Estudo fitoquímico de Croton grewioides Baill. e revisão da ocorrência das principais classes de metabólitos do gênero Croton
Euphorbiaceae is the sixth largest family of plants in the world and it is represented by 300 genera and approximately 7500 species. Among the many genus that composes this family, Croton stands as the second largest, with about 800 species, possessing a neotropical distribution. It is one of the ge...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | Brasil |
| Institución: | Universidade Federal da Paraíba (UFPB) |
| Repositorio: | Biblioteca Digital de Teses e Dissertações da UFPB |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufpb.br:tede/6782 |
| Acceso en línea: | https://repositorio.ufpb.br/jspui/handle/tede/6782 |
| Access Level: | acceso abierto |
| Palabra clave: | Croton grewioides Diterpenos A pineno Óleo essencial Modulação Bacteriana Diterpenes A pinene Essential oil Bacterial modulation CIENCIAS BIOLOGICAS::FARMACOLOGIA |
| Sumario: | Euphorbiaceae is the sixth largest family of plants in the world and it is represented by 300 genera and approximately 7500 species. Among the many genus that composes this family, Croton stands as the second largest, with about 800 species, possessing a neotropical distribution. It is one of the genus more studied, largely due to promising bioactive compounds produced by this group. To contribute to the chemotaxonomic study of family Euphorbiaceae and genus Croton, the extract of C. grewioides was subjected to a phytochemical study to isolate its chemical constituents, through usual chromatographic methods, and then to identify them by means of spectroscopic methods such as infrared, NMR1H and 13C and uni-dimensional, mass spectrometry, and comparison with literature data. The chemical study of aerial parts of C. grewioides resulted in the identification of thirteen compounds (ent-2-oxo-cleroda-3,13-dien-15α,16-olide-21-ate, ent-2-oxo-cleroda- 3,13-dien-15β,16-olide-21-ate, ent-15,16-epoxy-2-oxo-3,13(16),14-clerodatriene, ent-15,16- epoxy-20-acetoxy-2-oxo-3,13(16),14-clerodatriene, ent-15,16-epoxy-2-oxo-3,13(16),14- clerodatrien-20-oic acid, 2-oxo-5α,8α-cleroda-3,13-dien-15,16-olide, cleroda-3,13-dien- 15,16-olide-8-oic acid, ent-kaur-16-en-19-oic acid, ent-7α-acetoxytraquiloban-18-oic, octasyl trans-ferulate, 4-alyl-1,2-dimethoxybenzene, 2-hidroxy-4,6-dimethoxy-acetofenone e estigmast-4-en-3-one), and three first described in the literature, isolates the first time in gender and eight first reported in the species. The chemical composition of essential oil showed eighteen components, among which α-pinene (47.43%) showed up with major compound. Essential oil C. grewioides and α-pinene were tested for toxicity against Staphylococcus aureus SA-1199B and IS-58.The essential oil C. grewioides and α-pinene tested did not show any significant antibacterial activity against Staphylococcus aureus strains used, but were able to modulate the bacterial resistance to drugs. |
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