TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps

[EN] TSLP is an alarmin released upon activation of epithelia in response to various external stimuli and is involved in type 2 cytokine-mediated pathological disorders. The formation of a high-affinity heterodimeric receptor complex, comprising the thymic stromal lymphopoietin receptor (TSLPR) chai...

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Autores: Moreno Jiménez, Emma, Morgado Llamazares, Natalia, Gómez-García, Manuel, Sanz Lozano, Catalina Sofía, Gil Melcón, María, Isidoro García, María, Dávila González, Ignacio Jesús, García Sánchez, María Asunción
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/168001
Acesso em linha:http://hdl.handle.net/10366/168001
Access Level:acceso abierto
Palavra-chave:TSLP
TSLPR
N-ERD
CRSwNP
biomargene expression
biomarker
nasal polyp
Genetics
Allergy and Immunology
2409 Genética
3207.01 Alergias
2412 Inmunología
alergia e inmunología
genética
id ES_0abaa9e935f42e5192be8b6f1ef9a93a
oai_identifier_str oai:gredos.usal.es:10366/168001
network_acronym_str ES
network_name_str España
repository_id_str
spelling TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal PolypsMoreno Jiménez, EmmaMorgado Llamazares, NataliaGómez-García, ManuelSanz Lozano, Catalina SofíaGil Melcón, MaríaIsidoro García, MaríaDávila González, Ignacio JesúsGarcía Sánchez, María AsunciónTSLPTSLPRN-ERDCRSwNPbiomargene expressionbiomarkernasal polypGeneticsAllergy and Immunology2409 Genética3207.01 Alergias2412 Inmunologíaalergia e inmunologíagenética[EN] TSLP is an alarmin released upon activation of epithelia in response to various external stimuli and is involved in type 2 cytokine-mediated pathological disorders. The formation of a high-affinity heterodimeric receptor complex, comprising the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα, is required for signaling. This study investigated whether TSLP and TSLPR expression in peripheral blood or nasal polyps could provide a valuable approach for the molecular phenotyping of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The study population comprised 156 unrelated Caucasian individuals, including 45 controls and 111 patients with CRSwNP. Quantitative PCR analysis of TSLP and TSLPR was performed on the population study’s peripheral blood and nasal biopsy. The data were analyzed for potential associations, and possible use as a biomarker was studied. Significant differences were observed in TSLP and TSLPR blood expression between the control group and patients. Similarly, the expression of TSLP observed in biopsy samples was statistically significantly elevated in the polyp tissue of the patient compared with healthy controls. The combination of TSLP and TSLPR expression testing with peripheral blood eosinophils represents a more specific biomarker in patients exhibiting low eosinophil values. Further investigation of TSLP/TSLPR mRNA levels in peripheral blood may yield new minimally invasive biomarkers.Instituto de Salud Carlos III (ISCIII); European Union; European Union-NextGeneration EU, Mecanismo para la Recuperación y la Resiliencia (MRR); Junta de Castilla y León; Spanish Ministry of Education.MDPI202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/168001reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1680012026-06-07T06:28:51Z
dc.title.none.fl_str_mv TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
title TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
spellingShingle TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
Moreno Jiménez, Emma
TSLP
TSLPR
N-ERD
CRSwNP
biomargene expression
biomarker
nasal polyp
Genetics
Allergy and Immunology
2409 Genética
3207.01 Alergias
2412 Inmunología
alergia e inmunología
genética
title_short TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
title_full TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
title_fullStr TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
title_full_unstemmed TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
title_sort TSLP and TSLPR Expression Levels in Peripheral Blood as Potential Biomarkers in Patients with Chronic Rhinosinusitis with Nasal Polyps
dc.creator.none.fl_str_mv Moreno Jiménez, Emma
Morgado Llamazares, Natalia
Gómez-García, Manuel
Sanz Lozano, Catalina Sofía
Gil Melcón, María
Isidoro García, María
Dávila González, Ignacio Jesús
García Sánchez, María Asunción
author Moreno Jiménez, Emma
author_facet Moreno Jiménez, Emma
Morgado Llamazares, Natalia
Gómez-García, Manuel
Sanz Lozano, Catalina Sofía
Gil Melcón, María
Isidoro García, María
Dávila González, Ignacio Jesús
García Sánchez, María Asunción
author_role author
author2 Morgado Llamazares, Natalia
Gómez-García, Manuel
Sanz Lozano, Catalina Sofía
Gil Melcón, María
Isidoro García, María
Dávila González, Ignacio Jesús
García Sánchez, María Asunción
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TSLP
TSLPR
N-ERD
CRSwNP
biomargene expression
biomarker
nasal polyp
Genetics
Allergy and Immunology
2409 Genética
3207.01 Alergias
2412 Inmunología
alergia e inmunología
genética
topic TSLP
TSLPR
N-ERD
CRSwNP
biomargene expression
biomarker
nasal polyp
Genetics
Allergy and Immunology
2409 Genética
3207.01 Alergias
2412 Inmunología
alergia e inmunología
genética
description [EN] TSLP is an alarmin released upon activation of epithelia in response to various external stimuli and is involved in type 2 cytokine-mediated pathological disorders. The formation of a high-affinity heterodimeric receptor complex, comprising the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα, is required for signaling. This study investigated whether TSLP and TSLPR expression in peripheral blood or nasal polyps could provide a valuable approach for the molecular phenotyping of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The study population comprised 156 unrelated Caucasian individuals, including 45 controls and 111 patients with CRSwNP. Quantitative PCR analysis of TSLP and TSLPR was performed on the population study’s peripheral blood and nasal biopsy. The data were analyzed for potential associations, and possible use as a biomarker was studied. Significant differences were observed in TSLP and TSLPR blood expression between the control group and patients. Similarly, the expression of TSLP observed in biopsy samples was statistically significantly elevated in the polyp tissue of the patient compared with healthy controls. The combination of TSLP and TSLPR expression testing with peripheral blood eosinophils represents a more specific biomarker in patients exhibiting low eosinophil values. Further investigation of TSLP/TSLPR mRNA levels in peripheral blood may yield new minimally invasive biomarkers.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/168001
url http://hdl.handle.net/10366/168001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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