Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes
The present work evaluated the pharmacokinetics and efficacy of the association of 15cmg/kg toltrazuril +5cmg/kg fenbendazole against Eimeria spp. and gastrointestinal nematodes (GINs) in calves of different regions of Brazil (Center-West, Southeast, and South). A total of seven experiments were car...
| Autores: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | Brasil |
| Recursos: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/298847 |
| Acesso em linha: | http://dx.doi.org/10.1016/j.vprsr.2023.100968 https://hdl.handle.net/11449/298847 |
| Access Level: | acceso abierto |
| Palavra-chave: | Benzimidazol Cooperia punctata Eimeria bovis Eimeria zuernii Haemonhcus placei Triazinetrione |
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Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodesBenzimidazolCooperia punctataEimeria bovisEimeria zuerniiHaemonhcus placeiTriazinetrioneThe present work evaluated the pharmacokinetics and efficacy of the association of 15cmg/kg toltrazuril +5cmg/kg fenbendazole against Eimeria spp. and gastrointestinal nematodes (GINs) in calves of different regions of Brazil (Center-West, Southeast, and South). A total of seven experiments were carried out, five of which determined formulation efficacy against Eimeria spp., considering the following aspects: therapeutic, preventive, metaphylactic, and residual efficacy. Therapeutic efficacy experiments for GINs were carried out by parasitological necropsy. The toltrazuril + fenbendazole association demonstrated ≥95% efficacy against Eimeria spp. for 21 days post-treatment (DPT). When used preventively and metaphylatically, the same association demonstrated ≥97% efficacy against E. zuernii, E. ellipsoidalis, E. cylindrica, E. bovis, E. wyomingensis and E. auburnensis. Toltrazuril + fenbendazole administered seven days before challenge was 100% effective against all these Eimeria species. Results of therapeutic, preventive, metaphylactic and residual efficacies can be related to the pharmacokinetic results, especially considering toltrazuril sulfone, which was detected in animal plasma for a longer period than the parent compound. Toltrazuril + fenbendazole achieved 100% anthelminthic efficacy against the GINs Haemonchus placei (L4), Cooperia pectinata and Oesophagostomum radiatum; 99.94% against adult H. placei; and 99.98% against C. puntacta. The association of toltrazuril + fenbendazole, associated with other measures, is an important and suitable tool for the control and treatment of Eimeria spp. and GINs in young cattle.Centro de Parasitologia Veterinária Escola de Veterinária e Zootecnia Universidade Federal de Goiás GoiâniaFaculdade de Ciências Agrárias e Veterinárias UNESP/CPPAR. JaboticabalDepartamento de Medicina Veterinária Preventiva Escola de Veterinária Universidade Federal de Minas Gerais, Minas GeraisMSD Animal HealthDepartamento de Saúde Coletiva Veterinária e Saúde Pública Faculdade de Medicina Veterinária Universidade Federal FluminenseUniversidade Brasil, DescalvadoFaculdade de Ciências Agrárias e Veterinárias UNESP/CPPAR. JaboticabalUniversidade Federal de Goiás (UFG)Universidade Estadual Paulista (UNESP)Universidade Federal de Minas Gerais (UFMG)MSD Animal HealthUniversidade Federal Fluminense (UFF)Universidade Brasil2025-04-29T18:38:18Z2024-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.vprsr.2023.100968Veterinary Parasitology: Regional Studies and Reports, v. 47.2405-9390https://hdl.handle.net/11449/29884710.1016/j.vprsr.2023.1009682-s2.0-85179963484Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Parasitology: Regional Studies and Reportsinfo:eu-repo/semantics/openAccessZapa, Dina Maria BeltránHeller, Luciana Maffinide Aquino, Lídia MendesCouto, Luiz Felipe MonteiroGomes, Lucas Vinicius Costa [UNESP]Ferreira, Lorena LopesVettorato, Luis FernandoBarufi, Franciscode Oliveira Arriero Amaral, HeitorChiummo, Rafael MarinSonada, Rafael Bazagliade Castro Rodrigues, DanielSakamoto, Claudio Alessandro M.Soares, Vando Edésioda Costa, Alvimar José [UNESP]Lopes, Welber Daniel Zanetti2025-10-22T10:17:49Zoai:repositorio.unesp.br:11449/298847Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-22T10:17:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| title |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| spellingShingle |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes Zapa, Dina Maria Beltrán Benzimidazol Cooperia punctata Eimeria bovis Eimeria zuernii Haemonhcus placei Triazinetrione |
| title_short |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| title_full |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| title_fullStr |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| title_full_unstemmed |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| title_sort |
Toltrazuril + fenbendazole for cattle: Pharmacokinetics and efficacy against Eimeria spp. and gastrointestinal nematodes |
| dc.creator.none.fl_str_mv |
Zapa, Dina Maria Beltrán Heller, Luciana Maffini de Aquino, Lídia Mendes Couto, Luiz Felipe Monteiro Gomes, Lucas Vinicius Costa [UNESP] Ferreira, Lorena Lopes Vettorato, Luis Fernando Barufi, Francisco de Oliveira Arriero Amaral, Heitor Chiummo, Rafael Marin Sonada, Rafael Bazaglia de Castro Rodrigues, Daniel Sakamoto, Claudio Alessandro M. Soares, Vando Edésio da Costa, Alvimar José [UNESP] Lopes, Welber Daniel Zanetti |
| author |
Zapa, Dina Maria Beltrán |
| author_facet |
Zapa, Dina Maria Beltrán Heller, Luciana Maffini de Aquino, Lídia Mendes Couto, Luiz Felipe Monteiro Gomes, Lucas Vinicius Costa [UNESP] Ferreira, Lorena Lopes Vettorato, Luis Fernando Barufi, Francisco de Oliveira Arriero Amaral, Heitor Chiummo, Rafael Marin Sonada, Rafael Bazaglia de Castro Rodrigues, Daniel Sakamoto, Claudio Alessandro M. Soares, Vando Edésio da Costa, Alvimar José [UNESP] Lopes, Welber Daniel Zanetti |
| author_role |
author |
| author2 |
Heller, Luciana Maffini de Aquino, Lídia Mendes Couto, Luiz Felipe Monteiro Gomes, Lucas Vinicius Costa [UNESP] Ferreira, Lorena Lopes Vettorato, Luis Fernando Barufi, Francisco de Oliveira Arriero Amaral, Heitor Chiummo, Rafael Marin Sonada, Rafael Bazaglia de Castro Rodrigues, Daniel Sakamoto, Claudio Alessandro M. Soares, Vando Edésio da Costa, Alvimar José [UNESP] Lopes, Welber Daniel Zanetti |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (UNESP) Universidade Federal de Minas Gerais (UFMG) MSD Animal Health Universidade Federal Fluminense (UFF) Universidade Brasil |
| dc.subject.por.fl_str_mv |
Benzimidazol Cooperia punctata Eimeria bovis Eimeria zuernii Haemonhcus placei Triazinetrione |
| topic |
Benzimidazol Cooperia punctata Eimeria bovis Eimeria zuernii Haemonhcus placei Triazinetrione |
| description |
The present work evaluated the pharmacokinetics and efficacy of the association of 15cmg/kg toltrazuril +5cmg/kg fenbendazole against Eimeria spp. and gastrointestinal nematodes (GINs) in calves of different regions of Brazil (Center-West, Southeast, and South). A total of seven experiments were carried out, five of which determined formulation efficacy against Eimeria spp., considering the following aspects: therapeutic, preventive, metaphylactic, and residual efficacy. Therapeutic efficacy experiments for GINs were carried out by parasitological necropsy. The toltrazuril + fenbendazole association demonstrated ≥95% efficacy against Eimeria spp. for 21 days post-treatment (DPT). When used preventively and metaphylatically, the same association demonstrated ≥97% efficacy against E. zuernii, E. ellipsoidalis, E. cylindrica, E. bovis, E. wyomingensis and E. auburnensis. Toltrazuril + fenbendazole administered seven days before challenge was 100% effective against all these Eimeria species. Results of therapeutic, preventive, metaphylactic and residual efficacies can be related to the pharmacokinetic results, especially considering toltrazuril sulfone, which was detected in animal plasma for a longer period than the parent compound. Toltrazuril + fenbendazole achieved 100% anthelminthic efficacy against the GINs Haemonchus placei (L4), Cooperia pectinata and Oesophagostomum radiatum; 99.94% against adult H. placei; and 99.98% against C. puntacta. The association of toltrazuril + fenbendazole, associated with other measures, is an important and suitable tool for the control and treatment of Eimeria spp. and GINs in young cattle. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-01-01 2025-04-29T18:38:18Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.vprsr.2023.100968 Veterinary Parasitology: Regional Studies and Reports, v. 47. 2405-9390 https://hdl.handle.net/11449/298847 10.1016/j.vprsr.2023.100968 2-s2.0-85179963484 |
| url |
http://dx.doi.org/10.1016/j.vprsr.2023.100968 https://hdl.handle.net/11449/298847 |
| identifier_str_mv |
Veterinary Parasitology: Regional Studies and Reports, v. 47. 2405-9390 10.1016/j.vprsr.2023.100968 2-s2.0-85179963484 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Veterinary Parasitology: Regional Studies and Reports |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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