Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task

Background. A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction er...

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Autores: Fuentes-Claramonte P, Garcia-Leon MA, Salgado-Pineda P, Ramiro N, Soler-Vidal J, Torres ML, Cano R, Argila-Plaza I, Panicali F, Sarri C, Jaurrieta N, Sánchez M, Boix-Quintana E, Albacete A, Maristany T, Sarró S, Raduà J, McKenna PJ, Salvador R, Pomarol-Clotet E
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Fundació Sant Joan de Déu
Repositório:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p23064
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23064
Access Level:Acceso aberto
Palavra-chave:fMRI
negative symptoms
psychosis
reinforcement learning
reward prediction error
reward
schizophrenia
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spelling Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) taskFuentes-Claramonte PGarcia-Leon MASalgado-Pineda PRamiro NSoler-Vidal JTorres MLCano RArgila-Plaza IPanicali FSarri CJaurrieta NSánchez MBoix-Quintana EAlbacete AMaristany TSarró SRaduà JMcKenna PJSalvador RPomarol-Clotet EfMRInegative symptomspsychosisreinforcement learningreward prediction errorrewardschizophreniaBackground. A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations. Methods. Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Results. In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI. Conclusions. The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex.CAMBRIDGE UNIV PRESS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23064PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p230642026-05-27T12:37:41Z
dc.title.none.fl_str_mv Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
title Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
spellingShingle Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
Fuentes-Claramonte P
fMRI
negative symptoms
psychosis
reinforcement learning
reward prediction error
reward
schizophrenia
title_short Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
title_full Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
title_fullStr Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
title_full_unstemmed Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
title_sort Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
dc.creator.none.fl_str_mv Fuentes-Claramonte P
Garcia-Leon MA
Salgado-Pineda P
Ramiro N
Soler-Vidal J
Torres ML
Cano R
Argila-Plaza I
Panicali F
Sarri C
Jaurrieta N
Sánchez M
Boix-Quintana E
Albacete A
Maristany T
Sarró S
Raduà J
McKenna PJ
Salvador R
Pomarol-Clotet E
author Fuentes-Claramonte P
author_facet Fuentes-Claramonte P
Garcia-Leon MA
Salgado-Pineda P
Ramiro N
Soler-Vidal J
Torres ML
Cano R
Argila-Plaza I
Panicali F
Sarri C
Jaurrieta N
Sánchez M
Boix-Quintana E
Albacete A
Maristany T
Sarró S
Raduà J
McKenna PJ
Salvador R
Pomarol-Clotet E
author_role author
author2 Garcia-Leon MA
Salgado-Pineda P
Ramiro N
Soler-Vidal J
Torres ML
Cano R
Argila-Plaza I
Panicali F
Sarri C
Jaurrieta N
Sánchez M
Boix-Quintana E
Albacete A
Maristany T
Sarró S
Raduà J
McKenna PJ
Salvador R
Pomarol-Clotet E
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv fMRI
negative symptoms
psychosis
reinforcement learning
reward prediction error
reward
schizophrenia
topic fMRI
negative symptoms
psychosis
reinforcement learning
reward prediction error
reward
schizophrenia
description Background. A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations. Methods. Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE. Results. In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI. Conclusions. The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23064
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=23064
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv PSYCHOLOGICAL MEDICINE
ISSN: 00332917
ISSNe: 14698978
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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