In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare

Previous studies had demonstrated that alginates from Sargassum sp. (Phaeophyta) showed a considerable activity against various murine tumors. The aim present study is to investigate the in vivo antitumor activity of two alginates (SVHV and SVLV) with di V erent viscosity extracted from brown seawee...

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Detalles Bibliográficos
Autores: Sousa, Alessandra Paula Alves de, Torres, Márcia Rocha, Pessoa, Cláudia, Moraes Filho, Manoel Odorico de, Rocha Filho, Francisco Dário, Alves, Ana Paula Negreiros Nunes, Costa-Lotufo, Letícia Veras
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:Brasil
Institución:Universidade Federal do Ceará (UFC)
Repositorio:Repositório Institucional da Universidade Federal do Ceará (UFC)
Idioma:inglés
OAI Identifier:oai:repositorio.ufc.br:riufc/5608
Acceso en línea:http://www.repositorio.ufc.br/handle/riufc/5608
Access Level:acceso abierto
Palabra clave:Sarcoma 180
Feófitas
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dc.title.pt_BR.fl_str_mv In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
title In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
spellingShingle In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
Sousa, Alessandra Paula Alves de
Sarcoma 180
Feófitas
title_short In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
title_full In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
title_fullStr In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
title_full_unstemmed In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
title_sort In vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgare
dc.creator.none.fl_str_mv Sousa, Alessandra Paula Alves de
Torres, Márcia Rocha
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Rocha Filho, Francisco Dário
Alves, Ana Paula Negreiros Nunes
Costa-Lotufo, Letícia Veras
author Sousa, Alessandra Paula Alves de
author_facet Sousa, Alessandra Paula Alves de
Torres, Márcia Rocha
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Rocha Filho, Francisco Dário
Alves, Ana Paula Negreiros Nunes
Costa-Lotufo, Letícia Veras
author_role author
author2 Torres, Márcia Rocha
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Rocha Filho, Francisco Dário
Alves, Ana Paula Negreiros Nunes
Costa-Lotufo, Letícia Veras
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Sarcoma 180
Feófitas
topic Sarcoma 180
Feófitas
description Previous studies had demonstrated that alginates from Sargassum sp. (Phaeophyta) showed a considerable activity against various murine tumors. The aim present study is to investigate the in vivo antitumor activity of two alginates (SVHV and SVLV) with di V erent viscosity extracted from brown seaweed Sargassum vulgare C. Agardh against Sarcoma 180 cells transplanted in mice. Both alginates inhibited growth of sarcoma 180. The oral route of administration was more e V ective for both alginates, leading to an inhibition of 51.8 and 74.8% for SVLV at the doses of 50 and 100 mg/m 2 /day, respectively, and of 66.2 and 88.8% for SVHV at the same doses. SVLV was 2.04 times more active after oral administration, while SVHV was 1.89, both at the dose of 100 mg/m 2 /day. Alginates-antitumor activity was related to the tumor proliferation rate inhibition, as observed by reduction of Ki67 staining in tumor of the treated-anima ls. The his- topathological analysis of liver and kidney showed that both organs were a V ected by SVHV and SVLV treatment. However, only SVLV led to acute tubular necrosis. Alginates cause the enlargement of the white pulp of the spleen of treated animals, suggesting t hat the observed antitumor activity could be related to alginates immunomodulatory properties.
publishDate 2007
dc.date.issued.fl_str_mv 2007-05
dc.date.accessioned.fl_str_mv 2013-08-13T12:44:46Z
dc.date.available.fl_str_mv 2013-08-13T12:44:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUSA, A. P. A. de et al. In vivo growth-ingrowth-inhibition of Sarcoma 180 tumor by alginates from brown seaweed Sargassum vulgare. Carbohydrate Polymers, Barking, Inglaterra, v.69, n. 1, p. 7-13, maio, 2007.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufc.br/handle/riufc/5608
dc.identifier.issn.none.fl_str_mv 0144-8617
identifier_str_mv SOUSA, A. P. A. de et al. In vivo growth-ingrowth-inhibition of Sarcoma 180 tumor by alginates from brown seaweed Sargassum vulgare. Carbohydrate Polymers, Barking, Inglaterra, v.69, n. 1, p. 7-13, maio, 2007.
0144-8617
url http://www.repositorio.ufc.br/handle/riufc/5608
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Carbohydrate Polymers
publisher.none.fl_str_mv Carbohydrate Polymers
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
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institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
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spelling 2013-08-13T12:44:46Z2013-08-13T12:44:46Z2007-05SOUSA, A. P. A. de et al. In vivo growth-ingrowth-inhibition of Sarcoma 180 tumor by alginates from brown seaweed Sargassum vulgare. Carbohydrate Polymers, Barking, Inglaterra, v.69, n. 1, p. 7-13, maio, 2007.0144-8617http://www.repositorio.ufc.br/handle/riufc/5608Previous studies had demonstrated that alginates from Sargassum sp. (Phaeophyta) showed a considerable activity against various murine tumors. The aim present study is to investigate the in vivo antitumor activity of two alginates (SVHV and SVLV) with di V erent viscosity extracted from brown seaweed Sargassum vulgare C. Agardh against Sarcoma 180 cells transplanted in mice. Both alginates inhibited growth of sarcoma 180. The oral route of administration was more e V ective for both alginates, leading to an inhibition of 51.8 and 74.8% for SVLV at the doses of 50 and 100 mg/m 2 /day, respectively, and of 66.2 and 88.8% for SVHV at the same doses. SVLV was 2.04 times more active after oral administration, while SVHV was 1.89, both at the dose of 100 mg/m 2 /day. Alginates-antitumor activity was related to the tumor proliferation rate inhibition, as observed by reduction of Ki67 staining in tumor of the treated-anima ls. The his- topathological analysis of liver and kidney showed that both organs were a V ected by SVHV and SVLV treatment. However, only SVLV led to acute tubular necrosis. Alginates cause the enlargement of the white pulp of the spleen of treated animals, suggesting t hat the observed antitumor activity could be related to alginates immunomodulatory properties.Carbohydrate PolymersSarcoma 180FeófitasIn vivo growth-inhibition of Sarc oma 180 tumor by alginates from brown seaweed Sargassum vulgareinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccessSousa, Alessandra Paula Alves deTorres, Márcia RochaPessoa, CláudiaMoraes Filho, Manoel Odorico deRocha Filho, Francisco DárioAlves, Ana Paula Negreiros NunesCosta-Lotufo, Letícia VerasLICENSElicense.txtlicense.txttext/plain; charset=utf-81786http://repositorio.ufc.br/bitstream/riufc/5608/2/license.txt8c4401d3d14722a7ca2d07c782a1aab3MD52ORIGINAL2007_art_apasousa1.pdf2007_art_apasousa1.pdfapplication/pdf810532http://repositorio.ufc.br/bitstream/riufc/5608/1/2007_art_apasousa1.pdf9e1fe5b6357bb491c2555647cf807ee1MD51riufc/56082019-11-10 18:37:53.669oai:repositorio.ufc.br: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Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2019-11-10T21:37:53Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
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