The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl

Two new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata - an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activit...

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Detalhes bibliográficos
Autores: Biasetto, Carolina R. [UNESP], Somensi, Andressa [UNESP], Sordi, Renata [UNESP], Chapla, Vanessa M., Ebrahimi, Samad N., Silva, Geraldo H., Teles, Helder L., Bolzani, Vanderlan da S. [UNESP], Young, Maria Cláudia M., Pfenning, Ludwig H., Araujo, Angela R. [UNESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/201524
Acesso em linha:http://dx.doi.org/10.1016/j.phytol.2020.01.019
http://hdl.handle.net/11449/201524
Access Level:acceso abierto
Palavra-chave:Acetylcholinesterase inhibitors.
Antifungal
Koninginin
Phomopsis stipata
Polyketides
Descrição
Resumo:Two new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata - an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activities of these compounds were evaluated using TLC bioautographic assays. Compounds 1 and 2 displayed moderate antifungal activity and compound 1 showed acetylcholinesterase inhibitory activity.

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