Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds

In the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Ju...

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Autores: Rodrigues, L. A., Almeida, A. A., Agrizii, A. P., Pacheco, N., Carvalho, B. C.R., Zanatta, A. C. [UNESP], Kohlhoff, M., Torres, C. M.M.E., Bressan, G. C., Leite, J. P.V.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositório:Repositório Institucional da UNESP
Idioma:inglês
OAI Identifier:oai:repositorio.unesp.br:11449/300839
Acesso em linha:http://dx.doi.org/10.1080/14786419.2023.2225689
https://hdl.handle.net/11449/300839
Access Level:Acceso aberto
Palavra-chave:Casearia arborea
Cytotoxic
dereplication
GNPS
Sorocea hilarii
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spelling Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compoundsCasearia arboreaCytotoxicdereplicationGNPSSorocea hilariiIn the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Jurkat). After bioassay-guided fractionation, the bioactive fractions were submitted to the dereplication study via High-performance Liquid Chromatography, connected to High-resolution Mass Spectrometry (HPLC-ESI-QTOF/MS) analysis, combined with a Global Natural Products Social Molecular Networking (GNPS) tool. A combination of bioactivity-guided and dereplication approaches resulted in the putative annotation of 27 clerodane diterpenes and 9 flavonoids as main compounds present in the cytotoxic fractions of C. arborea. Regarding the active fraction of S. hilarii, 10 megastigmans, 17 spirostane steroids derivatives and 2 lignans were putatively identified. In conclusion, Casearia arborea and Sorocea hilarii are potential sources of antitumor compounds.Departamento de Bioquímica e Biologia Molecular Universidade Federal de Viçosa, Minas GeraisUniversidade Estadual Paulista (Unesp) Instituto de Química, São PauloRene Rachou Research Center Fiocruz, Minas GeraisDepartamento de Engenharia Florestal Universidade Federal de Viçosa, Minas GeraisUniversidade Estadual Paulista (Unesp) Instituto de Química, São PauloUniversidade Federal de Viçosa (UFV)Universidade Estadual Paulista (UNESP)Fiocruz2025-04-29T18:50:45Z2024-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1950-1955http://dx.doi.org/10.1080/14786419.2023.2225689Natural Product Research, v. 38, n. 11, p. 1950-1955, 2024.1478-64271478-6419https://hdl.handle.net/11449/30083910.1080/14786419.2023.22256892-s2.0-85162979111Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Researchinfo:eu-repo/semantics/openAccessRodrigues, L. A.Almeida, A. A.Agrizii, A. P.Pacheco, N.Carvalho, B. C.R.Zanatta, A. C. [UNESP]Kohlhoff, M.Torres, C. M.M.E.Bressan, G. C.Leite, J. P.V.2025-05-28T05:46:50Zoai:repositorio.unesp.br:11449/300839Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-28T05:46:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
title Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
spellingShingle Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
Rodrigues, L. A.
Casearia arborea
Cytotoxic
dereplication
GNPS
Sorocea hilarii
title_short Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
title_full Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
title_fullStr Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
title_full_unstemmed Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
title_sort Cytotoxic screening of plants from the Brazilian Atlantic Forest has led to the identification of Casearia arborea and Sorocea hilarii as sources of antitumor compounds
dc.creator.none.fl_str_mv Rodrigues, L. A.
Almeida, A. A.
Agrizii, A. P.
Pacheco, N.
Carvalho, B. C.R.
Zanatta, A. C. [UNESP]
Kohlhoff, M.
Torres, C. M.M.E.
Bressan, G. C.
Leite, J. P.V.
author Rodrigues, L. A.
author_facet Rodrigues, L. A.
Almeida, A. A.
Agrizii, A. P.
Pacheco, N.
Carvalho, B. C.R.
Zanatta, A. C. [UNESP]
Kohlhoff, M.
Torres, C. M.M.E.
Bressan, G. C.
Leite, J. P.V.
author_role author
author2 Almeida, A. A.
Agrizii, A. P.
Pacheco, N.
Carvalho, B. C.R.
Zanatta, A. C. [UNESP]
Kohlhoff, M.
Torres, C. M.M.E.
Bressan, G. C.
Leite, J. P.V.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Viçosa (UFV)
Universidade Estadual Paulista (UNESP)
Fiocruz
dc.subject.por.fl_str_mv Casearia arborea
Cytotoxic
dereplication
GNPS
Sorocea hilarii
topic Casearia arborea
Cytotoxic
dereplication
GNPS
Sorocea hilarii
description In the present study, we have evaluated the cytotoxic activity of 282 extracts from 72 native plant species of the Brazilian Atlantic Forest biome. As a result, Casearia arborea and Sorocea hilarii leaves extracts showed cytotoxic activity against three tumour cell lines tested (B16F10, SW480 and Jurkat). After bioassay-guided fractionation, the bioactive fractions were submitted to the dereplication study via High-performance Liquid Chromatography, connected to High-resolution Mass Spectrometry (HPLC-ESI-QTOF/MS) analysis, combined with a Global Natural Products Social Molecular Networking (GNPS) tool. A combination of bioactivity-guided and dereplication approaches resulted in the putative annotation of 27 clerodane diterpenes and 9 flavonoids as main compounds present in the cytotoxic fractions of C. arborea. Regarding the active fraction of S. hilarii, 10 megastigmans, 17 spirostane steroids derivatives and 2 lignans were putatively identified. In conclusion, Casearia arborea and Sorocea hilarii are potential sources of antitumor compounds.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-01
2025-04-29T18:50:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2023.2225689
Natural Product Research, v. 38, n. 11, p. 1950-1955, 2024.
1478-6427
1478-6419
https://hdl.handle.net/11449/300839
10.1080/14786419.2023.2225689
2-s2.0-85162979111
url http://dx.doi.org/10.1080/14786419.2023.2225689
https://hdl.handle.net/11449/300839
identifier_str_mv Natural Product Research, v. 38, n. 11, p. 1950-1955, 2024.
1478-6427
1478-6419
10.1080/14786419.2023.2225689
2-s2.0-85162979111
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1950-1955
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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score 15.228081

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