Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process

The encapsulation of antioxidants with biocompatible polymers is essential for their protection against degradation factors like light and oxygen, and facilitates its solubility in the target medium. This work presents the co-precipitation of an ethanolic extract of rosemary leaves by supercritical...

ver descrição completa

Detalhes bibliográficos
Autores: Visentin, Alexis, Rodríguez Rojo, Soraya, Navarrete, Alexander, Maestri, Damián, Cocero Alonso, María José
Formato: artículo
Fecha de publicación:2012
País:España
Recursos:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/23432
Acesso em linha:http://uvadoc.uva.es/handle/10324/23432
Access Level:acceso abierto
Palavra-chave:Antioxidants
supercritical antisolvent (SAS)
Poloxamer
encapsulation
Rosemary
id ES_015e0bab1d11d1bb4e11b84f1bc0b619
oai_identifier_str oai:uvadoc.uva.es:10324/23432
network_acronym_str ES
network_name_str España
repository_id_str
spelling Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent processVisentin, AlexisRodríguez Rojo, SorayaNavarrete, AlexanderMaestri, DamiánCocero Alonso, María JoséAntioxidantssupercritical antisolvent (SAS)PoloxamerencapsulationRosemaryThe encapsulation of antioxidants with biocompatible polymers is essential for their protection against degradation factors like light and oxygen, and facilitates its solubility in the target medium. This work presents the co-precipitation of an ethanolic extract of rosemary leaves by supercritical antisolvent (SAS) process in poloxamers in order to improve the aqueous solubility of the extract. In a first step, the precipitation of antioxidants by SAS was studied in the range of temperatures from 25 to 50°C and pressures from 8 to 12 MPa. Total content of polyphenols was quantified according to the Folin-Cicalteu method. Also HPLC analyses were performed to verify the presence of some of the major rosemary antioxidants, carnosic and rosmarinic acid. The dissolution rate of rosemary polyphenols from particles was measured in isotonic phosphate buffer solution (pH = 6.8). The encapsulation of the extract was successfully achieved with a yield up to 100%. The total polyphenolic content was dissolved from the encapsulated product, in the aqueous medium, after one hour, whereas only 15% of the antioxidants of the pure precipitate were dissolved after 8 hours.The authors thank the financial support of Junta de Castilla y Leon (Spain) through the project GR11/2008. A. Visentin acknowledges the Erasmus Mundus program from the European Commission. S. Rodríguez-Rojo thanks the Spanish Ministry of Education for her postdoctoral grant.Elsevier2012info:eu-repo/semantics/articleapplication/pdfhttp://uvadoc.uva.es/handle/10324/23432reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidInglésinfo:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/234322026-06-13T12:44:47Z
dc.title.none.fl_str_mv Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
title Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
spellingShingle Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
Visentin, Alexis
Antioxidants
supercritical antisolvent (SAS)
Poloxamer
encapsulation
Rosemary
title_short Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
title_full Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
title_fullStr Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
title_full_unstemmed Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
title_sort Precipitation and encapsulation of rosemary antioxidants by supercritical antisolvent process
dc.creator.none.fl_str_mv Visentin, Alexis
Rodríguez Rojo, Soraya
Navarrete, Alexander
Maestri, Damián
Cocero Alonso, María José
author Visentin, Alexis
author_facet Visentin, Alexis
Rodríguez Rojo, Soraya
Navarrete, Alexander
Maestri, Damián
Cocero Alonso, María José
author_role author
author2 Rodríguez Rojo, Soraya
Navarrete, Alexander
Maestri, Damián
Cocero Alonso, María José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antioxidants
supercritical antisolvent (SAS)
Poloxamer
encapsulation
Rosemary
topic Antioxidants
supercritical antisolvent (SAS)
Poloxamer
encapsulation
Rosemary
description The encapsulation of antioxidants with biocompatible polymers is essential for their protection against degradation factors like light and oxygen, and facilitates its solubility in the target medium. This work presents the co-precipitation of an ethanolic extract of rosemary leaves by supercritical antisolvent (SAS) process in poloxamers in order to improve the aqueous solubility of the extract. In a first step, the precipitation of antioxidants by SAS was studied in the range of temperatures from 25 to 50°C and pressures from 8 to 12 MPa. Total content of polyphenols was quantified according to the Folin-Cicalteu method. Also HPLC analyses were performed to verify the presence of some of the major rosemary antioxidants, carnosic and rosmarinic acid. The dissolution rate of rosemary polyphenols from particles was measured in isotonic phosphate buffer solution (pH = 6.8). The encapsulation of the extract was successfully achieved with a yield up to 100%. The total polyphenolic content was dissolved from the encapsulated product, in the aqueous medium, after one hour, whereas only 15% of the antioxidants of the pure precipitate were dissolved after 8 hours.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://uvadoc.uva.es/handle/10324/23432
url http://uvadoc.uva.es/handle/10324/23432
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402578365710336
score 15,228081

Registos relacionados