GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Repositório Institucional da FIOCRUZ (ARCA) |
| Idioma: | inglés |
| OAI Identifier: | oai:arca.fiocruz.br:icict/40782 |
| Acceso en línea: | https://arca.fiocruz.br/handle/icict/40782 |
| Access Level: | acceso abierto |
| Palabra clave: | Mikania cordifolia Limoneno Resistência bacteriana Antibióticos Modulação Limonene Bacterial resistance Antibiotics Modulation |
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| dc.title.none.fl_str_mv |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| title |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| spellingShingle |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains Araújo, Ana Carolina Justino de Mikania cordifolia Limoneno Resistência bacteriana Antibióticos Modulação Mikania cordifolia Limonene Bacterial resistance Antibiotics Modulation |
| title_short |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| title_full |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| title_fullStr |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| title_full_unstemmed |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| title_sort |
GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains |
| dc.creator.none.fl_str_mv |
Araújo, Ana Carolina Justino de Freitas, Priscilla Ramos Barbosa, Cristina Rodrigues dos Santos Muniz, Débora Feitosa Rocha, Janaína Esmeraldo Silva, Ana Cristina Albuquerque da Tintino, Cícera Datiane de Morais Oliveira Ribeiro Filho, Jaime Silva, Luiz Everson da Confortin, Camila Amaral, Wanderlei do Deschamps, Cícero Barbosa Filho, José Maria Lima, Natanael Teles Ramos de Tintino, Saulo Relison Coutinho, Henrique Douglas Melo |
| author |
Araújo, Ana Carolina Justino de |
| author_facet |
Araújo, Ana Carolina Justino de Freitas, Priscilla Ramos Barbosa, Cristina Rodrigues dos Santos Muniz, Débora Feitosa Rocha, Janaína Esmeraldo Silva, Ana Cristina Albuquerque da Tintino, Cícera Datiane de Morais Oliveira Ribeiro Filho, Jaime Silva, Luiz Everson da Confortin, Camila Amaral, Wanderlei do Deschamps, Cícero Barbosa Filho, José Maria Lima, Natanael Teles Ramos de Tintino, Saulo Relison Coutinho, Henrique Douglas Melo |
| author_role |
author |
| author2 |
Freitas, Priscilla Ramos Barbosa, Cristina Rodrigues dos Santos Muniz, Débora Feitosa Rocha, Janaína Esmeraldo Silva, Ana Cristina Albuquerque da Tintino, Cícera Datiane de Morais Oliveira Ribeiro Filho, Jaime Silva, Luiz Everson da Confortin, Camila Amaral, Wanderlei do Deschamps, Cícero Barbosa Filho, José Maria Lima, Natanael Teles Ramos de Tintino, Saulo Relison Coutinho, Henrique Douglas Melo |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.subject.other.none.fl_str_mv |
Mikania cordifolia Limoneno Resistência bacteriana Antibióticos Modulação |
| topic |
Mikania cordifolia Limoneno Resistência bacteriana Antibióticos Modulação Mikania cordifolia Limonene Bacterial resistance Antibiotics Modulation |
| dc.subject.en.none.fl_str_mv |
Mikania cordifolia Limonene Bacterial resistance Antibiotics Modulation |
| description |
Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-04-15T17:14:12Z |
| dc.date.available.fl_str_mv |
2020-04-15T17:14:12Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ARAÚJO, Ana Carolina Justino de et al. GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains. Food and Chemical Toxicology, 2020. |
| dc.identifier.uri.fl_str_mv |
https://arca.fiocruz.br/handle/icict/40782 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.fct.2019.111023 |
| identifier_str_mv |
ARAÚJO, Ana Carolina Justino de et al. GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains. Food and Chemical Toxicology, 2020. 10.1016/j.fct.2019.111023 |
| url |
https://arca.fiocruz.br/handle/icict/40782 |
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eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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2020-04-15T17:14:12Z2020-04-15T17:14:12Z2020ARAÚJO, Ana Carolina Justino de et al. GC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strains. Food and Chemical Toxicology, 2020.https://arca.fiocruz.br/handle/icict/4078210.1016/j.fct.2019.111023engElsevierMikania cordifoliaLimonenoResistência bacterianaAntibióticosModulaçãoMikania cordifoliaLimoneneBacterial resistanceAntibioticsModulationGC-MS-FID characterization and antibacterial activity of the Mikania cordifolia essential oil and limonene against MDR strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRegional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Federal University of Pernambuco. Department of Antibiotics. Recife, PE, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Paraná. Post Graduation course of Sustainable Territorial Development. Matinhos, PR, Brazil.Federal University of Paraná. Post Graduation course of Sustainable Territorial Development. Matinhos, PR, Brazil.Federal University of Paraná. Department of Chemical Technology. Curitiba, PR, Brazil.Federal University of Paraná. Post Graduation course of Agronomy. Curitiba, PR, Brazil.Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.Federal University of Paraiba. Department of Pharmacy. João Pessoa, PB, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.Regional University of Cariri. Department of Biological Chemistry. Crato, CE, Brazil.The present study evaluated the effect of the essential oil of Mikania cordifolia (EOMc) and its major constituent limonene alone or associated with antibacterial drugs against Multidrug Resistant Bacteria (MDR). To evaluate the antibacterial activity, the minimum inhibitory concentrations (MIC) of the oil and limonene against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus were determined. The antibiotic-modulating activity was assessed using subinhibitory concentrations (MIC/8) of these substances in combination with conventional antibacterial drugs. Although no relevant antibacterial activity of the natural products was detected, both substances modulated the action of antibiotics against resistant bacteria. The EOMc demonstrated the best modulating effect against P. aeruginosa, presenting synergistic effects when associated with gentamicin and norfloxacin. In addition, the oil reduced the MIC of norfloxacin against E. coli as well as reduced the MIC of gentamicin against S. aureus. On the other hand, the best effect of limonene was obtained against S. aureus. Thus, it is concluded that the essential oil Mikania cordifolia and the isolated compound limonene do not have clinically significant antibacterial effect, but modulate the action of antibiotics against MDR bacteria.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZAraújo, Ana Carolina Justino deFreitas, Priscilla RamosBarbosa, Cristina Rodrigues dos SantosMuniz, Débora FeitosaRocha, Janaína EsmeraldoSilva, Ana Cristina Albuquerque daTintino, Cícera Datiane de Morais OliveiraRibeiro Filho, JaimeSilva, Luiz Everson daConfortin, CamilaAmaral, Wanderlei doDeschamps, CíceroBarbosa Filho, José MariaLima, Natanael Teles Ramos deTintino, Saulo RelisonCoutinho, Henrique Douglas MeloLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/5cf7027c-a9b0-4a7e-b81f-9cd61f8a4261/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALAraujo Justino GC-MS-FID characterization...pdfAraujo Justino GC-MS-FID characterization...pdfapplication/pdf878455https://arca.fiocruz.br/bitstreams/04a6252e-ece4-40ef-98d3-4ef300b4930c/download6b94be79b73d0713f3078cee101ac737MD52trueAnonymousREADTEXTAraujo Justino GC-MS-FID characterization...pdf.txtAraujo Justino GC-MS-FID characterization...pdf.txtExtracted texttext/plain34211https://arca.fiocruz.br/bitstreams/183ba5c8-1c7f-46dc-8852-780ddc0084f4/download185ab07bf5d7323d23d0cbc8c5219da2MD59falseAnonymousREADTHUMBNAILAraujo Justino GC-MS-FID characterization...pdf.jpgAraujo Justino GC-MS-FID characterization...pdf.jpgGenerated Thumbnailimage/jpeg33770https://arca.fiocruz.br/bitstreams/6364a382-bcfe-4e58-8876-83984ae7b7c3/download245c714f590682a023334a53c008ae0cMD510falseAnonymousREADicict/407822025-12-11 08:31:55.758open.accessoai:arca.fiocruz.br:icict/40782https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-11T11:31:55Repositório Institucional da FIOCRUZ (ARCA) - 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