Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects

A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well with cardiac glycosides (inhibitors of animal NaC/KC-ATPases) from its milkweed...

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Detalhes bibliográficos
Autores: Petschenka, Georg, Fei, Colleen S., Araya Barrantes, Juan José, Schröder, Susanne, Timmermann, Barbara N., Agrawal, Anurag A.
Formato: artículo
Fecha de publicación:2018
País:Costa Rica
Recursos:Universidad de Costa Rica
Repositorio:Kérwá
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/80930
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fpls.2018.01424/full
https://hdl.handle.net/10669/80930
Access Level:acceso abierto
Palavra-chave:Na+/K+ -ATPase
Monarch butterfly
Cardenolide
Cardiac glycoside
Phytochemical diversity
Structure–activity relationship
Toxin–receptor interaction
Resistance
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repository_id_str
dc.title.es_ES.fl_str_mv Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
title Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
spellingShingle Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
Petschenka, Georg
Na+/K+ -ATPase
Monarch butterfly
Cardenolide
Cardiac glycoside
Phytochemical diversity
Structure–activity relationship
Toxin–receptor interaction
Resistance
title_short Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
title_full Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
title_fullStr Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
title_full_unstemmed Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
title_sort Relative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insects
dc.creator.none.fl_str_mv Petschenka, Georg
Fei, Colleen S.
Araya Barrantes, Juan José
Schröder, Susanne
Timmermann, Barbara N.
Agrawal, Anurag A.
author Petschenka, Georg
author_facet Petschenka, Georg
Fei, Colleen S.
Araya Barrantes, Juan José
Schröder, Susanne
Timmermann, Barbara N.
Agrawal, Anurag A.
author_role author
author2 Fei, Colleen S.
Araya Barrantes, Juan José
Schröder, Susanne
Timmermann, Barbara N.
Agrawal, Anurag A.
author2_role author
author
author
author
author
dc.subject.es_ES.fl_str_mv Na+/K+ -ATPase
Monarch butterfly
Cardenolide
Cardiac glycoside
Phytochemical diversity
Structure–activity relationship
Toxin–receptor interaction
Resistance
topic Na+/K+ -ATPase
Monarch butterfly
Cardenolide
Cardiac glycoside
Phytochemical diversity
Structure–activity relationship
Toxin–receptor interaction
Resistance
description A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well with cardiac glycosides (inhibitors of animal NaC/KC-ATPases) from its milkweed host plants, but selective inhibition of its NaC/KC-ATPase by different compounds has not been previously tested. We applied 17 cardiac glycosides to the D. plexippus-NaC/KC-ATPase and to the more susceptible NaC/KC-ATPases of two non-adapted insects (Euploea core and Schistocerca gregaria). Structural features (e.g., sugar residues) predicted in vitro inhibitory activity and comparison of insect NaC/KC-ATPases revealed that the monarch has evolved a highly resistant enzyme overall. Nonetheless, we found evidence for relative selectivity of individual cardiac glycosides reaching from 4- to 94-fold differences of inhibition between non-adapted NaC/KC-ATPase and D. plexippus-NaC/KC-ATPase. This toxin receptor specificity suggests a mechanism how plants could target herbivores selectively and thus provides a strong basis for pairwise coevolutionary interactions between plants and herbivorous insects.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2020-04-27T20:03:07Z
dc.date.available.none.fl_str_mv 2020-04-27T20:03:07Z
dc.type.none.fl_str_mv artículo original
http://purl.org/coar/resource_type/c_2df8fbb1
info:eu-repo/semantics/article
format article
dc.identifier.citation.none.fl_str_mv https://www.frontiersin.org/articles/10.3389/fpls.2018.01424/full
dc.identifier.issn.none.fl_str_mv 1664-462X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10669/80930
dc.identifier.doi.none.fl_str_mv 10.3389/fpls.2018.01424
url https://www.frontiersin.org/articles/10.3389/fpls.2018.01424/full
https://hdl.handle.net/10669/80930
identifier_str_mv 1664-462X
10.3389/fpls.2018.01424
dc.language.iso.es_ES.fl_str_mv en_US
language_invalid_str_mv en_US
dc.rights.none.fl_str_mv acceso abierto
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
rights_invalid_str_mv acceso abierto
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eu_rights_str_mv openAccess
dc.source.es_ES.fl_str_mv Revista Frontiers in Plant Science, vol.9(1424), pp.1-13
dc.source.none.fl_str_mv reponame:Kérwá
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Kérwá
collection Kérwá
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spelling Petschenka, Georg0fc07880-0ebc-4ee2-9f61-9818772fbdbbFei, Colleen S.959aaf4f-580c-4903-a910-e65299aedce1Araya Barrantes, Juan José0ad1ff6a-35bc-4975-9c95-d04a4c73d0d6600Schröder, Susanne6754adc4-40ec-4bd2-a2fe-4a7e7e15f71eTimmermann, Barbara N.ed5e7926-d642-4f6b-bb17-e8a45a763236Agrawal, Anurag A.8cb395bc-b955-48e9-aec9-e81726a544482020-04-27T20:03:07Z2020-04-27T20:03:07Z2018https://www.frontiersin.org/articles/10.3389/fpls.2018.01424/full1664-462Xhttps://hdl.handle.net/10669/8093010.3389/fpls.2018.01424A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well with cardiac glycosides (inhibitors of animal NaC/KC-ATPases) from its milkweed host plants, but selective inhibition of its NaC/KC-ATPase by different compounds has not been previously tested. We applied 17 cardiac glycosides to the D. plexippus-NaC/KC-ATPase and to the more susceptible NaC/KC-ATPases of two non-adapted insects (Euploea core and Schistocerca gregaria). Structural features (e.g., sugar residues) predicted in vitro inhibitory activity and comparison of insect NaC/KC-ATPases revealed that the monarch has evolved a highly resistant enzyme overall. Nonetheless, we found evidence for relative selectivity of individual cardiac glycosides reaching from 4- to 94-fold differences of inhibition between non-adapted NaC/KC-ATPase and D. plexippus-NaC/KC-ATPase. This toxin receptor specificity suggests a mechanism how plants could target herbivores selectively and thus provides a strong basis for pairwise coevolutionary interactions between plants and herbivorous insects.German Research Foundation/[GP, PE 2059/1-1]/DFG/AlemaniaUS National Science Foundation/[AA,DEB-1619885]/NSF/Estados UnidosUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)en_USacceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessRevista Frontiers in Plant Science, vol.9(1424), pp.1-13reponame:Kérwáinstname:Universidad de Costa Ricainstacron:UCRNa+/K+ -ATPaseMonarch butterflyCardenolideCardiac glycosidePhytochemical diversityStructure–activity relationshipToxin–receptor interactionResistanceRelative Selectivity of Plant Cardenolides for Na+/K+ -ATPases From the Monarch Butterfly and Non-resistant Insectsartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleORIGINALPetschenkaetal2018_relativeselectivitycardenolides_(1).pdfPetschenkaetal2018_relativeselectivitycardenolides_(1).pdfDocumento completoapplication/pdf7531194https://www.kerwa.ucr.ac.cr/bitstreams/ed1bb4ba-bcfa-4a3d-980c-6d711a2191fe/download91ceea4a19c95880f9bc77e89d193830MD51LICENSElicense.txtlicense.txttext/plain; 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