Does plasma ANP participate in natriuresis induced by a-MSH?
-Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant in...
| Authors: | , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 1997 |
| Country: | Brasil |
| Institution: | Universidade Federal do Pará (UFPA) |
| Repository: | Repositório Institucional da UFPA |
| Language: | English |
| OAI Identifier: | oai:repositorio.ufpa.br:2011/3290 |
| Online Access: | http://repositorio.ufpa.br/jspui/handle/2011/3290 |
| Access Level: | Open access |
| Keyword: | Hormônio estimulador de melanócito Fator natriurético atrial Natriurese Caliureses Diurelis |
| Summary: | -Melanocyte-stimulating hormone (-MSH; 0.6 and 3 nmol) microinjected into the anteroventral region of the third ventricle (AV3V) induced a significant increase in diuresis without modifying natriuresis or kaliuresis. Intraperitoneal (ip) injection of -MSH (3 and 9.6 nmol) induced a significant increase in urinary sodium, potassium and water excretion. Intraperitoneal (3 and 4.8 nmol) or iv (3 and 9.6 nmol) administration of -MSH did not induce any significant changes in plasma atrial natriuretic peptide (ANP), suggesting that the natriuresis, kaliuresis and diuresis induced by the systemic action of -MSH can be dissociated from the increase in plasma ANP. These preliminary results suggest that -MSH may be involved in a -MSHindependent mechanism of regulation of hydromineral metabolism. |
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