Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines

3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good y...

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Detalles Bibliográficos
Autores: dos Santos, Eric F. S., Cury, Nathalia M., do Nascimento, Tainara A., Raminelli, Cristiano [UNIFESP], Casagrande, Gleison A., Pereira, Claudio M. P., Simionatto, Euclesio, Yunes, Jose A., Pizzuti, Lucas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/55181
Acceso en línea:http://dx.doi.org/10.5935/0103-5053.20160166
https://repositorio.unifesp.br/handle/11600/55181
Access Level:acceso abierto
Palabra clave:amidinopyrazole
pyrazoline
cytotoxic activity
leukemia
ultrasonic irradiation
Descripción
Sumario:3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4

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