Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais

Background and Objectives - Bupivacaine has been a very useful local anesthetic in Obstetrics in spite of its potential cardiotoxicity. In obstetric analgesia, ropivacaine is preferred to bupivacaine, and levobupivacaine is less cardiotoxic than the racemic mixture. The aim of this study was to comp...

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Authors: Nakamura, G. [UNESP], Castiglia, Yara Marcondes Machado [UNESP], Do Nascimento, P. [UNESP], Rugollo, L. M S S [UNESP]
Format: article
Status:Published version
Publication Date:2000
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:Portuguese
OAI Identifier:oai:repositorio.unesp.br:11449/66073
Online Access:http://www.sba.com.br/arquivos/revista/rba/mar00105.pdf
http://hdl.handle.net/11449/66073
Access Level:Open access
Keyword:Analgesia: Labor
Anesthethic techniques, regional: Epidural
Anesthetics, Local: Bupivacaine, levobupicacaine, ropivacaine
bupivacaine
levobupivacaine
ropivacaine
adult
anesthesia induction
anesthesia level
anesthetic recovery
Apgar score
clinical article
drug effect
epidural anesthesia
female
human
neuromuscular blocking
obstetric analgesia
obstetric anesthesia
pain assessment
id BR_a50d9a3bff9bfee325dd856e2dcba4e6
oai_identifier_str oai:repositorio.unesp.br:11449/66073
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-FetaisBupivacaine, ropivacaine and levobupivacaine in extradural analgesia and labor anesthesia. Maternal-fetal effectsAnalgesia: LaborAnesthethic techniques, regional: EpiduralAnesthetics, Local: Bupivacaine, levobupicacaine, ropivacainebupivacainelevobupivacaineropivacaineadultanesthesia inductionanesthesia levelanesthetic recoveryApgar scoreclinical articledrug effectepidural anesthesiafemalehumanneuromuscular blockingobstetric analgesiaobstetric anesthesiapain assessmentBackground and Objectives - Bupivacaine has been a very useful local anesthetic in Obstetrics in spite of its potential cardiotoxicity. In obstetric analgesia, ropivacaine is preferred to bupivacaine, and levobupivacaine is less cardiotoxic than the racemic mixture. The aim of this study was to compare the maternal-fetal effects of bupivacaine, ropivacaine and levobupivacaine in obstetric analgesia and anesthesia. Methods - Participated in this study 33 term pregnant women, physical status ASA I and II submitted to epidural anesthesia who received 18.75 mg (in 15 ml completed with 9% saline) of: GI - bupivacaine, GII - ropivacaine, and GIII - levobupivacaine. Pain intensity, sensory block level, onset time, quality of analgesia, motor block intensity, analgesia duration and time for labor resolution were evaluated. For vaginal delivery, 40 mg (in 8 ml of saline) of the same local anesthetic were used; for cesarean delivery, the dose has been mg in 20 ml solution. Newborns of these mothers were evaluated through the Apgar score in minutes 1, 5 and 10, and through the Amiel-Tison method (neurologic and adaptative capacity score - NACS) at 30 min, 2 h, and 24 h. Results - There were no significant statistical differences among groups as to sensory block level, onset time, quality of analgesia, labor analgesia duration, time for labor resolution, and Apgar scores at minute 1. Ast to motor block, GIII > GII and GI was intermediary. In relation to pain intensity, there was a trend for GI > GIII. For Apgar scores in minute 5, GII > (GI = GIII), and in minute 10 (GI = GII) < GIII. NACS at 2 h showed, GII > GI > GIII, and at 24 h, GII > GIII > GI. Conclusions - Ropivacaine has relieved maternal pain with less motor block. Newborns of GII mothers (ropivacaine) showed the best Apgar and NACS scores.Depto. de Anestesiologia FMB - UNESP, 18618-970 Botucatu, SPDepto. de Anestesiologia FMB - UNESP, 18618-970 Botucatu, SPUniversidade Estadual Paulista (Unesp)2014-05-27T11:19:52Z2014-05-27T11:19:52Z2000-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article105-111application/pdfhttp://www.sba.com.br/arquivos/revista/rba/mar00105.pdfRevista Brasileira de Anestesiologia, v. 50, n. 2, p. 105-111, 2000.0034-7094http://hdl.handle.net/11449/660732-s2.0-00341224592-s2.0-0034122459.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Anestesiologia0.8500,320info:eu-repo/semantics/openAccessNakamura, G. [UNESP]Castiglia, Yara Marcondes Machado [UNESP]Do Nascimento, P. [UNESP]Rugollo, L. M S S [UNESP]2025-10-16T05:07:48Zoai:repositorio.unesp.br:11449/66073Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-16T05:07:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
Bupivacaine, ropivacaine and levobupivacaine in extradural analgesia and labor anesthesia. Maternal-fetal effects
title Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
spellingShingle Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
Nakamura, G. [UNESP]
Analgesia: Labor
Anesthethic techniques, regional: Epidural
Anesthetics, Local: Bupivacaine, levobupicacaine, ropivacaine
bupivacaine
levobupivacaine
ropivacaine
adult
anesthesia induction
anesthesia level
anesthetic recovery
Apgar score
clinical article
drug effect
epidural anesthesia
female
human
neuromuscular blocking
obstetric analgesia
obstetric anesthesia
pain assessment
title_short Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
title_full Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
title_fullStr Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
title_full_unstemmed Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
title_sort Bupivacaína, Ropivacaína e Levobupivacaína em Analgesia e Anestesia de Parto. Repercussões Materno-Fetais
dc.creator.none.fl_str_mv Nakamura, G. [UNESP]
Castiglia, Yara Marcondes Machado [UNESP]
Do Nascimento, P. [UNESP]
Rugollo, L. M S S [UNESP]
author Nakamura, G. [UNESP]
author_facet Nakamura, G. [UNESP]
Castiglia, Yara Marcondes Machado [UNESP]
Do Nascimento, P. [UNESP]
Rugollo, L. M S S [UNESP]
author_role author
author2 Castiglia, Yara Marcondes Machado [UNESP]
Do Nascimento, P. [UNESP]
Rugollo, L. M S S [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.subject.por.fl_str_mv Analgesia: Labor
Anesthethic techniques, regional: Epidural
Anesthetics, Local: Bupivacaine, levobupicacaine, ropivacaine
bupivacaine
levobupivacaine
ropivacaine
adult
anesthesia induction
anesthesia level
anesthetic recovery
Apgar score
clinical article
drug effect
epidural anesthesia
female
human
neuromuscular blocking
obstetric analgesia
obstetric anesthesia
pain assessment
topic Analgesia: Labor
Anesthethic techniques, regional: Epidural
Anesthetics, Local: Bupivacaine, levobupicacaine, ropivacaine
bupivacaine
levobupivacaine
ropivacaine
adult
anesthesia induction
anesthesia level
anesthetic recovery
Apgar score
clinical article
drug effect
epidural anesthesia
female
human
neuromuscular blocking
obstetric analgesia
obstetric anesthesia
pain assessment
description Background and Objectives - Bupivacaine has been a very useful local anesthetic in Obstetrics in spite of its potential cardiotoxicity. In obstetric analgesia, ropivacaine is preferred to bupivacaine, and levobupivacaine is less cardiotoxic than the racemic mixture. The aim of this study was to compare the maternal-fetal effects of bupivacaine, ropivacaine and levobupivacaine in obstetric analgesia and anesthesia. Methods - Participated in this study 33 term pregnant women, physical status ASA I and II submitted to epidural anesthesia who received 18.75 mg (in 15 ml completed with 9% saline) of: GI - bupivacaine, GII - ropivacaine, and GIII - levobupivacaine. Pain intensity, sensory block level, onset time, quality of analgesia, motor block intensity, analgesia duration and time for labor resolution were evaluated. For vaginal delivery, 40 mg (in 8 ml of saline) of the same local anesthetic were used; for cesarean delivery, the dose has been mg in 20 ml solution. Newborns of these mothers were evaluated through the Apgar score in minutes 1, 5 and 10, and through the Amiel-Tison method (neurologic and adaptative capacity score - NACS) at 30 min, 2 h, and 24 h. Results - There were no significant statistical differences among groups as to sensory block level, onset time, quality of analgesia, labor analgesia duration, time for labor resolution, and Apgar scores at minute 1. Ast to motor block, GIII > GII and GI was intermediary. In relation to pain intensity, there was a trend for GI > GIII. For Apgar scores in minute 5, GII > (GI = GIII), and in minute 10 (GI = GII) < GIII. NACS at 2 h showed, GII > GI > GIII, and at 24 h, GII > GIII > GI. Conclusions - Ropivacaine has relieved maternal pain with less motor block. Newborns of GII mothers (ropivacaine) showed the best Apgar and NACS scores.
publishDate 2000
dc.date.none.fl_str_mv 2000-01-01
2014-05-27T11:19:52Z
2014-05-27T11:19:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.sba.com.br/arquivos/revista/rba/mar00105.pdf
Revista Brasileira de Anestesiologia, v. 50, n. 2, p. 105-111, 2000.
0034-7094
http://hdl.handle.net/11449/66073
2-s2.0-0034122459
2-s2.0-0034122459.pdf
url http://www.sba.com.br/arquivos/revista/rba/mar00105.pdf
http://hdl.handle.net/11449/66073
identifier_str_mv Revista Brasileira de Anestesiologia, v. 50, n. 2, p. 105-111, 2000.
0034-7094
2-s2.0-0034122459
2-s2.0-0034122459.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Anestesiologia
0.850
0,320
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 105-111
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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score 15,301629

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