Preclinical safety study of a gemcitabine-controlled release polymer for locoregional administration in pancreatic cancer

There is a subpopulation of pancreatic tumor pluripotent cells with mechanisms of drug resistance that favor the locoregional recurrence and poor prognosis of the disease. In this work, the preclinical study of the safety of gemcitabine (GEM) impregnated in polymeric foams designed for intraoperativ...

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Detalhes bibliográficos
Autores: Rodríguez Martínez, Marta, Pérez Ortiz, José manuel, González , Lucia, Álvarez Lara, Irene, García Santos, Esther, Padilla Valverde, David, García González, María Teresa, Gómez Alonso, Sergio, Gracia Fernández, Ignacio, Rodríguez Romero, Juan Francisco, Redondo Calvo, Francisco Javier
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/35838
Acesso em linha:https://doi.org/10.1016/j.jddst.2023.104843
https://hdl.handle.net/10578/35838
Access Level:acceso abierto
Palavra-chave:Gemcitabine
Intraoperative administration
Pancreatic cancer
Supercritical CO2 foaming
Descrição
Resumo:There is a subpopulation of pancreatic tumor pluripotent cells with mechanisms of drug resistance that favor the locoregional recurrence and poor prognosis of the disease. In this work, the preclinical study of the safety of gemcitabine (GEM) impregnated in polymeric foams designed for intraoperative administration in pancreatic cancer (PC) is introduced.

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