Bacteriophage-antibiotic combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities
Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations again...
| Autores: | , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Colombia |
| Institución: | Universidad El Bosque |
| Repositorio: | Repositorio U. El Bosque |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unbosque.edu.co:20.500.12495/3914 |
| Acceso en línea: | http://hdl.handle.net/20.500.12495/3914 https://doi.org/10.1128/aac.00993-20 https://repositorio.unbosque.edu.co |
| Access Level: | acceso abierto |
| Palabra clave: | Bacteriophage-antibiotic combinations Bacteriophages Daptomycin Enterococcus faecium |
| Sumario: | Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance. |
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