Humoral immune response to Mycobacterium tuberculosis rGroES antigen in patients with tuberculosis and their household contacts
Tuberculosis (TB) remains one of the most important public health problems ofthe world, with 8-10 million new cases and 2-3 million deaths each year. About 50million people are infected with Mycobacterium tuberculosis. In order to developimmunodiagnostic tests for TB, several antigens have been test...
| Authors: | , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2011 |
| Country: | Brasil |
| Institution: | Universidade Federal de Goiás (UFG) |
| Repository: | Revista de patologia tropical (Online) |
| Language: | Portuguese |
| OAI Identifier: | oai:ojs.revistas.ufg.br:article/13915 |
| Online Access: | https://revistas.ufg.br/iptsp/article/view/13915 |
| Access Level: | Open access |
| Keyword: | Mycobacterium tuberculosis MtGroEs ELISA IgG and IgM Patients with Tuberculosis Household contacts. GroEs Anticorpos IgG e IgM Pacientes Contatos. |
| Summary: | Tuberculosis (TB) remains one of the most important public health problems ofthe world, with 8-10 million new cases and 2-3 million deaths each year. About 50million people are infected with Mycobacterium tuberculosis. In order to developimmunodiagnostic tests for TB, several antigens have been tested for the humoralimmune response of patients with active TB. ELISA was performed with plasmasamples from 45 patients with pulmonary TB and 172 contacts (96 negative and 76positive for the tuberculin skin test). The humoral immune response was evaluated through assessment of IgM and IgG antibodies against recombinant Mycobacteriumtuberculosis GroES (MtGroEs). Patients with active pulmonary tuberculosis hadhigher levels of IgG anti-rGroEs than healthy individuals, allowing discriminationbetween the two groups. |
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