.net/10261/12149reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.jpba.2005.10.044info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/121492026-05-22T06:33:51Z
dc.title.none.fl_str_mv Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
title Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
spellingShingle Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
Erny, Guillaume L.
Biological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
title_short Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
title_full Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
title_fullStr Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
title_full_unstemmed Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
title_sort Liquid separation techniques coupled with mass spectrometry for chiral analysis of pharmaceuticals compounds and their metabolites in biological fluids.
dc.creator.none.fl_str_mv Erny, Guillaume L.
Cifuentes, Alejandro
author Erny, Guillaume L.
author_facet Erny, Guillaume L.
Cifuentes, Alejandro
author_role author
author2 Cifuentes, Alejandro
author2_role author
dc.subject.none.fl_str_mv Biological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
topic Biological fluids
LC–MS
CE–MS
Enantiomers
Drugs
Capillary electrophoresis
Hyphenated techniques
Liquid chromatography
Metabolites
Sample preparation
CEC–MS
description Determination of the chiral composition of drugs is nowadays a key step in order to determine purity, activity, bioavailability, biodegradation, etc, of pharmaceuticals. In this manuscript, works published for the last 5 years on the analysis of chiral drugs by liquid separation techniques coupled with mass spectrometry are reviewed. Namely, chiral analysis of pharmaceuticals including e.g., antiinflammatories, antihypertensives, relaxants, etc, by liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry are included. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc) are also discussed.
publishDate 2006
dc.date.none.fl_str_mv 2006
2009
2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/12149
url http://hdl.handle.net/10261/12149
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.jpba.2005.10.044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 163062 bytes
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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