Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis

Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to...

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Autores: Forte, Maria Florencia, Oliva, Vincenzo, De Prisco, Michele, Garriga, Marina, Bitanihirwe, Byron, Alameda, Luis, Gonzalez Segura, Àlex, Vieta i Pascual, Eduard, 1963-, Baeza, Inmaculada, 1970-, Parellada Rodón, Eduard, Penadés Rubio, Rafael, Ramos Quiroga, Josep Antoni, Amoretti Guadall, Silvia, Mezquida Mateos, Gisela, García Rizo, Clemente
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219486
Acesso em linha:https://hdl.handle.net/2445/219486
Access Level:acceso abierto
Palavra-chave:Complicacions en el part
Psicopatologia infantil
Metaanàlisi
Esquizofrènia
Psicosi
Labor complications (Obstetrics)
Child psychopathology
Meta-analysis
Schizophrenia
Psychoses
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spelling Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysisForte, Maria FlorenciaOliva, VincenzoDe Prisco, MicheleGarriga, MarinaBitanihirwe, ByronAlameda, LuisGonzalez Segura, ÀlexVieta i Pascual, Eduard, 1963-Baeza, Inmaculada, 1970-Parellada Rodón, EduardPenadés Rubio, RafaelRamos Quiroga, Josep AntoniAmoretti Guadall, SilviaMezquida Mateos, GiselaGarcía Rizo, ClementeComplicacions en el partPsicopatologia infantilMetaanàlisiEsquizofrèniaPsicosiLabor complications (Obstetrics)Child psychopathologyMeta-analysisSchizophreniaPsychosesSchizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to comprehensively evaluate differences in psychopathology between individuals with and without exposure to OCs in relation to SZ and related disorders. We systematically searched PubMed, PsycINFO, and SCOPUS to identify eligible studies. A total of 4091 records were retrieved through systematic and citation searches. 14 studies were included in the review, and 12 met the criteria for meta-analysis, involving 2992 patients. The analysis revealed that SZ patients who had been exposed to OCs exhibited significantly higher levels of positive symptoms (SMD=0.10, 95 %CI=0.01,0.20; p=0.03), general psychopathology (SMD=0.37, 95 %CI=0.22,0.52; p<0.001), total clinical symptomatology (SMD=0.44, 95 %CI=0.24,0.64; p<0.001) and depressive symptoms (SMD=0.47, 95 %CI=0.09,0.84; p=0.01). No significant differences were found in negative symptomatology and functioning. Our results suggest that OCs are not only associated with an increased risk of developing psychosis but with more severe symptomatology.Elsevier2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/219486Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2024.105913Neuroscience and Biobehavioral Reviews, 2024, vol. 167https://doi.org/10.1016/j.neubiorev.2024.105913cc-by-nc (c) Forte, Maria Florencia et al., 2024http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2194862026-05-29T05:05:01Z
dc.title.none.fl_str_mv Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
title Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
spellingShingle Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
Forte, Maria Florencia
Complicacions en el part
Psicopatologia infantil
Metaanàlisi
Esquizofrènia
Psicosi
Labor complications (Obstetrics)
Child psychopathology
Meta-analysis
Schizophrenia
Psychoses
title_short Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
title_full Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
title_fullStr Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
title_full_unstemmed Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
title_sort Obstetric complications and psychopathology in schizophrenia: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Forte, Maria Florencia
Oliva, Vincenzo
De Prisco, Michele
Garriga, Marina
Bitanihirwe, Byron
Alameda, Luis
Gonzalez Segura, Àlex
Vieta i Pascual, Eduard, 1963-
Baeza, Inmaculada, 1970-
Parellada Rodón, Eduard
Penadés Rubio, Rafael
Ramos Quiroga, Josep Antoni
Amoretti Guadall, Silvia
Mezquida Mateos, Gisela
García Rizo, Clemente
author Forte, Maria Florencia
author_facet Forte, Maria Florencia
Oliva, Vincenzo
De Prisco, Michele
Garriga, Marina
Bitanihirwe, Byron
Alameda, Luis
Gonzalez Segura, Àlex
Vieta i Pascual, Eduard, 1963-
Baeza, Inmaculada, 1970-
Parellada Rodón, Eduard
Penadés Rubio, Rafael
Ramos Quiroga, Josep Antoni
Amoretti Guadall, Silvia
Mezquida Mateos, Gisela
García Rizo, Clemente
author_role author
author2 Oliva, Vincenzo
De Prisco, Michele
Garriga, Marina
Bitanihirwe, Byron
Alameda, Luis
Gonzalez Segura, Àlex
Vieta i Pascual, Eduard, 1963-
Baeza, Inmaculada, 1970-
Parellada Rodón, Eduard
Penadés Rubio, Rafael
Ramos Quiroga, Josep Antoni
Amoretti Guadall, Silvia
Mezquida Mateos, Gisela
García Rizo, Clemente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Complicacions en el part
Psicopatologia infantil
Metaanàlisi
Esquizofrènia
Psicosi
Labor complications (Obstetrics)
Child psychopathology
Meta-analysis
Schizophrenia
Psychoses
topic Complicacions en el part
Psicopatologia infantil
Metaanàlisi
Esquizofrènia
Psicosi
Labor complications (Obstetrics)
Child psychopathology
Meta-analysis
Schizophrenia
Psychoses
description Schizophrenia (SZ) is a severe mental health condition involving gene-environment interactions, with obstetric complications (OCs) conferring an elevated risk for the disease. Current research suggests that OCs may exacerbate SZ symptoms. This study conducted a systematic review and meta-analysis to comprehensively evaluate differences in psychopathology between individuals with and without exposure to OCs in relation to SZ and related disorders. We systematically searched PubMed, PsycINFO, and SCOPUS to identify eligible studies. A total of 4091 records were retrieved through systematic and citation searches. 14 studies were included in the review, and 12 met the criteria for meta-analysis, involving 2992 patients. The analysis revealed that SZ patients who had been exposed to OCs exhibited significantly higher levels of positive symptoms (SMD=0.10, 95 %CI=0.01,0.20; p=0.03), general psychopathology (SMD=0.37, 95 %CI=0.22,0.52; p<0.001), total clinical symptomatology (SMD=0.44, 95 %CI=0.24,0.64; p<0.001) and depressive symptoms (SMD=0.47, 95 %CI=0.09,0.84; p=0.01). No significant differences were found in negative symptomatology and functioning. Our results suggest that OCs are not only associated with an increased risk of developing psychosis but with more severe symptomatology.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219486
url https://hdl.handle.net/2445/219486
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neubiorev.2024.105913
Neuroscience and Biobehavioral Reviews, 2024, vol. 167
https://doi.org/10.1016/j.neubiorev.2024.105913
dc.rights.none.fl_str_mv cc-by-nc (c) Forte, Maria Florencia et al., 2024
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Forte, Maria Florencia et al., 2024
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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