Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell ad...

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Autores: Cardozo, Marcos Julián, Sánchez-Arrones, Luisa, Sandonis, África, Sánchez-Camacho Blázquez, Cristina, Gestri, Gaia, Wilson, Stephen W., Guerrero, Isabel, Bovolenta, Paola
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/3743
Acesso em linha:http://hdl.handle.net/11268/3743
Access Level:acceso abierto
Palavra-chave:Biological sciences
Developmental biology
Biología
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spelling Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicleCardozo, Marcos JuliánSánchez-Arrones, LuisaSandonis, ÁfricaSánchez-Camacho Blázquez, CristinaGestri, GaiaWilson, Stephen W.Guerrero, IsabelBovolenta, PaolaBiological sciencesDevelopmental biologyBiologíaBiologíaPatterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This receptor complex binds Hh and enhances signalling activation, indicating that Cdon positively regulates the pathway. Here we show that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with a complementary pattern, Cdon acts as a negative Hh signalling regulator. Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hh protein, thereby limiting its dispersion. This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye.20142014-11-2720142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/3743reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/37432026-06-11T12:41:27Z
dc.title.none.fl_str_mv Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
spellingShingle Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
Cardozo, Marcos Julián
Biological sciences
Developmental biology
Biología
Biología
title_short Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_full Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_fullStr Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_full_unstemmed Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
title_sort Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle
dc.creator.none.fl_str_mv Cardozo, Marcos Julián
Sánchez-Arrones, Luisa
Sandonis, África
Sánchez-Camacho Blázquez, Cristina
Gestri, Gaia
Wilson, Stephen W.
Guerrero, Isabel
Bovolenta, Paola
author Cardozo, Marcos Julián
author_facet Cardozo, Marcos Julián
Sánchez-Arrones, Luisa
Sandonis, África
Sánchez-Camacho Blázquez, Cristina
Gestri, Gaia
Wilson, Stephen W.
Guerrero, Isabel
Bovolenta, Paola
author_role author
author2 Sánchez-Arrones, Luisa
Sandonis, África
Sánchez-Camacho Blázquez, Cristina
Gestri, Gaia
Wilson, Stephen W.
Guerrero, Isabel
Bovolenta, Paola
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Biological sciences
Developmental biology
Biología
Biología
topic Biological sciences
Developmental biology
Biología
Biología
description Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This receptor complex binds Hh and enhances signalling activation, indicating that Cdon positively regulates the pathway. Here we show that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with a complementary pattern, Cdon acts as a negative Hh signalling regulator. Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hh protein, thereby limiting its dispersion. This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-11-27
2014
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/3743
url http://hdl.handle.net/11268/3743
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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