Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico

The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrh...

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Autores: Segura, Álvaro, Herrera, María, Vargas, Mariángela, Villalta, Mauren, Uscanga-Reynell, Alfredo, León, Guillermo, Gutiérrez, José María
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:Costa Rica
Recursos:Universidad de Costa Rica
Repositório:Portal de Revistas UCR
Idioma:inglês
OAI Identifier:oai:portal.ucr.ac.cr:article/18908
Acesso em linha:https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908
Access Level:Acceso aberto
Palavra-chave:snake venom
antivenom
Bothrops
Crotalus
neutralization
veneno de serpiente
antiveneno
neutralización
id CR_2cb80ed6c852f398dc8e9169d2e9bac0
oai_identifier_str oai:portal.ucr.ac.cr:article/18908
network_acronym_str CR
network_name_str Costa Rica
repository_id_str
dc.title.none.fl_str_mv Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
Eficacia de un antiveneno poliespecífico producido en México para neutralizar, a nivel preclínico, las actividades tóxicas de venenos de Bothrops sp (Serpentes: Viperidae) de importancia médica
title Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
spellingShingle Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
Segura, Álvaro
snake venom
antivenom
Bothrops
Crotalus
neutralization
veneno de serpiente
antiveneno
Bothrops
Crotalus
neutralización
title_short Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
title_full Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
title_fullStr Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
title_full_unstemmed Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
title_sort Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico
dc.creator.none.fl_str_mv Segura, Álvaro
Herrera, María
Vargas, Mariángela
Villalta, Mauren
Uscanga-Reynell, Alfredo
León, Guillermo
Gutiérrez, José María
author Segura, Álvaro
author_facet Segura, Álvaro
Herrera, María
Vargas, Mariángela
Villalta, Mauren
Uscanga-Reynell, Alfredo
León, Guillermo
Gutiérrez, José María
author_role author
author2 Herrera, María
Vargas, Mariángela
Villalta, Mauren
Uscanga-Reynell, Alfredo
León, Guillermo
Gutiérrez, José María
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv snake venom
antivenom
Bothrops
Crotalus
neutralization
veneno de serpiente
antiveneno
Bothrops
Crotalus
neutralización
topic snake venom
antivenom
Bothrops
Crotalus
neutralization
veneno de serpiente
antiveneno
Bothrops
Crotalus
neutralización
description The assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenating and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica). Standard laboratory tests to determine these activities were used. In agreement with previous studies with bothropic antivenoms in Latin America, a pattern of cross-neutralization of heterologous venoms was observed. However, the antivenom had low neutralizing potency against defibrinogenating effect of the venoms of B. atrox (Colombia) and B. asper (Costa Rica), and failed to neutralize the in vitro coagulant activity of the venom of B. asper (Costa Rica) at the highest antivenom/venom ratio tested. It is concluded that, with the exception of coagulant and defibrinogenating activities of B. asper (Costa Rica) venom, this antivenom neutralizes toxic effects of various Bothrops sp venoms. Future studies are necessary to assess the efficacy of this antivenom against other viperid venoms.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
Article
artículo original
http://purl.org/coar/resource_type/c_2df8fbb1
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908
10.15517/rbt.v65i1.18908
url https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908
identifier_str_mv 10.15517/rbt.v65i1.18908
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908/28211
https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908/28212
dc.rights.none.fl_str_mv Derechos de autor 2017 Revista de Biología Tropical
http://creativecommons.org/licenses/by/4.0
acceso abierto
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2017 Revista de Biología Tropical
http://creativecommons.org/licenses/by/4.0
acceso abierto
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad de Costa Rica
publisher.none.fl_str_mv Universidad de Costa Rica
dc.source.none.fl_str_mv Revista de Biología Tropical; Vol. 65 No. 1 (2017): Volume 65 – Regular number 1 – March 2017; 345–350
Revista de Biología Tropical; Vol. 65 Núm. 1 (2017): Volumen 65 – Número regular 1 – Marzo 2017; 345–350
Revista Biología Tropical; Vol. 65 N.º 1 (2017): Volumen 65 – Número regular 1 – Marzo 2017; 345–350
2215-2075
0034-7744
10.15517/rbt.v65i1
reponame:Portal de Revistas UCR
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Portal de Revistas UCR
collection Portal de Revistas UCR
repository.name.fl_str_mv Portal de Revistas UCR - Universidad de Costa Rica
repository.mail.fl_str_mv jorge.polanco@ucr.ac.cr
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spelling Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in MexicoEficacia de un antiveneno poliespecífico producido en México para neutralizar, a nivel preclínico, las actividades tóxicas de venenos de Bothrops sp (Serpentes: Viperidae) de importancia médicaSegura, ÁlvaroHerrera, MaríaVargas, MariángelaVillalta, MaurenUscanga-Reynell, AlfredoLeón, GuillermoGutiérrez, José Maríasnake venomantivenomBothropsCrotalusneutralizationveneno de serpienteantivenenoBothropsCrotalusneutralizaciónThe assessment of the preclinical neutralizing ability of antivenoms in Latin America is necessary to determine their scope of efficacy. This study was aimed at analyzing the neutralizing efficacy of a polyspecific bothropic-crotalic antivenom manufactured by BIRMEX in Mexico against lethal, hemorrhagic, defibrinogenating and in vitro coagulant activities of the venoms of Bothrops jararaca (Brazil), B. atrox (Perú and Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia), and B. asper (Costa Rica). Standard laboratory tests to determine these activities were used. In agreement with previous studies with bothropic antivenoms in Latin America, a pattern of cross-neutralization of heterologous venoms was observed. However, the antivenom had low neutralizing potency against defibrinogenating effect of the venoms of B. atrox (Colombia) and B. asper (Costa Rica), and failed to neutralize the in vitro coagulant activity of the venom of B. asper (Costa Rica) at the highest antivenom/venom ratio tested. It is concluded that, with the exception of coagulant and defibrinogenating activities of B. asper (Costa Rica) venom, this antivenom neutralizes toxic effects of various Bothrops sp venoms. Future studies are necessary to assess the efficacy of this antivenom against other viperid venoms.Es necesario estudiar a nivel preclínico la capacidad neutralizante de los antivenenos producidos en América Latina, para conocer su espectro de cobertura. En este estudio se analizó la eficacia preclínica de un antiveneno poliespecífico botrópico-crotálico producido por BIRMEX, en México, para neutralizar los efectos letal, hemorrágico, desfibrinogenante y coagulante in vitro de los venenos de Bothrops jararaca (Brasil), B. atrox (Perú y Colombia), B. diporus (Argentina), B. mattogrossensis (Bolivia) y B. asper (Costa Rica). Se emplearon metodologías de laboratorio estándar en los análisis. En consonancia con estudios anteriores con diversos antivenenos botrópicos en América Latina, se observó un amplio patrón de neutralización de estos venenos heterólogos en la mayoría de los efectos estudiados. Sin embargo, el antiveneno mostró una baja capacidad neutralizante contra el efecto desfibrinogenante de los venenos de B. atrox (Colombia) y B. asper (Costa Rica) y no neutralizó la actividad coagulante in vitro del veneno de B. asper (Costa Rica) a la máxima razón antiveneno/veneno empleada.Universidad de Costa Rica2017-03-01info:eu-repo/semantics/publishedVersionArticleartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdftext/htmlhttps://revistas.ucr.ac.cr/index.php/rbt/article/view/1890810.15517/rbt.v65i1.18908Revista de Biología Tropical; Vol. 65 No. 1 (2017): Volume 65 – Regular number 1 – March 2017; 345–350Revista de Biología Tropical; Vol. 65 Núm. 1 (2017): Volumen 65 – Número regular 1 – Marzo 2017; 345–350Revista Biología Tropical; Vol. 65 N.º 1 (2017): Volumen 65 – Número regular 1 – Marzo 2017; 345–3502215-20750034-774410.15517/rbt.v65i1reponame:Portal de Revistas UCRinstname:Universidad de Costa Ricainstacron:UCRenghttps://revistas.ucr.ac.cr/index.php/rbt/article/view/18908/28211https://revistas.ucr.ac.cr/index.php/rbt/article/view/18908/28212Derechos de autor 2017 Revista de Biología Tropicalhttp://creativecommons.org/licenses/by/4.0acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccess2022-06-09T18:02:38Zoai:portal.ucr.ac.cr:article/18908Portal de revistashttps://revistas.ucr.ac.cr/Universidadhttp://www.ucr.ac.crhttps://revistas.ucr.ac.cr/index.php/index/oaijorge.polanco@ucr.ac.crCosta RicaNo aplicaNo aplicaNo aplicaopendoar:2025-08-13T10:18:13.165Portal de Revistas UCR - Universidad de Costa Ricafalse
score 15,228081

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