Functional hubs in mild cognitive impairment

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to invest...

Descripción completa

Detalles Bibliográficos
Autores: Navas, Adrián, Papo, David, Boccaletti, Stefano, Del-Pozo, F., Bajo, Ricardo, Maestú, Fernando, Martínez, J. H., Gil, Pablo, Sendiña-Nadal, Irene, Buldú, Javier M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Colombia
Institución:Universidad del Rosario
Repositorio:Repositorio EdocUR - U. Rosario
Idioma:inglés
OAI Identifier:oai:repository.urosario.edu.co:10336/24334
Acceso en línea:https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
Access Level:acceso abierto
Palabra clave:Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
id CO_71daadcfdb72fcea893cd8c50dca0142
oai_identifier_str oai:repository.urosario.edu.co:10336/24334
network_acronym_str CO
network_name_str Colombia
repository_id_str
spelling Functional hubs in mild cognitive impairmentNavas, AdriánPapo, DavidBoccaletti, StefanoDel-Pozo, F.Bajo, RicardoMaestú, FernandoMartínez, J. H.Gil, PabloSendiña-Nadal, IreneBuldú, Javier M.Brain mappingElectric network topologyMagnetoencephalographyAlzheimer's diseaseBrain networksCentralityMild cognitive impairmentsMild cognitive impairments (MCI)Random structuresShort-term memory tasksSynchronization likelihoodsNeurodegenerative diseasesCentralityFunctional brain networksHub characterizationMild cognitive impairmentSynchronization likelihoodWe investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.World Scientific Publishing Co. Pte Ltd20152020-05-26T00:11:48Zinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1142/S0218127415500340https://repository.urosario.edu.co/handle/10336/24334reponame:Repositorio EdocUR - U. Rosarioinstname:Universidad del Rosarioinstacron:Universidad del Rosarioenghttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989dinfo:eu-repo/semantics/openAccess2022-05-02T07:37:14Z
dc.title.none.fl_str_mv Functional hubs in mild cognitive impairment
title Functional hubs in mild cognitive impairment
spellingShingle Functional hubs in mild cognitive impairment
Navas, Adrián
Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
title_short Functional hubs in mild cognitive impairment
title_full Functional hubs in mild cognitive impairment
title_fullStr Functional hubs in mild cognitive impairment
title_full_unstemmed Functional hubs in mild cognitive impairment
title_sort Functional hubs in mild cognitive impairment
dc.creator.none.fl_str_mv Navas, Adrián
Papo, David
Boccaletti, Stefano
Del-Pozo, F.
Bajo, Ricardo
Maestú, Fernando
Martínez, J. H.
Gil, Pablo
Sendiña-Nadal, Irene
Buldú, Javier M.
author Navas, Adrián
author_facet Navas, Adrián
Papo, David
Boccaletti, Stefano
Del-Pozo, F.
Bajo, Ricardo
Maestú, Fernando
Martínez, J. H.
Gil, Pablo
Sendiña-Nadal, Irene
Buldú, Javier M.
author_role author
author2 Papo, David
Boccaletti, Stefano
Del-Pozo, F.
Bajo, Ricardo
Maestú, Fernando
Martínez, J. H.
Gil, Pablo
Sendiña-Nadal, Irene
Buldú, Javier M.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
topic Brain mapping
Electric network topology
Magnetoencephalography
Alzheimer's disease
Brain networks
Centrality
Mild cognitive impairments
Mild cognitive impairments (MCI)
Random structures
Short-term memory tasks
Synchronization likelihoods
Neurodegenerative diseases
Centrality
Functional brain networks
Hub characterization
Mild cognitive impairment
Synchronization likelihood
description We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures. © 2015 World Scientific Publishing Company.
publishDate 2015
dc.date.none.fl_str_mv 2015
2020-05-26T00:11:48Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
url https://doi.org/10.1142/S0218127415500340
https://repository.urosario.edu.co/handle/10336/24334
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928537119&doi=10.1142%2fS0218127415500340&partnerID=40&md5=08d165cfa85de2bfd833ec700526989d
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv World Scientific Publishing Co. Pte Ltd
publisher.none.fl_str_mv World Scientific Publishing Co. Pte Ltd
dc.source.none.fl_str_mv reponame:Repositorio EdocUR - U. Rosario
instname:Universidad del Rosario
instacron:Universidad del Rosario
instname_str Universidad del Rosario
instacron_str Universidad del Rosario
institution Universidad del Rosario
reponame_str Repositorio EdocUR - U. Rosario
collection Repositorio EdocUR - U. Rosario
_version_ 1825051701160181760
score 15,198674

Similares en LA Referencia