Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Background: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods: We studied gut microbiome composition and functionality, and plasma and faecal meta...

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Detalhes bibliográficos
Autores: Arnoriaga Rodríguez, María, Mayneris Perxachs, Jordi, Contreras Rodríguez, Oren, Burokas, Aurelijus, Ortega Sanchez, Juan Antonio, Blasco, Gerard, Coll, Claudia, Biarnés, Carles, Castells Nobau, Anna, Puig, Josep, Garre Olmo, Josep, Ramos, Rafel, Pedraza, Salvador, Brugada, Ramon, Vilanova, Joan C., Serena, Joaquín, Barretina, Jordi, Gich, Jordi, Pérez Brocal, Vicente, Moya, Andrés, Fernández Real, Xavier, Ramio Torrentà, Lluís, Pamplona, Reinald, Sol, Joaquim, Jové, Mariona, Ricart, Wifredo, Portero-Otin, Manuel, Maldonado, Rafael, 1961-, Fernández Real, Jose Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/181711
Acesso em linha:https://hdl.handle.net/2445/181711
Access Level:acceso abierto
Palavra-chave:Obesitat
Microbiologia
Obesity
Microbiology
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spelling Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathwaysArnoriaga Rodríguez, MaríaMayneris Perxachs, JordiContreras Rodríguez, OrenBurokas, AurelijusOrtega Sanchez, Juan AntonioBlasco, GerardColl, ClaudiaBiarnés, CarlesCastells Nobau, AnnaPuig, JosepGarre Olmo, JosepRamos, RafelPedraza, SalvadorBrugada, RamonVilanova, Joan C.Serena, JoaquínBarretina, JordiGich, JordiPérez Brocal, VicenteMoya, AndrésFernández Real, XavierRamio Torrentà, LluísPamplona, ReinaldSol, JoaquimJové, MarionaRicart, WifredoPortero-Otin, ManuelMaldonado, Rafael, 1961-Fernández Real, Jose ManuelObesitatMicrobiologiaObesityMicrobiologyBackground: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods: We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results: An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice. Conclusion: These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.BMJ2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/181711Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1136/gutjnl-2020-323371Gut, 2021, vol. 70, num. 12, p. 2283-2296https://doi.org/10.1136/gutjnl-2020-323371info:eu-repo/grantAgreement/EC/FP7/602891cc by-nc (c) Arnoriaga Rodríguez, María et al, 2021http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1817112026-05-27T06:46:51Z
dc.title.none.fl_str_mv Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
spellingShingle Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
Arnoriaga Rodríguez, María
Obesitat
Microbiologia
Obesity
Microbiology
title_short Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_full Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_fullStr Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_full_unstemmed Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
title_sort Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways
dc.creator.none.fl_str_mv Arnoriaga Rodríguez, María
Mayneris Perxachs, Jordi
Contreras Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco, Gerard
Coll, Claudia
Biarnés, Carles
Castells Nobau, Anna
Puig, Josep
Garre Olmo, Josep
Ramos, Rafel
Pedraza, Salvador
Brugada, Ramon
Vilanova, Joan C.
Serena, Joaquín
Barretina, Jordi
Gich, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández Real, Xavier
Ramio Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero-Otin, Manuel
Maldonado, Rafael, 1961-
Fernández Real, Jose Manuel
author Arnoriaga Rodríguez, María
author_facet Arnoriaga Rodríguez, María
Mayneris Perxachs, Jordi
Contreras Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco, Gerard
Coll, Claudia
Biarnés, Carles
Castells Nobau, Anna
Puig, Josep
Garre Olmo, Josep
Ramos, Rafel
Pedraza, Salvador
Brugada, Ramon
Vilanova, Joan C.
Serena, Joaquín
Barretina, Jordi
Gich, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández Real, Xavier
Ramio Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero-Otin, Manuel
Maldonado, Rafael, 1961-
Fernández Real, Jose Manuel
author_role author
author2 Mayneris Perxachs, Jordi
Contreras Rodríguez, Oren
Burokas, Aurelijus
Ortega Sanchez, Juan Antonio
Blasco, Gerard
Coll, Claudia
Biarnés, Carles
Castells Nobau, Anna
Puig, Josep
Garre Olmo, Josep
Ramos, Rafel
Pedraza, Salvador
Brugada, Ramon
Vilanova, Joan C.
Serena, Joaquín
Barretina, Jordi
Gich, Jordi
Pérez Brocal, Vicente
Moya, Andrés
Fernández Real, Xavier
Ramio Torrentà, Lluís
Pamplona, Reinald
Sol, Joaquim
Jové, Mariona
Ricart, Wifredo
Portero-Otin, Manuel
Maldonado, Rafael, 1961-
Fernández Real, Jose Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Microbiologia
Obesity
Microbiology
topic Obesitat
Microbiologia
Obesity
Microbiology
description Background: Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods: We studied gut microbiome composition and functionality, and plasma and faecal metabolomics in association with cognitive tests evaluating inhibitory control (Stroop test) and brain structure in a discovery (n=156), both cross-sectionally and longitudinally, and in an independent replication cohort (n=970). Faecal microbiota transplantation (FMT) in mice evaluated the impact on reversal learning and medial prefrontal cortex (mPFC) transcriptomics. Results: An interplay among IC, brain structure (in humans) and mPFC transcriptomics (in mice), plasma/faecal metabolomics and the gut metagenome was found. Obesity-dependent alterations in one-carbon metabolism, tryptophan and histidine pathways were associated with IC in the two independent cohorts. Bacterial functions linked to one-carbon metabolism (thyX,dut, exodeoxyribonuclease V), and the anterior cingulate cortex volume were associated with IC, cross-sectionally and longitudinally. FMT from individuals with obesity led to alterations in mice reversal learning. In an independent FMT experiment, human donor's bacterial functions related to IC deficits were associated with mPFC expression of one-carbon metabolism-related genes of recipient's mice. Conclusion: These results highlight the importance of targeting obesity-related impulsive behaviour through the induction of gut microbiota shifts.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181711
url https://hdl.handle.net/2445/181711
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1136/gutjnl-2020-323371
Gut, 2021, vol. 70, num. 12, p. 2283-2296
https://doi.org/10.1136/gutjnl-2020-323371
info:eu-repo/grantAgreement/EC/FP7/602891
dc.rights.none.fl_str_mv cc by-nc (c) Arnoriaga Rodríguez, María et al, 2021
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Arnoriaga Rodríguez, María et al, 2021
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ
publisher.none.fl_str_mv BMJ
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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