Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth
This work has been supported by CNPq and Fiocruz.
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Repositório Institucional da FIOCRUZ (ARCA) |
| Idioma: | portugués |
| OAI Identifier: | oai:arca.fiocruz.br:icict/15601 |
| Acceso en línea: | https://arca.fiocruz.br/handle/icict/15601 |
| Access Level: | acceso abierto |
| Palabra clave: | Citral Crithidia fasciculata Eugenol Thymol Trypanosoma cruzi Trypanosomatid |
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| dc.title.none.fl_str_mv |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| title |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| spellingShingle |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth Azeredo, Camila Maria Oliveira de Citral Crithidia fasciculata Eugenol Thymol Trypanosoma cruzi Trypanosomatid |
| title_short |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| title_full |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| title_fullStr |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| title_full_unstemmed |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| title_sort |
Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth |
| dc.creator.none.fl_str_mv |
Azeredo, Camila Maria Oliveira de Soares, Maurilio José |
| author |
Azeredo, Camila Maria Oliveira de |
| author_facet |
Azeredo, Camila Maria Oliveira de Soares, Maurilio José |
| author_role |
author |
| author2 |
Soares, Maurilio José |
| author2_role |
author |
| dc.subject.en.none.fl_str_mv |
Citral Crithidia fasciculata Eugenol Thymol Trypanosoma cruzi Trypanosomatid |
| topic |
Citral Crithidia fasciculata Eugenol Thymol Trypanosoma cruzi Trypanosomatid |
| description |
This work has been supported by CNPq and Fiocruz. |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
| dc.date.accessioned.fl_str_mv |
2016-09-02T18:10:57Z |
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2016-09-02T18:10:57Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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AZEREDO, Camila M. O.; SOARES, Maurilio J. Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 5, p. 762-768, Oct. 2013. |
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https://arca.fiocruz.br/handle/icict/15601 |
| dc.identifier.issn.none.fl_str_mv |
0102-695X |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-695X2013000500007 |
| identifier_str_mv |
AZEREDO, Camila M. O.; SOARES, Maurilio J. Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 5, p. 762-768, Oct. 2013. 0102-695X 10.1590/S0102-695X2013000500007 |
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https://arca.fiocruz.br/handle/icict/15601 |
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por |
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por |
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openAccess |
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2016-09-02T18:10:57Z2016-09-02T18:10:57Z2013AZEREDO, Camila M. O.; SOARES, Maurilio J. Combination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growth. Revista Brasileira de Farmacognosia, Curitiba, v. 23, n. 5, p. 762-768, Oct. 2013.0102-695Xhttps://arca.fiocruz.br/handle/icict/1560110.1590/S0102-695X2013000500007This work has been supported by CNPq and Fiocruz.Oswaldo Cruz Fundation. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brazil.Oswaldo Cruz Fundation. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brazil.We analyzed the effect of the combination of citral, eugenol and thymol, respectively the main constituents of essential oils of Cympobogon citratus (DC) Stapf, Poaceae (lemon grass), Syzygium aromaticum (L.) Merr. & L.M. Perry, Myrtaceae (clove) and Thymus vulgaris L., Lamiaceae (thyme), on the proliferation of the trypanosomatids Crithidia fasciculata and Trypanosoma cruzi. The constituents were initially added individually at different concentrations to C. fasciculata cultures to estimate the IC50/24h. Concentrations in a triple combination were about 2 times and 16.5 times lower against C. fasciculata and T. cruzi, respectively, as compared to isolated compounds. Incubation of C. fasciculata with the trypanocydal agent benznidazole did not affect parasite growth at concentrations up to 500 µg/ml, but the IC50 of this drug against T. cruziwas 15.8 µg/ml, a value about 2-5 times higher than that of constituents in the triple combination. Analysis of treated C. fasciculata by scanning electron microscopy showed rounding of the cell body. Our data show that combination of essential oil constituents resulted in increased inhibitory activity on growth of both non-pathogenic and pathogenic trypanosomatid species and indicate that the non-patogenic C. fasciculata may represent a resistant model for drug screening in trypanosomatids.porCombination of the essential oil constituents citral, eugenol and thymol enhance their inhibitory effect on Crithidia fasciculata and Trypanosoma cruzi growthinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCitralCrithidia fasciculataEugenolThymolTrypanosoma cruziTrypanosomatidinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZAzeredo, Camila Maria Oliveira deSoares, Maurilio JoséLICENSElicense.txtlicense.txttext/plain; charset=utf-83074https://arca.fiocruz.br/bitstreams/99d8b12e-645f-45da-a919-610ddcee4201/download0271fb68963c017aa933c7aff60379f4MD51falseAnonymousREADORIGINALCombination of the essential oil constituents citral, eugenol and thymol.pdfCombination of the essential oil constituents citral, eugenol and thymol.pdfapplication/pdf895900https://arca.fiocruz.br/bitstreams/b2bcbd26-2f48-42a8-898b-1d349dd151a1/download32525205d511b6991bbd8e277807f893MD52trueAnonymousREADTEXTCombination of the essential oil constituents citral, eugenol and thymol.pdf.txtCombination of the essential oil constituents citral, eugenol and thymol.pdf.txtExtracted texttext/plain34519https://arca.fiocruz.br/bitstreams/28ddcc25-49ca-473d-9c82-249f901aff2a/downloade1e53c6c639191af865cd647e8f0c91fMD57falseAnonymousREADTHUMBNAILCombination of the essential oil constituents citral, eugenol and thymol.pdf.jpgCombination of the essential oil constituents citral, eugenol and thymol.pdf.jpgGenerated Thumbnailimage/jpeg40114https://arca.fiocruz.br/bitstreams/a3c55f6f-9e18-499e-a98b-4f6dd92f8e05/download3b558197fe1532274893d425b1b79d0eMD58falseAnonymousREADicict/156012025-12-10 13:48:06.771open.accessoai:arca.fiocruz.br:icict/15601https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T16:48:06Repositório Institucional da FIOCRUZ (ARCA) - 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