17DD Yellow Fever revaccination and heightened long-term immunity in populations of disease-endemic areas, Brazil

We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine–specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the lev...

Descripción completa

Detalles Bibliográficos
Autores: Azevedo, Ana Carolina Campi, Magalhães, Vanessa Peruhype, Reis, Jordana Grazziela Coelho dos, Antonelli, Lis Ribeiro do Valle, Pereira, Christiane Costa, Speziali, Eliane, Reis, Laise Rodrigues, Lemos, Jandira Aparecida, Ribeiro, José Geraldo Leite, Camacho, Luiz Antônio Bastos, Maia, Maria de Lourdes de Sousa, Lima, Sheila Maria Barbosa de, Simões, Marisol, Martins, Reinaldo de Menezes, Homma, Akira, Malaquias, Luiz Cosme Cota, Tauil, Pedro Luiz, Vasconcelos, Pedro Fernando da Costa, Romano, Alessandro Pecego Martins, Domingues, Carla Magda, Carvalho, Andréa Teixeira, Martins Filho, Olindo Assis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Institución:Instituto Evandro Chagas (IEC)
Repositorio:Repositório Digital do Instituto Evandro Chagas (Patuá)
Idioma:inglés
OAI Identifier:oai:patua.iec.gov.br:iec/3828
Acceso en línea:https://patua.iec.gov.br/handle/iec/3828
Access Level:acceso abierto
Palabra clave:Febre Amarela / imunologia
Vacina contra Febre Amarela / imunologia
Imunização Secundária
Descripción
Sumario:We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine–specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF–specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.

Similares en LA Referencia