Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

11 pages, 6 figures.- PMID: 20832341 [PubMed]PMCID: PMC2946444 [Available on 2011/9/1]

Detalhes bibliográficos
Autores: Pérez de Diego, Rebeca, Sancho-Shimizu, Vanessa, Lorenzo, Lazaro, Puel, Anne, Plancoulaine, Sabine, Picard, Capucine, Herman, Melina, Cardon, Annabelle, Durandy, Anne, Bustamante, Jacinta, Vallabhapurapu, Sivakumar, Bravo, Jerónimo, Warnatz, Klaus, Chaix, Yves, Cascarrigny, Françoise, Lebon, Pierre, Rozenberg, Flore, Karin, Michael, Tardieu, Marc, Al-Muhsen, Saleh, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Abel, Laurent, Casanova, Jean-Laurent
Formato: artículo
Fecha de publicación:2010
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/32922
Acesso em linha:http://hdl.handle.net/10261/32922
Access Level:acceso abierto
Palavra-chave:Herpes simplex encephalitis (HSE)
TRAF3
Herpes simplex virus 1 (HSV-1)
TLR3
Interferon (IFN)
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spelling Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitisPérez de Diego, RebecaSancho-Shimizu, VanessaLorenzo, LazaroPuel, AnnePlancoulaine, SabinePicard, CapucineHerman, MelinaCardon, AnnabelleDurandy, AnneBustamante, JacintaVallabhapurapu, SivakumarBravo, JerónimoWarnatz, KlausChaix, YvesCascarrigny, FrançoiseLebon, PierreRozenberg, FloreKarin, MichaelTardieu, MarcAl-Muhsen, SalehJouanguy, EmmanuelleZhang, Shen-YingAbel, LaurentCasanova, Jean-LaurentHerpes simplex encephalitis (HSE)TRAF3Herpes simplex virus 1 (HSV-1)TLR3Interferon (IFN)11 pages, 6 figures.- PMID: 20832341 [PubMed]PMCID: PMC2946444 [Available on 2011/9/1]Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-alpha (IFN-alpha), IFN-beta, and IFN-lambda production, including Toll-like receptor 3 (TLR3), which is deficient in some patients with herpes simplex virus-1 encephalitis (HSE). Mice lacking TRAF3 die in the neonatal period, preventing direct investigation of the role of TRAF3 in immune responses and host defenses in vivo. Here, we report autosomal dominant, human TRAF3 deficiency in a young adult with a history of HSE in childhood. The TRAF3 mutant allele is loss-of-expression, loss-of-function, dominant-negative and associated with impaired, but not abolished, TRAF3-dependent responses upon stimulation of both TNF receptors and receptors that induce IFN production. TRAF3 deficiency is associated with a clinical phenotype limited to HSE resulting from the impairment of TLR3-dependent induction of IFN. Thus, TLR3-mediated immunity against primary infection by HSV-1 in the central nervous system is critically dependent on TRAF3This study was supported by the AXA Research fund, the Schlumberger Foundation, the BNP-Paribas Foundation, the Groupement d’Intérêt Scientifique Maladies Rares, the Action Concertée Incitative de Microbiologie, the March of Dimes, the Agence Nationale pour la Recherche, the Eppley Foundation, the National Institute of Allergy and Infectious Diseases grant number 1R01AI088364, the Thrasher Research Fund, the Jeffrey Modell Foundation and Talecris Biotherapeutics, the St. Giles Foundation, the Rockefeller University Center for Clinical and Translational Science grant number 5UL1RR024143, and the Rockefeller University. P.R. is supported by a European Union FP6 grant. J.-L.C. was an international scholar of the Howard Hughes Medical Institute until 2008.Peer reviewedElsevier201120112010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/32922reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.immuni.2010.08.014info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/329222026-05-22T06:33:51Z
dc.title.none.fl_str_mv Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
title Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
spellingShingle Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
Pérez de Diego, Rebeca
Herpes simplex encephalitis (HSE)
TRAF3
Herpes simplex virus 1 (HSV-1)
TLR3
Interferon (IFN)
title_short Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
title_full Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
title_fullStr Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
title_full_unstemmed Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
title_sort Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis
dc.creator.none.fl_str_mv Pérez de Diego, Rebeca
Sancho-Shimizu, Vanessa
Lorenzo, Lazaro
Puel, Anne
Plancoulaine, Sabine
Picard, Capucine
Herman, Melina
Cardon, Annabelle
Durandy, Anne
Bustamante, Jacinta
Vallabhapurapu, Sivakumar
Bravo, Jerónimo
Warnatz, Klaus
Chaix, Yves
Cascarrigny, Françoise
Lebon, Pierre
Rozenberg, Flore
Karin, Michael
Tardieu, Marc
Al-Muhsen, Saleh
Jouanguy, Emmanuelle
Zhang, Shen-Ying
Abel, Laurent
Casanova, Jean-Laurent
author Pérez de Diego, Rebeca
author_facet Pérez de Diego, Rebeca
Sancho-Shimizu, Vanessa
Lorenzo, Lazaro
Puel, Anne
Plancoulaine, Sabine
Picard, Capucine
Herman, Melina
Cardon, Annabelle
Durandy, Anne
Bustamante, Jacinta
Vallabhapurapu, Sivakumar
Bravo, Jerónimo
Warnatz, Klaus
Chaix, Yves
Cascarrigny, Françoise
Lebon, Pierre
Rozenberg, Flore
Karin, Michael
Tardieu, Marc
Al-Muhsen, Saleh
Jouanguy, Emmanuelle
Zhang, Shen-Ying
Abel, Laurent
Casanova, Jean-Laurent
author_role author
author2 Sancho-Shimizu, Vanessa
Lorenzo, Lazaro
Puel, Anne
Plancoulaine, Sabine
Picard, Capucine
Herman, Melina
Cardon, Annabelle
Durandy, Anne
Bustamante, Jacinta
Vallabhapurapu, Sivakumar
Bravo, Jerónimo
Warnatz, Klaus
Chaix, Yves
Cascarrigny, Françoise
Lebon, Pierre
Rozenberg, Flore
Karin, Michael
Tardieu, Marc
Al-Muhsen, Saleh
Jouanguy, Emmanuelle
Zhang, Shen-Ying
Abel, Laurent
Casanova, Jean-Laurent
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Herpes simplex encephalitis (HSE)
TRAF3
Herpes simplex virus 1 (HSV-1)
TLR3
Interferon (IFN)
topic Herpes simplex encephalitis (HSE)
TRAF3
Herpes simplex virus 1 (HSV-1)
TLR3
Interferon (IFN)
description 11 pages, 6 figures.- PMID: 20832341 [PubMed]PMCID: PMC2946444 [Available on 2011/9/1]
publishDate 2010
dc.date.none.fl_str_mv 2010
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/32922
url http://hdl.handle.net/10261/32922
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.immuni.2010.08.014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869402502000017408
score 15.812455

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