Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural bas...

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Detalles Bibliográficos
Autores: Murakami, Mário T., Melo, Cristiane C., Angulo Ugalde, Yamileth, Lomonte, Bruno, Arni, Raghuvir K.
Tipo de recurso: artículo
Fecha de publicación:2006
País:Costa Rica
Institución:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/74162
Acceso en línea:http://scripts.iucr.org/cgi-bin/paper?S1744309106010700
https://hdl.handle.net/10669/74162
Access Level:acceso abierto
Palabra clave:myotoxin
Snake venom
Lys49 phospholipase A2
anion-binding sites
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dc.title.es_ES.fl_str_mv Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
title Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
spellingShingle Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
Murakami, Mário T.
myotoxin
Snake venom
Lys49 phospholipase A2
anion-binding sites
title_short Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
title_full Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
title_fullStr Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
title_full_unstemmed Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
title_sort Structure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom
dc.creator.none.fl_str_mv Murakami, Mário T.
Melo, Cristiane C.
Angulo Ugalde, Yamileth
Lomonte, Bruno
Arni, Raghuvir K.
author Murakami, Mário T.
author_facet Murakami, Mário T.
Melo, Cristiane C.
Angulo Ugalde, Yamileth
Lomonte, Bruno
Arni, Raghuvir K.
author_role author
author2 Melo, Cristiane C.
Angulo Ugalde, Yamileth
Lomonte, Bruno
Arni, Raghuvir K.
author2_role author
author
author
author
dc.subject.es_ES.fl_str_mv myotoxin
Snake venom
Lys49 phospholipase A2
anion-binding sites
topic myotoxin
Snake venom
Lys49 phospholipase A2
anion-binding sites
description Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 A ° resolution and the anion-binding site has been characterized.
publishDate 2006
dc.date.issued.none.fl_str_mv 2006
dc.date.accessioned.none.fl_str_mv 2018-02-26T21:26:31Z
dc.date.available.none.fl_str_mv 2018-02-26T21:26:31Z
dc.type.none.fl_str_mv artículo original
http://purl.org/coar/resource_type/c_2df8fbb1
info:eu-repo/semantics/article
format article
dc.identifier.citation.none.fl_str_mv http://scripts.iucr.org/cgi-bin/paper?S1744309106010700
dc.identifier.issn.none.fl_str_mv 1744-3091
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10669/74162
dc.identifier.doi.none.fl_str_mv 10.1107/S1744309106010700
url http://scripts.iucr.org/cgi-bin/paper?S1744309106010700
https://hdl.handle.net/10669/74162
identifier_str_mv 1744-3091
10.1107/S1744309106010700
dc.language.iso.es_ES.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv acceso abierto
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
rights_invalid_str_mv acceso abierto
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.es_ES.fl_str_mv Acta Crystallographica F 62, 423-426 (2006)
dc.source.none.fl_str_mv reponame:Kérwá
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Kérwá
collection Kérwá
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spelling Murakami, Mário T.8f8007f3-5e0b-44fa-bb73-e689982c105f600Melo, Cristiane C.d1a2d8aa-b1fa-4b2d-9307-52a4d47905b4Angulo Ugalde, Yamileth76ca7ee8-9d85-4e33-9dc1-357e266c9471600Lomonte, Bruno581484ad-aaa8-46b1-bc0e-f380d895640c600Arni, Raghuvir K.ee6da8e5-11e8-4716-b8e1-faab01daadb66002018-02-26T21:26:31Z2018-02-26T21:26:31Z2006http://scripts.iucr.org/cgi-bin/paper?S17443091060107001744-3091https://hdl.handle.net/10669/7416210.1107/S1744309106010700Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 A ° resolution and the anion-binding site has been characterized.Consejo Nacional de Ciencia y Tecnología/[FV-058-02]/CONICIT/Costa RicaFundação de Amparo à Pesquisa do Estado de São Paulo/[]/FAPESP/BrasilConselho Nacional de Desenvolvimento Científico e Tecnológico/[]/CNPq/BrasilUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP)UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de Medicinaen_USacceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessActa Crystallographica F 62, 423-426 (2006)reponame:Kérwáinstname:Universidad de Costa Ricainstacron:UCRmyotoxinSnake venomLys49 phospholipase A2anion-binding sitesStructure of myotoxin-II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venomartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleORIGINAL2006_PLA2_ActaCrystF_Murakami_structure_nummifer_II.pdf2006_PLA2_ActaCrystF_Murakami_structure_nummifer_II.pdfapplication/pdf612692https://www.kerwa.ucr.ac.cr/bitstreams/2e786dac-6b7e-4ae8-b178-ac135ecacdf7/download94c589fb3f1873985a084ab03b177795MD51LICENSElicense.txtlicense.txttext/plain; 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