Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis

The aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns. The electronic search was carried out in the electronic databases of Pubmed, ScienceDirect, Lila...

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Authors: Nímia, Heloisa Helena, Carvalho, Viviane Fernandes, Isaac, Cesar, Souza, Francisley Ávila [UNESP], Gemperli, Rolf, Paggiaro, André Oliveira
Format: article
Status:Published version
Publication Date:2018
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:English
OAI Identifier:oai:repositorio.unesp.br:11449/171102
Online Access:http://dx.doi.org/10.1016/j.burns.2018.05.014
http://hdl.handle.net/11449/171102
Access Level:Open access
Keyword:Burns
Infection
Occlusive dressings
Silver Sulfadiazine
Wound healing
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spelling Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysisBurnsInfectionOcclusive dressingsSilver SulfadiazineWound healingThe aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns. The electronic search was carried out in the electronic databases of Pubmed, ScienceDirect, Lilacs and BVS. The articles included were randomized clinical trials about burn treatment with SSD, which evaluated the healing and infection of burn wounds in humans. The exclusion criteria included articles, editorials and letters published in the form of abstracts, unpublished reports and case series, cross-sectional, observational experimental studies, and the use of sulfadiazine for other types of wounds. The search identified 873 references, and 24 studies were included in accordance with the eligibility criteria. The results showed a statistically favorable difference related to the time of healing for silver dressings (p < 0.0001; MD 3.83; 95% CI 2.03–5.62) and dressings without silver (p < 0.007; MD 2.9; 95% CI 0.81–5.00) in comparison with SSD. The rate of infection showed no difference in the group treated with SSD compared with the group treated with dressings containing silver (p > 0.05). The rate of infection was significantly higher in the SSD group compared with the group treated with dressings without silver (p < 0.005; MD 25.29% and MD 12.97%). Considering the clinical trials conducted up to the present time, the authors concluded that new dressings with and without silver show better results than SSD for wound healing, and burns treated with dressings without silver are less likely to become infected than burns with SSD. No differences between SSD and new silver materials were observed in relation to infection prevention.Guarulhos University Nursing Post Graduation Program, Praça Tereza Cristina, 88, CentroSão Paulo University Plastic Surgery Division, Av. Dr. Arnaldo, 455, Cerqueira CésarDentistry College UNESP, Rua José Bonifácio, 1193, AraçatubaDentistry College UNESP, Rua José Bonifácio, 1193, AraçatubaGraduation ProgramUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)2018-12-11T16:53:54Z2018-12-11T16:53:54Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1016/j.burns.2018.05.014Burns.1879-14090305-4179http://hdl.handle.net/11449/17110210.1016/j.burns.2018.05.0142-s2.0-850484695872-s2.0-85048469587.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBurns1,044info:eu-repo/semantics/openAccessNímia, Heloisa HelenaCarvalho, Viviane FernandesIsaac, CesarSouza, Francisley Ávila [UNESP]Gemperli, RolfPaggiaro, André Oliveira2025-09-11T05:00:48Zoai:repositorio.unesp.br:11449/171102Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-09-11T05:00:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
title Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
spellingShingle Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
Nímia, Heloisa Helena
Burns
Infection
Occlusive dressings
Silver Sulfadiazine
Wound healing
title_short Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
title_full Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
title_fullStr Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
title_full_unstemmed Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
title_sort Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Nímia, Heloisa Helena
Carvalho, Viviane Fernandes
Isaac, Cesar
Souza, Francisley Ávila [UNESP]
Gemperli, Rolf
Paggiaro, André Oliveira
author Nímia, Heloisa Helena
author_facet Nímia, Heloisa Helena
Carvalho, Viviane Fernandes
Isaac, Cesar
Souza, Francisley Ávila [UNESP]
Gemperli, Rolf
Paggiaro, André Oliveira
author_role author
author2 Carvalho, Viviane Fernandes
Isaac, Cesar
Souza, Francisley Ávila [UNESP]
Gemperli, Rolf
Paggiaro, André Oliveira
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Graduation Program
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Burns
Infection
Occlusive dressings
Silver Sulfadiazine
Wound healing
topic Burns
Infection
Occlusive dressings
Silver Sulfadiazine
Wound healing
description The aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns. The electronic search was carried out in the electronic databases of Pubmed, ScienceDirect, Lilacs and BVS. The articles included were randomized clinical trials about burn treatment with SSD, which evaluated the healing and infection of burn wounds in humans. The exclusion criteria included articles, editorials and letters published in the form of abstracts, unpublished reports and case series, cross-sectional, observational experimental studies, and the use of sulfadiazine for other types of wounds. The search identified 873 references, and 24 studies were included in accordance with the eligibility criteria. The results showed a statistically favorable difference related to the time of healing for silver dressings (p < 0.0001; MD 3.83; 95% CI 2.03–5.62) and dressings without silver (p < 0.007; MD 2.9; 95% CI 0.81–5.00) in comparison with SSD. The rate of infection showed no difference in the group treated with SSD compared with the group treated with dressings containing silver (p > 0.05). The rate of infection was significantly higher in the SSD group compared with the group treated with dressings without silver (p < 0.005; MD 25.29% and MD 12.97%). Considering the clinical trials conducted up to the present time, the authors concluded that new dressings with and without silver show better results than SSD for wound healing, and burns treated with dressings without silver are less likely to become infected than burns with SSD. No differences between SSD and new silver materials were observed in relation to infection prevention.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T16:53:54Z
2018-12-11T16:53:54Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.burns.2018.05.014
Burns.
1879-1409
0305-4179
http://hdl.handle.net/11449/171102
10.1016/j.burns.2018.05.014
2-s2.0-85048469587
2-s2.0-85048469587.pdf
url http://dx.doi.org/10.1016/j.burns.2018.05.014
http://hdl.handle.net/11449/171102
identifier_str_mv Burns.
1879-1409
0305-4179
10.1016/j.burns.2018.05.014
2-s2.0-85048469587
2-s2.0-85048469587.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Burns
1,044
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853672281671204864
score 15,198674

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