Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels

Ciguatoxins (CTXs) which are produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa and share a ladder-shaped polyether structure, are causative compounds of one of the most frequent foodborne illness disease known as ciguatera fish poisoning (CFP). CFP was initially found in tropical an...

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Detalhes bibliográficos
Autores: Raposo García, Sandra, Louzao Ojeda, María del Carmen, Fuwa, Haruhiko, Sasakin Makoto, Vale González, María del Carmen, Botana López, Luis Miguel
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/44380
Acesso em linha:https://hdl.handle.net/10347/44380
Access Level:acceso abierto
Palavra-chave:Ciguatoxin
Gambierol
Gambierone
44-Methyl gambierone
Sodium channel
3209 Farmacología
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spelling Determination of the toxicity equivalency factors for ciguatoxins using human sodium channelsRaposo García, SandraLouzao Ojeda, María del CarmenFuwa, HaruhikoSasakin MakotoVale González, María del CarmenBotana López, Luis MiguelCiguatoxinGambierolGambierone44-Methyl gambieroneSodium channel3209 FarmacologíaCiguatoxins (CTXs) which are produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa and share a ladder-shaped polyether structure, are causative compounds of one of the most frequent foodborne illness disease known as ciguatera fish poisoning (CFP). CFP was initially found in tropical and subtropical areas but nowadays the dinoflagellates producers of ciguatoxins had spread to European coasts. Therefore, this raises the need of establishing toxicity equivalency factors for the different compounds that can contribute to ciguatera fish poisoning, since biological methods have been replaced by analytical techniques. Thus, in this work, the effects of six compounds causative of ciguatera, on their main target, the human voltage-gated sodium channels have been analyzed for the first time. The results presented here led to the conclusion that the order of potency was CTX1B, CTX3B, CTX4A, gambierol, gambierone and MTX3. Furthermore, the data indicate that the activation voltage of sodium channels is more sensitive to detect ciguatoxins than their effect on the peak sodium current amplitude.ElsevierUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica20222022-01-1220222022-01-12journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/44380reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengAxencia Galega de Innovación Not available ED431C 2021%2F01IISCIII PI19 001248Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID 2020-11262RB-C21EC Interreg Agritox EAPA-998-2018 EUEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 778069-EMERTOXopen accesshttp://purl.org/coar/access_right/c_abf2© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/443802026-06-15T12:47:27Z
dc.title.none.fl_str_mv Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
title Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
spellingShingle Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
Raposo García, Sandra
Ciguatoxin
Gambierol
Gambierone
44-Methyl gambierone
Sodium channel
3209 Farmacología
title_short Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
title_full Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
title_fullStr Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
title_full_unstemmed Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
title_sort Determination of the toxicity equivalency factors for ciguatoxins using human sodium channels
dc.creator.none.fl_str_mv Raposo García, Sandra
Louzao Ojeda, María del Carmen
Fuwa, Haruhiko
Sasakin Makoto
Vale González, María del Carmen
Botana López, Luis Miguel
author Raposo García, Sandra
author_facet Raposo García, Sandra
Louzao Ojeda, María del Carmen
Fuwa, Haruhiko
Sasakin Makoto
Vale González, María del Carmen
Botana López, Luis Miguel
author_role author
author2 Louzao Ojeda, María del Carmen
Fuwa, Haruhiko
Sasakin Makoto
Vale González, María del Carmen
Botana López, Luis Miguel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
dc.subject.none.fl_str_mv Ciguatoxin
Gambierol
Gambierone
44-Methyl gambierone
Sodium channel
3209 Farmacología
topic Ciguatoxin
Gambierol
Gambierone
44-Methyl gambierone
Sodium channel
3209 Farmacología
description Ciguatoxins (CTXs) which are produced by dinoflagellates of the genus Gambierdiscus and Fukuyoa and share a ladder-shaped polyether structure, are causative compounds of one of the most frequent foodborne illness disease known as ciguatera fish poisoning (CFP). CFP was initially found in tropical and subtropical areas but nowadays the dinoflagellates producers of ciguatoxins had spread to European coasts. Therefore, this raises the need of establishing toxicity equivalency factors for the different compounds that can contribute to ciguatera fish poisoning, since biological methods have been replaced by analytical techniques. Thus, in this work, the effects of six compounds causative of ciguatera, on their main target, the human voltage-gated sodium channels have been analyzed for the first time. The results presented here led to the conclusion that the order of potency was CTX1B, CTX3B, CTX4A, gambierol, gambierone and MTX3. Furthermore, the data indicate that the activation voltage of sodium channels is more sensitive to detect ciguatoxins than their effect on the peak sodium current amplitude.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-12
2022
2022-01-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/44380
url https://hdl.handle.net/10347/44380
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Axencia Galega de Innovación Not available ED431C 2021%2F01
IISCIII PI19 001248
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID 2020-11262RB-C21
EC Interreg Agritox EAPA-998-2018 EU
European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 778069-EMERTOX
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402839981228032
score 15,812455

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