In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients

Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in...

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Autores: Marchetti, Desirèe Padilha, Donida, Bruna, Deon, Marion, Jacques, Carlos Eduardo Diaz, Jardim, Laura Bannach, Vargas, Carmen Regla
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/174872
Acceso en línea:http://hdl.handle.net/10183/174872
Access Level:acceso abierto
Palabra clave:N-Acetil-L-Cisteína
X- linked adrenoleukodystrophy
N-acetyl-L-cysteine
Glutathione
Sulfhydryl
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spelling 2018-04-20T02:30:29Z20172357-9730http://hdl.handle.net/10183/174872001065408Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated. Results: A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients. Conclusion: These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients.application/pdfengClinical and biomedical research. Porto Alegre, RS. Vol. 37, no. 1 (2017), p. 33-37N-Acetil-L-CisteínaX- linked adrenoleukodystrophyN-acetyl-L-cysteineGlutathioneSulfhydrylIn vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patientsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSMarchetti, Desirèe PadilhaDonida, BrunaDeon, MarionJacques, Carlos Eduardo DiazJardim, Laura BannachVargas, Carmen ReglaORIGINAL001065408.pdf001065408.pdfTexto completo (inglês)application/pdf1027211http://www.lume.ufrgs.br/bitstream/10183/174872/1/001065408.pdf66c01285cb07fa73bf0f8baac453cb82MD51TEXT001065408.pdf.txt001065408.pdf.txtExtracted Texttext/plain20404http://www.lume.ufrgs.br/bitstream/10183/174872/2/001065408.pdf.txteb38bbb45f01db4fe52d4ff49fbb29daMD5210183/1748722021-05-07 04:39:12.870555oai:www.lume.ufrgs.br:10183/174872Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2021-05-07T07:39:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
title In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
spellingShingle In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
Marchetti, Desirèe Padilha
N-Acetil-L-Cisteína
X- linked adrenoleukodystrophy
N-acetyl-L-cysteine
Glutathione
Sulfhydryl
title_short In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
title_full In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
title_fullStr In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
title_full_unstemmed In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
title_sort In vitro effect of N-acetyl-L-cysteine on glutathione and sulfhydryl levels in X-linked adrenoleukodystrophy patients
dc.creator.none.fl_str_mv Marchetti, Desirèe Padilha
Donida, Bruna
Deon, Marion
Jacques, Carlos Eduardo Diaz
Jardim, Laura Bannach
Vargas, Carmen Regla
author Marchetti, Desirèe Padilha
author_facet Marchetti, Desirèe Padilha
Donida, Bruna
Deon, Marion
Jacques, Carlos Eduardo Diaz
Jardim, Laura Bannach
Vargas, Carmen Regla
author_role author
author2 Donida, Bruna
Deon, Marion
Jacques, Carlos Eduardo Diaz
Jardim, Laura Bannach
Vargas, Carmen Regla
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv N-Acetil-L-Cisteína
topic N-Acetil-L-Cisteína
X- linked adrenoleukodystrophy
N-acetyl-L-cysteine
Glutathione
Sulfhydryl
dc.subject.eng.fl_str_mv X- linked adrenoleukodystrophy
N-acetyl-L-cysteine
Glutathione
Sulfhydryl
description Introduction: Recent evidence shows that oxidative stress seems to be related with the pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder. Methods: In the present study, the in vitro effect of N-acetyl-L-cysteine (NAC) on glutathione (GSH) and sulfhydryl levels in X-ALD patients was evaluated. Results: A significant reduction of GSH and sulfhydryl content was observed in X-ALD patients compared to the control group. Furthermore, 5 mM of NAC, in vitro, led to an increase in GSH content and sulfhydryl groups in these patients. Conclusion: These data probably indicate that an adjuvant therapy with the antioxidant NAC could improve the oxidative imbalance in X-ALD patients.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-20T02:30:29Z
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dc.identifier.issn.pt_BR.fl_str_mv 2357-9730
dc.identifier.nrb.pt_BR.fl_str_mv 001065408
identifier_str_mv 2357-9730
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Porto Alegre, RS. Vol. 37, no. 1 (2017), p. 33-37
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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