Heterogeneity of DNA damage incidence and repair in different chromatin contexts

It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, whi...

ver descrição completa

Detalhes bibliográficos
Autores: Ortega Moreno, Pedro, Gómez González, Belén, Aguilera López, Andrés
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/125272
Acesso em linha:https://hdl.handle.net/11441/125272
https://doi.org/10.1016/j.dnarep.2021.103210
Access Level:acceso abierto
Palavra-chave:Chromatin
DNA damage
DNA repair
Double-strand break
Genome instability
id ES_121abdc65227e2572f93d8c5caaf3b6f
oai_identifier_str oai:idus.us.es:11441/125272
network_acronym_str ES
network_name_str España
repository_id_str
spelling Heterogeneity of DNA damage incidence and repair in different chromatin contextsOrtega Moreno, PedroGómez González, BelénAguilera López, AndrésChromatinDNA damageDNA repairDouble-strand breakGenome instabilityIt has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.ElsevierGenética2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/125272https://doi.org/10.1016/j.dnarep.2021.103210reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésDNA Repair, 107, 103210.https://doi.org/10.1016/j.dnarep.2021.103210info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1252722026-06-17T12:51:07Z
dc.title.none.fl_str_mv Heterogeneity of DNA damage incidence and repair in different chromatin contexts
title Heterogeneity of DNA damage incidence and repair in different chromatin contexts
spellingShingle Heterogeneity of DNA damage incidence and repair in different chromatin contexts
Ortega Moreno, Pedro
Chromatin
DNA damage
DNA repair
Double-strand break
Genome instability
title_short Heterogeneity of DNA damage incidence and repair in different chromatin contexts
title_full Heterogeneity of DNA damage incidence and repair in different chromatin contexts
title_fullStr Heterogeneity of DNA damage incidence and repair in different chromatin contexts
title_full_unstemmed Heterogeneity of DNA damage incidence and repair in different chromatin contexts
title_sort Heterogeneity of DNA damage incidence and repair in different chromatin contexts
dc.creator.none.fl_str_mv Ortega Moreno, Pedro
Gómez González, Belén
Aguilera López, Andrés
author Ortega Moreno, Pedro
author_facet Ortega Moreno, Pedro
Gómez González, Belén
Aguilera López, Andrés
author_role author
author2 Gómez González, Belén
Aguilera López, Andrés
author2_role author
author
dc.contributor.none.fl_str_mv Genética
dc.subject.none.fl_str_mv Chromatin
DNA damage
DNA repair
Double-strand break
Genome instability
topic Chromatin
DNA damage
DNA repair
Double-strand break
Genome instability
description It has been long known that some regions of the genome are more susceptible to damage and mutagenicity than others. Recent advances have determined a critical role of chromatin both in the incidence of damage and in its repair. Thus, chromatin arises as a guardian of the stability of the genome, which is altered in cancer cells. In this review, we focus into the mechanisms by which chromatin influences the occurrence and repair of the most cytotoxic DNA lesions, double-strand breaks, in particular at actively transcribed chromatin or related to DNA replication.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/125272
https://doi.org/10.1016/j.dnarep.2021.103210
url https://hdl.handle.net/11441/125272
https://doi.org/10.1016/j.dnarep.2021.103210
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv DNA Repair, 107, 103210.
https://doi.org/10.1016/j.dnarep.2021.103210
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403600407494656
score 15,301629

Registos relacionados