Triagem de hemoglobinopatias em doadores de sangue de Caxias do Sul, Rio Grande do Sul, Brasil: prevalência em área de colonização italiana
The high prevalence of beta thalassemia among Italians and their participation in the ethnic formation of Caxias do Sul, Rio Grande do Sul State, Brazil, and neighboring cities prompted us to investigate hemoglobinopathies in 608 blood donors at the Caxias do Sul Regional Blood Center. Despite the e...
| Authors: | , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2004 |
| Country: | Brasil |
| Institution: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repository: | Cadernos de Saúde Pública |
| Language: | Portuguese |
| OAI Identifier: | oai:ojs.teste-cadernos.ensp.fiocruz.br:article/2304 |
| Online Access: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/2304 |
| Access Level: | Open access |
| Keyword: | Hemoglobinopatias Doadores de Sangue Eletroforese |
| Summary: | The high prevalence of beta thalassemia among Italians and their participation in the ethnic formation of Caxias do Sul, Rio Grande do Sul State, Brazil, and neighboring cities prompted us to investigate hemoglobinopathies in 608 blood donors at the Caxias do Sul Regional Blood Center. Despite the ethnic influence, abnormal hemoglobin levels were found in only 1.81% of the donors (0.16% Hb AC, 0.99% Hb AS, and 0.66% Hb AH), similar to the levels observed in a study on qualitative disorders conducted in the rural area of Rio Grande do Sul. In our setting, the most commonly used screening tests for thalassemia, combined with DNA sequencing, were unable to detect quantitative hemoglobin synthesis disorders. This may be attributable to still-unknown genetic disorders, technical limitations, or simply to miscegenation. |
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