Evaluation of the anti-Inflammatory and antinociceptive effects of the essential oil from leaves of Xylopia laevigata in experimental models

Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of y-...

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Detalles Bibliográficos
Autores: Antoniolli, Ângelo Roberto, Queiroz, João Carlos C., Quintans-Júnior, Lucindo José, Brito, Renan Guedes de, Barreto, Rosana de Souza Siqueira, Costa, Emmanoel Vilaça, Silva, Thanany Brasil da, Prata, Ana Paula do Nascimento, Lucca Júnior, Waldecy de, Almeida, Jackson Roberto Guedes da Silva, Lima, Julianeli Tolentino de, Quintans, Jullyana de Souza Siqueira
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Brasil
Institución:Universidade Federal de Sergipe (UFS)
Repositorio:Repositório Institucional da UFS
Idioma:inglés
OAI Identifier:oai:oai:ri.ufs.br:repo_01:riufs/1212
Acceso en línea:https://ri.ufs.br/handle/riufs/1212
Access Level:acceso abierto
Palabra clave:Xylopia laevigata (Annonaceae)
Atividade antinociceptiva
Anti-inflamatório
Descripción
Sumario:Xylopia laevigata (Annonaceae) is a medicinal plant used in folk medicine to treat pain and inflammation. Thus, we investigated the possible antioxidant, antinociceptive, and anti-inflammatory effects of X. laevigata leaf essential oil (EOX) in animal models. Our EOX sample showed the presence of y-muurolene (17.78%), o-cadinene (12.23%), bicyclogermacrene (7.77%), and a-copaene (7.17%) as main compounds. EOX presented a strong antioxidant potential according to the DPPH, TBARS, and nitrite production tests. Additionally, pretreatment with EOX, in mice, also significantly produced (p < 0.05 or p < 0.001) antinociceptive effect by reduction of nociceptive behavior (in formalin and writhing tests). The EOX showed c-Fos label in the olfactory bulb, piriform cortex, and periaqueductal gray. Acute administration of EOX exhibited a significant (p < 0.01 or p < 0.001) anti-inflammatory profile in the carrageenan-induced peritonitis and by the carrageenan-induced hindpaw edema tests in mice. Our results provide evidence for the use of X. laevigata by traditional medicine practitioners in the management of pain and inflammatory disorders.

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