Neurocysticercosis: Neurology and neurobiology

Neurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only defi...

Full description

Bibliographic Details
Author: Carpio Rodas, Luis Arturo
Format: article
Status:Published version
Publication Date:2014
Country:Ecuador
Institution:Universidad de Cuenca
Repository:Repositorio Universidad de Cuenca
OAI Identifier:oai:dspace.ucuenca.edu.ec:123456789/29094
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
Access Level:Open access
Keyword:Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
id EC_ca552d84cdffdd2989a16e3f95b1e5fa
oai_identifier_str oai:dspace.ucuenca.edu.ec:123456789/29094
network_acronym_str EC
network_name_str Ecuador
repository_id_str
spelling 2018-01-11T16:47:23Z2018-01-11T16:47:23Z2014-01-019781461481003; 9781461480990https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84http://dspace.ucuenca.edu.ec/handle/123456789/2909410.1007/978-1-4614-8100-3_7Neurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only definitive host of T. solium, while pigs are the intermediate hosts. Humans may become intermediate host by ingesting food or water contaminated by T. solium eggs.Infection is associated with local and systemic immune-inflammatory responses modulated by the developmental stage of the parasite in the host (vesicular, colloidal. granular-nodular, and calcified stages) and by the central nervous system compartment where the parasites are located. Genetic diversity of cysticerci has been studied and the genome of T. solium is currently being sequenced.The clinical manifestations are heterogeneous and depend mainly on the localization of cysts and immune response to the host. Seizures, headache, focal deficits and cognitive abnormalities are the most frequent manifestations. The prognosis is good; nevertheless, it may lead to long-term neurological sequels such as epilepsy and hydrocephalus.Diagnosis is made mainly by neuroimaging, which is useful in the detection of evolutionary stage, number and localization of cysts. Immunological testing can be helpful; nonetheless, a negative test does not rule out the diagnosis. Treatment is complex and should be individualized, based on location and viability of the parasites. In most cases treatment is only symptomatic. Antihelminthic drugs are effective in approximately one-third of patients with parenchymal viable cysts. The most effective approach to Taeniasis/cysticercosis is prevention. This should be a primary public health focus for poor countries.en_USSPRINGER NEW YORKNeglected Tropical Diseases and Conditions of the Nervous Systemreponame:Repositorio Universidad de Cuencainstname:Universidad de Cuencainstacron:UCUENCAAlbendazoleEpilepsyImagingParasitic InfectionPraziquantelSeizuresTaenia SoliumTaeniasis/CysticercosisNeurocysticercosis: Neurology and neurobiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article01007379562022-01-01 0:00carpio, a., school of medicine, university of cuenca, cuenca, ecuador, g.h. sergievsky center, columbia university, new york, ny, united states, f. proano y d. cordova (esquina), 4to piso, cuenca, ecuadorCarpio, A.; School of Medicine, University of CuencaEcuador; email: arturocarpio@etapanet.netSCOPUS3info:eu-repo/semantics/openAccessCarpio Rodas, Luis ArturoTHUMBNAILdocumento.pdf.jpgdocumento.pdf.jpgGenerated Thumbnailimage/jpeg1034https://dspace-test.ucuenca.edu.ec/bitstreams/a65c08de-a4b7-469b-ab62-19b5c43d8dea/download7a31ccbb52fd9daf39739c5adcf8a953MD54ORIGINALdocumento.pdfapplication/pdf172975https://dspace-test.ucuenca.edu.ec/bitstreams/36d3074d-e598-4623-82dc-722eefb48299/downloadf1349357eb9745d0313ac62cac94354eMD51LICENSElicense.txttext/plain20414https://dspace-test.ucuenca.edu.ec/bitstreams/34f72693-eac5-40b5-9e05-7b6ebb634f0f/download8f9b75d7c157ae756c96db514efbf794MD52TEXTdocumento.pdf.txtdocumento.pdf.txtExtracted texttext/plain147https://dspace-test.ucuenca.edu.ec/bitstreams/b8cba9b9-dc86-44ec-b220-6db301b42549/download9ec9c491df26553b2672048b0cf6dca8MD53123456789/290942020-07-31 20:14:56.163open.accessoai:dspace.ucuenca.edu.ec:123456789/29094https://dspace-test.ucuenca.edu.ecInstitucionalhttp://dspace.ucuenca.edu.ec/Universidad públicahttps://www.ucuenca.edu.ec/http://dspace.ucuenca.edu.ec/oai.Ecuador...opendoar:41862020-08-01T01:14:56Repositorio Universidad de Cuenca - Universidad de Cuencafalse
dc.title.none.fl_str_mv Neurocysticercosis: Neurology and neurobiology
title Neurocysticercosis: Neurology and neurobiology
spellingShingle Neurocysticercosis: Neurology and neurobiology
Carpio Rodas, Luis Arturo
Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
title_short Neurocysticercosis: Neurology and neurobiology
title_full Neurocysticercosis: Neurology and neurobiology
title_fullStr Neurocysticercosis: Neurology and neurobiology
title_full_unstemmed Neurocysticercosis: Neurology and neurobiology
title_sort Neurocysticercosis: Neurology and neurobiology
dc.creator.none.fl_str_mv Carpio Rodas, Luis Arturo
author Carpio Rodas, Luis Arturo
author_facet Carpio Rodas, Luis Arturo
author_role author
dc.subject.none.fl_str_mv Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
topic Albendazole
Epilepsy
Imaging
Parasitic Infection
Praziquantel
Seizures
Taenia Solium
Taeniasis/Cysticercosis
description Neurocysticercosis, the most common parasitic brain disease worldwide, is due to the larvae infestation of Taenia solium. It is an endemic, neglected disease in poor countries with deprived sanitation, and is increasingly being reported in wealthy countries due to migration. Humans are the only definitive host of T. solium, while pigs are the intermediate hosts. Humans may become intermediate host by ingesting food or water contaminated by T. solium eggs.Infection is associated with local and systemic immune-inflammatory responses modulated by the developmental stage of the parasite in the host (vesicular, colloidal. granular-nodular, and calcified stages) and by the central nervous system compartment where the parasites are located. Genetic diversity of cysticerci has been studied and the genome of T. solium is currently being sequenced.The clinical manifestations are heterogeneous and depend mainly on the localization of cysts and immune response to the host. Seizures, headache, focal deficits and cognitive abnormalities are the most frequent manifestations. The prognosis is good; nevertheless, it may lead to long-term neurological sequels such as epilepsy and hydrocephalus.Diagnosis is made mainly by neuroimaging, which is useful in the detection of evolutionary stage, number and localization of cysts. Immunological testing can be helpful; nonetheless, a negative test does not rule out the diagnosis. Treatment is complex and should be individualized, based on location and viability of the parasites. In most cases treatment is only symptomatic. Antihelminthic drugs are effective in approximately one-third of patients with parenchymal viable cysts. The most effective approach to Taeniasis/cysticercosis is prevention. This should be a primary public health focus for poor countries.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014-01-01
dc.date.accessioned.none.fl_str_mv 2018-01-11T16:47:23Z
dc.date.available.none.fl_str_mv 2018-01-11T16:47:23Z
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.isbn.none.fl_str_mv 9781461481003; 9781461480990
dc.identifier.uri.none.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
dc.identifier.doi.none.fl_str_mv 10.1007/978-1-4614-8100-3_7
identifier_str_mv 9781461481003; 9781461480990
10.1007/978-1-4614-8100-3_7
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84948146980&doi=10.1007%2f978-1-4614-8100-3_7&partnerID=40&md5=c3ff7b03a81f73630119723854e5eb84
http://dspace.ucuenca.edu.ec/handle/123456789/29094
dc.language.iso.none.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER NEW YORK
publisher.none.fl_str_mv SPRINGER NEW YORK
dc.source.none.fl_str_mv Neglected Tropical Diseases and Conditions of the Nervous System
reponame:Repositorio Universidad de Cuenca
instname:Universidad de Cuenca
instacron:UCUENCA
instname_str Universidad de Cuenca
instacron_str UCUENCA
institution UCUENCA
reponame_str Repositorio Universidad de Cuenca
collection Repositorio Universidad de Cuenca
bitstream.url.fl_str_mv https://dspace-test.ucuenca.edu.ec/bitstreams/a65c08de-a4b7-469b-ab62-19b5c43d8dea/download
https://dspace-test.ucuenca.edu.ec/bitstreams/36d3074d-e598-4623-82dc-722eefb48299/download
https://dspace-test.ucuenca.edu.ec/bitstreams/34f72693-eac5-40b5-9e05-7b6ebb634f0f/download
https://dspace-test.ucuenca.edu.ec/bitstreams/b8cba9b9-dc86-44ec-b220-6db301b42549/download
bitstream.checksum.fl_str_mv 7a31ccbb52fd9daf39739c5adcf8a953
f1349357eb9745d0313ac62cac94354e
8f9b75d7c157ae756c96db514efbf794
9ec9c491df26553b2672048b0cf6dca8
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Universidad de Cuenca - Universidad de Cuenca
repository.mail.fl_str_mv .
_version_ 1873869785533513728
score 14,717255

Similar Items