Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum

CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), project PROMOB-Fapitec/CApES) and UFS.

Detalles Bibliográficos
Autores: Lima, Rafaely Nascimento, Ribeiro, Adauto S., Santiago, Gilvandete Mariapinheiro, Costa, Cinara Oliveira D´souza, Soares, Milena Botelho Pereira, Bezerra, Daniel Pereira, Shanmugam, Saravanan, Freitas, Lisiane dos S., Alves, Pericles Barreto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/34722
Acceso en línea:https://arca.fiocruz.br/handle/icict/34722
Access Level:acceso abierto
Palabra clave:Piper
Aedes aegypti
Citotoxicidade
Óleo essencial
Larvicida
Cytotoxicity
Essential oil
Larvicidal
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repository_id_str
dc.title.none.fl_str_mv Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
title Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
spellingShingle Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
Lima, Rafaely Nascimento
Piper
Aedes aegypti
Citotoxicidade
Óleo essencial
Larvicida
Piper
Aedes aegypti
Cytotoxicity
Essential oil
Larvicidal
title_short Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
title_full Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
title_fullStr Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
title_full_unstemmed Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
title_sort Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
dc.creator.none.fl_str_mv Lima, Rafaely Nascimento
Ribeiro, Adauto S.
Santiago, Gilvandete Mariapinheiro
Costa, Cinara Oliveira D´souza
Soares, Milena Botelho Pereira
Bezerra, Daniel Pereira
Shanmugam, Saravanan
Freitas, Lisiane dos S.
Alves, Pericles Barreto
author Lima, Rafaely Nascimento
author_facet Lima, Rafaely Nascimento
Ribeiro, Adauto S.
Santiago, Gilvandete Mariapinheiro
Costa, Cinara Oliveira D´souza
Soares, Milena Botelho Pereira
Bezerra, Daniel Pereira
Shanmugam, Saravanan
Freitas, Lisiane dos S.
Alves, Pericles Barreto
author_role author
author2 Ribeiro, Adauto S.
Santiago, Gilvandete Mariapinheiro
Costa, Cinara Oliveira D´souza
Soares, Milena Botelho Pereira
Bezerra, Daniel Pereira
Shanmugam, Saravanan
Freitas, Lisiane dos S.
Alves, Pericles Barreto
author2_role author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv Piper
Aedes aegypti
Citotoxicidade
Óleo essencial
Larvicida
topic Piper
Aedes aegypti
Citotoxicidade
Óleo essencial
Larvicida
Piper
Aedes aegypti
Cytotoxicity
Essential oil
Larvicidal
dc.subject.en.none.fl_str_mv Piper
Aedes aegypti
Cytotoxicity
Essential oil
Larvicidal
description CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), project PROMOB-Fapitec/CApES) and UFS.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-12T13:11:50Z
dc.date.available.fl_str_mv 2019-08-12T13:11:50Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Rafaely Nascimento et al. Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum. Natural Product Communications, p. 1-6, July 2019.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/34722
dc.identifier.issn.none.fl_str_mv 1934-578X
dc.identifier.doi.none.fl_str_mv 10.1177/1934578X19863932
identifier_str_mv LIMA, Rafaely Nascimento et al. Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum. Natural Product Communications, p. 1-6, July 2019.
1934-578X
10.1177/1934578X19863932
url https://arca.fiocruz.br/handle/icict/34722
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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spelling 2019-08-12T13:11:50Z2019-08-12T13:11:50Z2019LIMA, Rafaely Nascimento et al. Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum. Natural Product Communications, p. 1-6, July 2019.1934-578Xhttps://arca.fiocruz.br/handle/icict/3472210.1177/1934578X19863932CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), project PROMOB-Fapitec/CApES) and UFS.Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Biologia. São Cristovão, SE, Brasil / Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza, CE, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil / Universidade Federal de Sergipe. Departamento de Farmácia. São Cristóvão, SE, Brasil.Universidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, Brasil.The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were (E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 μg/mL), human promyelocytic leukemia (33.8 μg/mL), and murine melanoma (37.9 μg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC50 value of 122.4 μg/mL.engSAGE PublicationsPiperAedes aegyptiCitotoxicidadeÓleo essencialLarvicidaPiperAedes aegyptiCytotoxicityEssential oilLarvicidalAntitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLima, Rafaely NascimentoRibeiro, Adauto S.Santiago, Gilvandete MariapinheiroCosta, Cinara Oliveira D´souzaSoares, Milena Botelho PereiraBezerra, Daniel PereiraShanmugam, SaravananFreitas, Lisiane dos S.Alves, Pericles BarretoLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/c95cf878-3c67-4aa0-aa17-82d644285ec4/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALRafaely N. 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