Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

[Usage Notes] Cochlear gene expression, MKPs and MAPK Figure1 - Source Data 1.xlsx Hearing measurements of wild type and Mkp1 deficient mice Figure2 - Source Data 1.xlsx Cochlear gene expression, cell markers Figure3 - Source Data 1.xlsx Cochlear gene expression, oxidative stress markers Figure5 - S...

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Authors: Celaya, Adelaida M., Sánchez-Pérez, Isabel, Bermúdez-Muñoz, Jose Mª, Rodriguez-de la Rosa, Lourdes, Pintado-Berninches, Laura, Perona Abellón, Rosario, Murillo-Cuesta, Silvia, Varela-Nieto, Isabel
Format: conjunto de datos
Publication Date:2019
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/283785
Online Access:http://hdl.handle.net/10261/283785
http://datadryad.org/stash/dataset/doi:10.5061/dryad.51m8c58
Access Level:Open access
Keyword:Mus musculus
Hearing
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing lossCelaya, Adelaida M.Sánchez-Pérez, IsabelBermúdez-Muñoz, Jose MªRodriguez-de la Rosa, LourdesPintado-Berninches, LauraPerona Abellón, RosarioMurillo-Cuesta, SilviaVarela-Nieto, IsabelMus musculusHearing[Usage Notes] Cochlear gene expression, MKPs and MAPK Figure1 - Source Data 1.xlsx Hearing measurements of wild type and Mkp1 deficient mice Figure2 - Source Data 1.xlsx Cochlear gene expression, cell markers Figure3 - Source Data 1.xlsx Cochlear gene expression, oxidative stress markers Figure5 - Source Data 1.xlsx Cochlear gene expression, inflammation markers Figure6 - Source Data 1.xlsxMitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-described elements of the response to otic injury and the otoprotective potential of JNK inhibitors is being tested in clinical trials. In contrast, there are no studies exploring the role of DUSP1 in hearing and hearing loss. Here we show that Dusp1 expression is age-regulated in the mouse cochlea. Dusp1 gene knock-out caused premature progressive hearing loss, as confirmed by auditory evoked responses in Dusp1-/- mice. Hearing loss correlated with cell death in hair cells, degeneration of spiral neurons and increased macrophage infiltration. Dusp1-/- mouse cochleae showed imbalanced redox status and deregulated expression of cytokines. These data suggest that DUSP1 is essential for cochlear homeostasis in the response to stress during ageing.Peer reviewedDryadConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222019info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1xlsxhttp://hdl.handle.net/10261/283785http://datadryad.org/stash/dataset/doi:10.5061/dryad.51m8c58reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCelaya, Adelaida M.; Sánchez-Pérez, Isabel; Bermúdez-Muñoz, Jose Mª; Rodriguez-de la Rosa, Lourdes; Pintado-Berninches, Laura; Perona Abellón, Rosario; Murillo-Cuesta, Silvia; Varela-Nieto, Isabel. Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. eLife 8: e39159 (2019). https://doi.org/10.7554/eLife.39159 . http://hdl.handle.net/10261/188724https://doi.org/10.5061/dryad.51m8c58Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2837852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
title Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
spellingShingle Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
Celaya, Adelaida M.
Mus musculus
Hearing
title_short Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
title_full Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
title_fullStr Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
title_full_unstemmed Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
title_sort Data from: Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
dc.creator.none.fl_str_mv Celaya, Adelaida M.
Sánchez-Pérez, Isabel
Bermúdez-Muñoz, Jose Mª
Rodriguez-de la Rosa, Lourdes
Pintado-Berninches, Laura
Perona Abellón, Rosario
Murillo-Cuesta, Silvia
Varela-Nieto, Isabel
author Celaya, Adelaida M.
author_facet Celaya, Adelaida M.
Sánchez-Pérez, Isabel
Bermúdez-Muñoz, Jose Mª
Rodriguez-de la Rosa, Lourdes
Pintado-Berninches, Laura
Perona Abellón, Rosario
Murillo-Cuesta, Silvia
Varela-Nieto, Isabel
author_role author
author2 Sánchez-Pérez, Isabel
Bermúdez-Muñoz, Jose Mª
Rodriguez-de la Rosa, Lourdes
Pintado-Berninches, Laura
Perona Abellón, Rosario
Murillo-Cuesta, Silvia
Varela-Nieto, Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mus musculus
Hearing
topic Mus musculus
Hearing
description [Usage Notes] Cochlear gene expression, MKPs and MAPK Figure1 - Source Data 1.xlsx Hearing measurements of wild type and Mkp1 deficient mice Figure2 - Source Data 1.xlsx Cochlear gene expression, cell markers Figure3 - Source Data 1.xlsx Cochlear gene expression, oxidative stress markers Figure5 - Source Data 1.xlsx Cochlear gene expression, inflammation markers Figure6 - Source Data 1.xlsx
publishDate 2019
dc.date.none.fl_str_mv 2019
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/283785
http://datadryad.org/stash/dataset/doi:10.5061/dryad.51m8c58
url http://hdl.handle.net/10261/283785
http://datadryad.org/stash/dataset/doi:10.5061/dryad.51m8c58
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Celaya, Adelaida M.; Sánchez-Pérez, Isabel; Bermúdez-Muñoz, Jose Mª; Rodriguez-de la Rosa, Lourdes; Pintado-Berninches, Laura; Perona Abellón, Rosario; Murillo-Cuesta, Silvia; Varela-Nieto, Isabel. Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. eLife 8: e39159 (2019). https://doi.org/10.7554/eLife.39159 . http://hdl.handle.net/10261/188724
https://doi.org/10.5061/dryad.51m8c58
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv xlsx
dc.publisher.none.fl_str_mv Dryad
publisher.none.fl_str_mv Dryad
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402988457492480
score 15,812455

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