The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole

N-3-(1-Methylindol-3-yl)propan-N-(2,2,2-trichloroethoxysulfonyl)guanidine was synthesized from 3-formyl-1-methylindole in six steps and subjected to conditions intended to convert the side-chain into a 2-iminotetrahydropyrimidine- containing product, of relevance to a possible synthesis of the aplic...

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Detalles Bibliográficos
Autores: Pla Queral, Daniel, Mills, Keith, Joule, John A., Albericio Palomera, Fernando, Álvarez Domingo, Mercedes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/62365
Acceso en línea:https://hdl.handle.net/2445/62365
Access Level:acceso abierto
Palabra clave:Síntesi orgànica
Medicaments antineoplàstics
Compostos de nitrogen
Aziridines
Àcids nucleics
Organic synthesis
Antineoplastic agents
Nitrogen compounds
Nucleic acids
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repository_id_str
spelling The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indolePla Queral, DanielMills, KeithJoule, John A.Albericio Palomera, FernandoÁlvarez Domingo, MercedesSíntesi orgànicaMedicaments antineoplàsticsCompostos de nitrogenAziridinesÀcids nucleicsOrganic synthesisAntineoplastic agentsNitrogen compoundsAziridinesNucleic acidsN-3-(1-Methylindol-3-yl)propan-N-(2,2,2-trichloroethoxysulfonyl)guanidine was synthesized from 3-formyl-1-methylindole in six steps and subjected to conditions intended to convert the side-chain into a 2-iminotetrahydropyrimidine- containing product, of relevance to a possible synthesis of the aplicyanins. An alternative reaction course was observed, resulting in the formation of a new tetracyclic system.Michigan Publishing2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/62365Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2009/6/Arkivoc, 2009, vol. 2009, num. 6, p. 260-269cc-by-nc (c) Pla Queral, Daniel et al., 2009http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/623652026-05-27T06:46:51Z
dc.title.none.fl_str_mv The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
title The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
spellingShingle The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
Pla Queral, Daniel
Síntesi orgànica
Medicaments antineoplàstics
Compostos de nitrogen
Aziridines
Àcids nucleics
Organic synthesis
Antineoplastic agents
Nitrogen compounds
Aziridines
Nucleic acids
title_short The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
title_full The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
title_fullStr The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
title_full_unstemmed The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
title_sort The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
dc.creator.none.fl_str_mv Pla Queral, Daniel
Mills, Keith
Joule, John A.
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
author Pla Queral, Daniel
author_facet Pla Queral, Daniel
Mills, Keith
Joule, John A.
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
author_role author
author2 Mills, Keith
Joule, John A.
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
author2_role author
author
author
author
dc.subject.none.fl_str_mv Síntesi orgànica
Medicaments antineoplàstics
Compostos de nitrogen
Aziridines
Àcids nucleics
Organic synthesis
Antineoplastic agents
Nitrogen compounds
Aziridines
Nucleic acids
topic Síntesi orgànica
Medicaments antineoplàstics
Compostos de nitrogen
Aziridines
Àcids nucleics
Organic synthesis
Antineoplastic agents
Nitrogen compounds
Aziridines
Nucleic acids
description N-3-(1-Methylindol-3-yl)propan-N-(2,2,2-trichloroethoxysulfonyl)guanidine was synthesized from 3-formyl-1-methylindole in six steps and subjected to conditions intended to convert the side-chain into a 2-iminotetrahydropyrimidine- containing product, of relevance to a possible synthesis of the aplicyanins. An alternative reaction course was observed, resulting in the formation of a new tetracyclic system.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/62365
url https://hdl.handle.net/2445/62365
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2009/6/
Arkivoc, 2009, vol. 2009, num. 6, p. 260-269
dc.rights.none.fl_str_mv cc-by-nc (c) Pla Queral, Daniel et al., 2009
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Pla Queral, Daniel et al., 2009
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Michigan Publishing
publisher.none.fl_str_mv Michigan Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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