Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K

COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous,...

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Autores: Laiton Donato, Katherine, Usme Ciro, José Aldemar, Franco Muñoz, Carlos, Álvarez Díaz, Diego Alejandro, Ruiz Moreno, Hector A., Reales Gonzalez, Jhonnatan, Prada, Diego A., Corchuelo, Sheryll, Herrera Sepulveda, Maria T., Naizaque, Julián Ricardo, Santamaría, Gerardo, Wiesner, Magdalena, Walteros, Diana Marcela, Ospina Martínez, Martha L., Mercado Reyes, Marcela
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Colombia
Recursos:Universidad Cooperativa de Colombia
Repositorio:Repositorio UCC
OAI Identifier:oai:repository.ucc.edu.co:20.500.12494/45598
Acesso em linha:https://hdl.handle.net/20.500.12494/45598
Access Level:acceso abierto
Palavra-chave:SARS-CoV-2
Variantes
Evolución
Colombia
Variants
Evolution
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oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/45598
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network_name_str Colombia
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dc.title.none.fl_str_mv Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
title Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
spellingShingle Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
Laiton Donato, Katherine
SARS-CoV-2
Variantes
Evolución
Colombia
SARS-CoV-2
Variants
Evolution
Colombia
title_short Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
title_full Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
title_fullStr Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
title_full_unstemmed Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
title_sort Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
dc.creator.none.fl_str_mv Laiton Donato, Katherine
Usme Ciro, José Aldemar
Franco Muñoz, Carlos
Álvarez Díaz, Diego Alejandro
Ruiz Moreno, Hector A.
Reales Gonzalez, Jhonnatan
Prada, Diego A.
Corchuelo, Sheryll
Herrera Sepulveda, Maria T.
Naizaque, Julián Ricardo
Santamaría, Gerardo
Wiesner, Magdalena
Walteros, Diana Marcela
Ospina Martínez, Martha L.
Mercado Reyes, Marcela
author Laiton Donato, Katherine
author_facet Laiton Donato, Katherine
Usme Ciro, José Aldemar
Franco Muñoz, Carlos
Álvarez Díaz, Diego Alejandro
Ruiz Moreno, Hector A.
Reales Gonzalez, Jhonnatan
Prada, Diego A.
Corchuelo, Sheryll
Herrera Sepulveda, Maria T.
Naizaque, Julián Ricardo
Santamaría, Gerardo
Wiesner, Magdalena
Walteros, Diana Marcela
Ospina Martínez, Martha L.
Mercado Reyes, Marcela
author_role author
author2 Usme Ciro, José Aldemar
Franco Muñoz, Carlos
Álvarez Díaz, Diego Alejandro
Ruiz Moreno, Hector A.
Reales Gonzalez, Jhonnatan
Prada, Diego A.
Corchuelo, Sheryll
Herrera Sepulveda, Maria T.
Naizaque, Julián Ricardo
Santamaría, Gerardo
Wiesner, Magdalena
Walteros, Diana Marcela
Ospina Martínez, Martha L.
Mercado Reyes, Marcela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Variantes
Evolución
Colombia
SARS-CoV-2
Variants
Evolution
Colombia
topic SARS-CoV-2
Variantes
Evolución
Colombia
SARS-CoV-2
Variants
Evolution
Colombia
description COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-28
2022-07-07T14:39:06Z
2022-07-07T14:39:06Z
dc.type.none.fl_str_mv Artículos Científicos
http://purl.org/coar/resource_type/c_2df8fbb1
http://purl.org/coar/version/c_970fb48d4fbd8a85
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 2296-858X
10.3389/fmed.2021.697605
https://hdl.handle.net/20.500.12494/45598
Laiton Donato K, Usme Ciro JA, Franco Muñoz C, Alvarez Díaz DA, Ruiz Moreno HA, et al. (2021). Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K. Front. Med. 8:697605. doi: 10.3389/fmed.2021.697605.https://repository.ucc.edu.co/handle/20.500.12494/45598
identifier_str_mv 2296-858X
10.3389/fmed.2021.697605
Laiton Donato K, Usme Ciro JA, Franco Muñoz C, Alvarez Díaz DA, Ruiz Moreno HA, et al. (2021). Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K. Front. Med. 8:697605. doi: 10.3389/fmed.2021.697605.https://repository.ucc.edu.co/handle/20.500.12494/45598
url https://hdl.handle.net/20.500.12494/45598
dc.relation.none.fl_str_mv https://www.frontiersin.org/articles/10.3389/fmed.2021.697605/full
Frontiers in Medicine
Lee K, Worsnop CZ, Grépin KA, Kamradt-Scott A. Global coordination on cross-border travel and trade measures crucial to COVID-19 response. Lancet. (2020) 395:1593–5. doi: 10.1016/S0140-6736(20) 31032-1
GISAID. GISAID initiative. Adv Virus Res. (2020) 2008:1–7. Available online at: https://www.gisaid.org/
Rambaut A, Holmes EC, O’Toole Á, Hill V, McCrone JT, Ruis C, et al. A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology. Nat Microbiol. (2020) 5:1403–7. doi: 10.1038/s41564-020-0770-5
Centers for Disease Control Prevention, C. D. C. Emerging SARSCoV-2 variants. Cent Infect Dis Res Policy. (2020). Available online at: https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/ scientific-brief-emerging-variants.html (accessed March 2, 2021).
Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O’Toole Á, et al. Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity. Cell. (2021) 184:64–75.e11. doi: 10.1016/j.cell.2020.11.020
Rambaut A, Loman N, Pybus O, Barclay W, Barrett J, Carabell A, et al. Preliminary Genomic Characterisation of an Emergent SARS-CoV-2 Lineage in the UK Defined by a Novel Set of Spike Mutations. (2020). Available online at: https://virological.org/t/preliminary-genomic-characterisation-of-anemergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spikemutations/563 (accessed April17, 2021).
Voloch CM, da Silva Francisco R Jr, de Almeida LGP, Cardoso CC, Brustolini OJ, Gerber AL, et al. Genomic characterization of a novel SARSCoV-2 lineage from Rio de Janeiro, Brazil. J Virol. (2021) 1:e00119-21. doi: 10.1128/JVI.00119-21
Faria NR, Mellan TA, Whittaker C, Claro IM, Candido D da S, Mishra S, et al. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science. (2021) 372:815–21. doi: 10.1126/science.abh2644
Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature. (2021) 592:438–43. doi: 10.1038/s41586-021-03402-9
Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, et al. Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants. Elife. (2020) 9:e61312. doi: 10.7554/eLife.61312.sa2
Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. (2021). 592:616–22 doi: 10.1038/s41586-021-03324-6
Liu Z, VanBlargan LA, Bloyet L-M, Rothlauf PW, Chen RE, Stumpf S, et al. Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Cell Host Microbe. (2021) 29:477–88.e4. doi: 10.1016/j.chom.2021.01.014
Laiton-Donato K, Villabona-Arenas CJ, Usme-Ciro JA, Franco-Muñoz C, Álvarez-Díaz DA, Villabona-Arenas LS, et al. Genomic epidemiology of severe acute respiratory syndrome coronavirus 2, Colombia. Emerg Infect Dis. (2020) 26:2854–62. doi: 10.3201/eid2612.202969
Instito Nacional de Salud. Estrategia de Caracterización Genómica SARSCoV-2, COLOMBIA. 1–12. (2021). Available online at: http://www.ins.gov. co/BibliotecaDigital/Estrategia-de-caracterizacion-genomica-SARS-CoV2_ Colombia.pdf (accessed April 18, 2021).
Tyson JR, James P, Stoddart D, Sparks N, Wickenhagen A, Hall G, et al. Improvements to the ARTIC multiplex PCR method for SARS-CoV-2 genome sequencing using nanopore. bioRxiv Prepr Serv Biol [Preprint]. (2020). doi: 10.1101/2020.09.04.283077
Martin DP, Murrell B, Golden M, Khoosal A, Muhire B. RDP4: detection and analysis of recombination patterns in virus genomes. Virus Evol. (2015) 1:vev003. doi: 10.1093/ve/vev003
Delport W, Poon AFY, Frost SDW, Kosakovsky Pond SL. Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology. Bioinformatics. (2010) 26:2455–7. doi: 10.1093/bioinformatics/btq429
Nguyen L-T, Schmidt HA, von Haeseler A, Minh BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. (2015) 32:268–74. doi: 10.1093/molbev/msu300
Guindon S, Dufayard J-F, Lefort V, Anisimova M, Hordijk W, Gascuel O, et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. (2010) 59:307–21. doi: 10.1093/sysbio/syq010
Greaney AJ, Loes AN, Crawford KHD, Starr TN, Malone KD, Chu HY, et al. Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies. Cell Host Microbe. (2021) 29:463–76.e6. doi: 10.1016/j.chom.2021.02.003
Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, et al. SARS-CoV-2 evolution during treatment of chronic infection. Nature. (2021) 592:277–82. doi: 10.1038/s41586-021-03291-y
Rees-Spear C, Muir L, Griffith SA, Heaney J, Aldon Y, Snitselaar JL, et al. The effect of spike mutations on SARS-CoV-2 neutralization. Cell Rep. (2021) 34:108890. doi: 10.1016/j.celrep.2021.108890
Dumonteil E, Herrera C. Polymorphism and selection pressure of SARS-CoV-2 vaccine and diagnostic antigens: implications for immune evasion and serologic diagnostic performance. Pathogens. (2020) 9:584. doi: 10.3390/pathogens9070584
Cele S, Gazy I, Jackson L, Hwa S-H, Tegally H, Lustig G, et al. Escape of SARSCoV-2 501Y.V2 variants from neutralization by convalescent plasma. Nature. (2021) 593:142–6. doi: 10.1038/s41586-021-03471-w
Wibmer CK, Ayres F, Hermanus T, Madzivhandila M, Kgagudi P, Oosthuysen B, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nat Med. (2021) 27:622–5. doi: 10.1101/2021.01.18.427166
Tarke A, Sidney J, Methot N, Zhang Y, Dan JM, Goodwin B, et al. Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees. bioRxiv [Preprint]. (2021) 2021.02.27.433180. doi: 10.1101/2021.02.27.433180
Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, et al. Persistence and evolution of SARS-CoV-2 in an immunocompromised host. N Engl J Med. (2020) 383:2291–3. doi: 10.1056/NEJMc2031364
Hu J, Peng P, Wang K, Fang L, Luo F, Jin A, et al. Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies. Cell Mol Immunol. (2021) 18:1061–3. doi: 10.1101/2021.01.22.427749
dc.rights.none.fl_str_mv Atribución – Sin Derivar
info:eu-repo/semantics/openAccess
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rights_invalid_str_mv Atribución – Sin Derivar
http://purl.org/coar/access_right/c_abf2
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dc.publisher.none.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta
Bathri N. Vajravelu
Medicina
Santa Marta
publisher.none.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta
Bathri N. Vajravelu
Medicina
Santa Marta
dc.source.none.fl_str_mv reponame:Repositorio UCC
instname:Universidad Cooperativa de Colombia
instacron:Universidad Cooperativa de Colombia
instname_str Universidad Cooperativa de Colombia
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reponame_str Repositorio UCC
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spelling Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484KLaiton Donato, KatherineUsme Ciro, José AldemarFranco Muñoz, CarlosÁlvarez Díaz, Diego AlejandroRuiz Moreno, Hector A.Reales Gonzalez, JhonnatanPrada, Diego A.Corchuelo, SheryllHerrera Sepulveda, Maria T.Naizaque, Julián RicardoSantamaría, GerardoWiesner, MagdalenaWalteros, Diana MarcelaOspina Martínez, Martha L.Mercado Reyes, MarcelaSARS-CoV-2VariantesEvoluciónColombiaSARS-CoV-2VariantsEvolutionColombiaCOVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000318507https://orcid.org/0000-0002-8093-0544https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000008981jose.usmec@campusucc.edu.cohttps://scholar.google.com.co/citations?user=cU2KyT4AAAAJ&hl=enUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa MartaBathri N. VajraveluMedicinaSanta Marta2022-07-07T14:39:06Z2022-07-07T14:39:06Z2021-06-28Artículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6application/pdfapplication/pdf2296-858X10.3389/fmed.2021.697605https://hdl.handle.net/20.500.12494/45598Laiton Donato K, Usme Ciro JA, Franco Muñoz C, Alvarez Díaz DA, Ruiz Moreno HA, et al. (2021). Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K. Front. Med. 8:697605. doi: 10.3389/fmed.2021.697605.https://repository.ucc.edu.co/handle/20.500.12494/45598https://www.frontiersin.org/articles/10.3389/fmed.2021.697605/fullFrontiers in MedicineLee K, Worsnop CZ, Grépin KA, Kamradt-Scott A. Global coordination on cross-border travel and trade measures crucial to COVID-19 response. Lancet. (2020) 395:1593–5. doi: 10.1016/S0140-6736(20) 31032-1GISAID. GISAID initiative. Adv Virus Res. (2020) 2008:1–7. Available online at: https://www.gisaid.org/Rambaut A, Holmes EC, O’Toole Á, Hill V, McCrone JT, Ruis C, et al. A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology. Nat Microbiol. (2020) 5:1403–7. doi: 10.1038/s41564-020-0770-5Centers for Disease Control Prevention, C. D. C. Emerging SARSCoV-2 variants. Cent Infect Dis Res Policy. (2020). Available online at: https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/ scientific-brief-emerging-variants.html (accessed March 2, 2021).Volz E, Hill V, McCrone JT, Price A, Jorgensen D, O’Toole Á, et al. Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity. Cell. (2021) 184:64–75.e11. doi: 10.1016/j.cell.2020.11.020Rambaut A, Loman N, Pybus O, Barclay W, Barrett J, Carabell A, et al. Preliminary Genomic Characterisation of an Emergent SARS-CoV-2 Lineage in the UK Defined by a Novel Set of Spike Mutations. (2020). Available online at: https://virological.org/t/preliminary-genomic-characterisation-of-anemergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spikemutations/563 (accessed April17, 2021).Voloch CM, da Silva Francisco R Jr, de Almeida LGP, Cardoso CC, Brustolini OJ, Gerber AL, et al. Genomic characterization of a novel SARSCoV-2 lineage from Rio de Janeiro, Brazil. J Virol. (2021) 1:e00119-21. doi: 10.1128/JVI.00119-21Faria NR, Mellan TA, Whittaker C, Claro IM, Candido D da S, Mishra S, et al. Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil. Science. (2021) 372:815–21. doi: 10.1126/science.abh2644Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, et al. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature. (2021) 592:438–43. doi: 10.1038/s41586-021-03402-9Weisblum Y, Schmidt F, Zhang F, DaSilva J, Poston D, Lorenzi JC, et al. Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants. Elife. (2020) 9:e61312. doi: 10.7554/eLife.61312.sa2Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. (2021). 592:616–22 doi: 10.1038/s41586-021-03324-6Liu Z, VanBlargan LA, Bloyet L-M, Rothlauf PW, Chen RE, Stumpf S, et al. Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Cell Host Microbe. (2021) 29:477–88.e4. doi: 10.1016/j.chom.2021.01.014Laiton-Donato K, Villabona-Arenas CJ, Usme-Ciro JA, Franco-Muñoz C, Álvarez-Díaz DA, Villabona-Arenas LS, et al. Genomic epidemiology of severe acute respiratory syndrome coronavirus 2, Colombia. Emerg Infect Dis. (2020) 26:2854–62. doi: 10.3201/eid2612.202969Instito Nacional de Salud. Estrategia de Caracterización Genómica SARSCoV-2, COLOMBIA. 1–12. (2021). Available online at: http://www.ins.gov. co/BibliotecaDigital/Estrategia-de-caracterizacion-genomica-SARS-CoV2_ Colombia.pdf (accessed April 18, 2021).Tyson JR, James P, Stoddart D, Sparks N, Wickenhagen A, Hall G, et al. Improvements to the ARTIC multiplex PCR method for SARS-CoV-2 genome sequencing using nanopore. bioRxiv Prepr Serv Biol [Preprint]. (2020). doi: 10.1101/2020.09.04.283077Martin DP, Murrell B, Golden M, Khoosal A, Muhire B. RDP4: detection and analysis of recombination patterns in virus genomes. Virus Evol. (2015) 1:vev003. doi: 10.1093/ve/vev003Delport W, Poon AFY, Frost SDW, Kosakovsky Pond SL. Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology. Bioinformatics. (2010) 26:2455–7. doi: 10.1093/bioinformatics/btq429Nguyen L-T, Schmidt HA, von Haeseler A, Minh BQ. IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Mol Biol Evol. (2015) 32:268–74. doi: 10.1093/molbev/msu300Guindon S, Dufayard J-F, Lefort V, Anisimova M, Hordijk W, Gascuel O, et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol. (2010) 59:307–21. doi: 10.1093/sysbio/syq010Greaney AJ, Loes AN, Crawford KHD, Starr TN, Malone KD, Chu HY, et al. Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies. Cell Host Microbe. (2021) 29:463–76.e6. doi: 10.1016/j.chom.2021.02.003Kemp SA, Collier DA, Datir RP, Ferreira IATM, Gayed S, Jahun A, et al. SARS-CoV-2 evolution during treatment of chronic infection. Nature. (2021) 592:277–82. doi: 10.1038/s41586-021-03291-yRees-Spear C, Muir L, Griffith SA, Heaney J, Aldon Y, Snitselaar JL, et al. The effect of spike mutations on SARS-CoV-2 neutralization. Cell Rep. (2021) 34:108890. doi: 10.1016/j.celrep.2021.108890Dumonteil E, Herrera C. Polymorphism and selection pressure of SARS-CoV-2 vaccine and diagnostic antigens: implications for immune evasion and serologic diagnostic performance. Pathogens. (2020) 9:584. doi: 10.3390/pathogens9070584Cele S, Gazy I, Jackson L, Hwa S-H, Tegally H, Lustig G, et al. Escape of SARSCoV-2 501Y.V2 variants from neutralization by convalescent plasma. Nature. (2021) 593:142–6. doi: 10.1038/s41586-021-03471-wWibmer CK, Ayres F, Hermanus T, Madzivhandila M, Kgagudi P, Oosthuysen B, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nat Med. (2021) 27:622–5. doi: 10.1101/2021.01.18.427166Tarke A, Sidney J, Methot N, Zhang Y, Dan JM, Goodwin B, et al. Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees. bioRxiv [Preprint]. (2021) 2021.02.27.433180. doi: 10.1101/2021.02.27.433180Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, et al. Persistence and evolution of SARS-CoV-2 in an immunocompromised host. N Engl J Med. (2020) 383:2291–3. doi: 10.1056/NEJMc2031364Hu J, Peng P, Wang K, Fang L, Luo F, Jin A, et al. Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies. Cell Mol Immunol. (2021) 18:1061–3. doi: 10.1101/2021.01.22.4277498Atribución – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2reponame:Repositorio UCCinstname:Universidad Cooperativa de Colombiainstacron:Universidad Cooperativa de Colombia2024-08-11T03:49:46Z
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