Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis

11 páginas, 3 figuras

Detalles Bibliográficos
Autores: Diosdado Martín, Alicia, Gómez, Paula Josefina, Morchón, Rodrigo, Simón Martín, Fernando, González Miguel, Javier
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/345116
Acceso en línea:http://hdl.handle.net/10261/345116
https://api.elsevier.com/content/abstract/scopus_id/85030834774
Access Level:acceso abierto
Palabra clave:Dirofilaria immitis
Fibrinolytic system
Plasminogen
Wolbachia surface protein
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spelling Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosisDiosdado Martín, AliciaGómez, Paula JosefinaMorchón, RodrigoSimón Martín, FernandoGonzález Miguel, JavierDirofilaria immitisFibrinolytic systemPlasminogenWolbachia surface proteinDirofilaria immitis11 páginas, 3 figurasDirofilaria immitis is a mosquito-borne parasite that produces an inflammatory process in the wall of the blood vessels of its definitive host during cardiopulmonary dirofilariosis, known as proliferative endarteritis. Parasite antigens participate in the appearance of this inflammatory event, among other mechanisms through the over-activation of the host fibrinolytic system. Since Wolbachia, endosymbiont bacteria of filarial nematodes, is released into the vertebrate host when worms die, the aim of this work was to analyse the interaction between this bacteria and the host fibrinolytic system to complete the study of this part of the host-parasite relationships. For that purpose, the recombinant form of the major Wolbachia surface protein (rWSP) was cloned, sequenced and expressed and then, its ability to bind plasminogen and enhance the generation of plasmin was assessed. We demonstrated that rWSP is a conserved antigen within the family Onchocercidae with ability to bind plasminogen and stimulate plasmin generation in a tissue-plasminogen activator (t-PA) and lysine residues of the rWSP-dependent manner. These results indicate that the recruitment of plasminogen by Wolbachia and the possible excess of plasmin generated could contribute to exacerbate the pathological events occurred at the vascular level during cardiopulmonary dirofilariosis, as well as in other diseases caused by filarial nematodes that harbour Wolbachia, when the bacteria is released after the death of the worms.This research was supported by Agencia de Desarrollo Económico de Castilla y León (cofinanced with FEDER funds), Junta de Castilla y León, Spain.Peer reviewedElsevierJunta de Castilla y LeónGonzález Miguel, Javier [0000-0003-4279-4761]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/345116https://api.elsevier.com/content/abstract/scopus_id/85030834774reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésVeterinary parasitologyhttp://dx.doi.org/10.1016/j.vetpar.2017.10.001Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3451162026-05-22T06:33:51Z
dc.title.none.fl_str_mv Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
title Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
spellingShingle Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
Diosdado Martín, Alicia
Dirofilaria immitis
Fibrinolytic system
Plasminogen
Wolbachia surface protein
Dirofilaria immitis
title_short Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
title_full Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
title_fullStr Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
title_full_unstemmed Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
title_sort Interaction between Wolbachia and the fibrinolytic system as a possible pathological mechanism in cardiopulmonary dirofilariosis
dc.creator.none.fl_str_mv Diosdado Martín, Alicia
Gómez, Paula Josefina
Morchón, Rodrigo
Simón Martín, Fernando
González Miguel, Javier
author Diosdado Martín, Alicia
author_facet Diosdado Martín, Alicia
Gómez, Paula Josefina
Morchón, Rodrigo
Simón Martín, Fernando
González Miguel, Javier
author_role author
author2 Gómez, Paula Josefina
Morchón, Rodrigo
Simón Martín, Fernando
González Miguel, Javier
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Junta de Castilla y León
González Miguel, Javier [0000-0003-4279-4761]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Dirofilaria immitis
Fibrinolytic system
Plasminogen
Wolbachia surface protein
Dirofilaria immitis
topic Dirofilaria immitis
Fibrinolytic system
Plasminogen
Wolbachia surface protein
Dirofilaria immitis
description 11 páginas, 3 figuras
publishDate 2017
dc.date.none.fl_str_mv 2017
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/345116
https://api.elsevier.com/content/abstract/scopus_id/85030834774
url http://hdl.handle.net/10261/345116
https://api.elsevier.com/content/abstract/scopus_id/85030834774
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Veterinary parasitology
http://dx.doi.org/10.1016/j.vetpar.2017.10.001
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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