Polymorphism of the codante region of the NOS3 gene in the elderly with Metabolic Syndrome

Objective: The present study analyzed whether the presence of VNTR polymorphism located in intron 4 of the NOS3 gene in the codante region differs in patients with Metabolic Syndrome and patients with Hypertension and/or Diabetes Mellitus from normotensive controls. Method: In this case-control stud...

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Detalles Bibliográficos
Autores: Silva, Izabel Cristina Rodrigues da, Possatti, Isabella, Garcia, Camila Magalhães, Paula, Giovanna Rodrigues de, Teixeira, Marcela dos Santos, Gontijo, Bruna Rodrigues, Duarte6, Ligia Canongia de Abreu Cardoso, Funghetto, Silvana Schwerz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Institución:Faculdade Evangélica de Valparaíso (Facev)
Repositorio:REVISA : Revista de Divulgação Científica Sena Aires (Online)
Idioma:portugués
inglés
OAI Identifier:oai:ojs.rdcsa.emnuvens.com.br:article/221
Acceso en línea:https://rdcsa.emnuvens.com.br/revista/article/view/221
Access Level:acceso abierto
Palabra clave:Síndrome Metabólica
Diabetes Mellitus
Hipertensão Arterial Sistêmica
Metabolic Syndrome
Systemic Arterial Hypertension
NOS3;
Genetic polymorphism
Descripción
Sumario:Objective: The present study analyzed whether the presence of VNTR polymorphism located in intron 4 of the NOS3 gene in the codante region differs in patients with Metabolic Syndrome and patients with Hypertension and/or Diabetes Mellitus from normotensive controls. Method: In this case-control study, the PCR technique was performed to identify the presence of genotypes in 94 elderly patients living in the Federal District. Associations with clinical manifestations were made in the SPSS program. The probability of Hardy-Weinberg equilibrium and Odds Ratio was analyzed, considering a confidence interval of 95% and significance level of 5%. Results: we found that of the 94 patients, 71 showed the presence of hypertension and 23 the absence of the disease, the p-value obtained was 0.218. Regarding Diabetes Mellitus, 49 old women have the problem and 45 do not have the p value obtained was 0.372. Conclusion: There is no association between nos3 gene polymorphism genotypes, and the manifestation of Arterial Hypertension and Diabetes Mellitus in elderly patients with MS.

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