Short time L-glutamine supplementation of malnourished rats
ObjectiveConsidering that in malnourished patients supplemented with L-glutamine the negativity of the nitrogen balance tends to decrease, the present study aimed to determine whether malnourished Wistar rats supplemented with L-glutamine would show lower urinary nitrogen excretion, a greater deposi...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Brasil |
| Institución: | Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
| Repositorio: | Revista de Nutrição |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.periodicos.puc-campinas.edu.br:article/9986 |
| Acceso en línea: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/9986 |
| Access Level: | acceso abierto |
| Palabra clave: | amino acids dietary supplements glutamine malnutrition nitrogen rats aminoácidos suplementos dietéticos glutamina desnutrição nitrogênio ratos |
| Sumario: | ObjectiveConsidering that in malnourished patients supplemented with L-glutamine the negativity of the nitrogen balance tends to decrease, the present study aimed to determine whether malnourished Wistar rats supplemented with L-glutamine would show lower urinary nitrogen excretion, a greater deposition of nitrogen content in different tissues, and/or an alteration in the plasma amino acid levels.MethodsThe rats were divided into groups: 1) protein-energy malnutrition, 2) protein malnutrition and 3) normally nourished group. The urinary and tissue nitrogen contents were determined by the Kjeldahl method and plasma amino acids by liquid chromatography.ResultsWeight, urinary and tissue nitrogen accumulation were significantly reduced in the group with protein-energy malnutrition, but did not improve with L-glutamine supplementation supplied for a short time. The plasma amino acid concentrations showed no special pattern with L-glutamine supplementation.ConclusionIt was concluded that it was not possible to detect any positive effect of L-glutamine supplementation on the tissue and urinary nitrogen metabolism in malnourished rats. |
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