Intermittent negative pressure ventilation may increase urine flow in normal subjects
In order to analyze the effect of intermittent negative pressure ventilation (NPV) on renal function, we studied 20 healthy male volunteers (mean age 29±4.1 years). NPV was performed with an Emerson Chest Respirator Pump, adjusted to a breathing frequency of 10 respirations per minute, with inspirat...
| Autores: | , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 1994 |
| País: | Brasil |
| Recursos: | Universidade Federal de São Paulo (UNIFESP) |
| Repositório: | Repositório Institucional da UNIFESP |
| Idioma: | inglês |
| OAI Identifier: | oai:repositorio.unifesp.br:11600/339 |
| Acesso em linha: | http://dx.doi.org/10.1590/S1516-31801994000200006 http://repositorio.unifesp.br/handle/11600/339 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Antidiuretic hormone (ADH) atrial natriuretic factor (ANF) negative pressure ventilation (NPV) positive end expiratory pressure (PEEP) |
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Intermittent negative pressure ventilation may increase urine flow in normal subjectsAntidiuretic hormone (ADH)atrial natriuretic factor (ANF)negative pressure ventilation (NPV)positive end expiratory pressure (PEEP)In order to analyze the effect of intermittent negative pressure ventilation (NPV) on renal function, we studied 20 healthy male volunteers (mean age 29±4.1 years). NPV was performed with an Emerson Chest Respirator Pump, adjusted to a breathing frequency of 10 respirations per minute, with inspiratory time/total respiratory time ratio of 0.4 and negative pressure of 25 cmH2O. The experimental protocol was carried out in two phases of two hours each - spontaneous breathing and NPV breathing. At the end of each phase, urine volume of the whole period was collected as well as venous blood sample for biochemical determinations. During NPV there was significant increase (P<0.05) in urine flow rate (1.43±0.81 to 2.76±1.95 ml/min) as well as in natriuresis (258±201 to 389±175 mcEq/min), kaliuresis (61±45 to 98±49 mcEq/min), fractional sodium excretion (1.38±0.88 to 1.96±0.98%), osmolar clearance (3.13±1.82 to 4.32±1.24 ml/min) and pH (7.37± 0.04 to 7.41±0.07) with unchanged creatinine and free water clearances. We concluded that NPV increases urine flow rate, kaliuresis and natriuresis but the data we have do not allow us to explain the mechanisms underlying such a phenomenon.Com o objetivo de avaliar o efeito da ventilação por pressão negativa intermitente (NPV) na função renal, estudamos vinte indivíduos voluntários normais (idade média de 29 ± 41 anos). A NPV foi obtida utilizando-se um respirador Emerson Chest Respirator Pump o qual foi ajustado para assegurar freqüência de 10 respirações por minuto com relação de tempo inspiratório e tempo respiratório total de 0,4 e pressão negativa de 25 cm de água. O protocolo experimental foi desenvolvido em 2 fases com duração de duas horas cada - fase de respiração espontânea e fase de respiração com NPV. No final de cada fase, foi medido o volume urinário e coletado sangue para as determinações bioquímicas. Durante a NPV houve um aumento significante do fluxo urinário (p<0,05) (1,42 ± 0,81 para 2,76 ± 1,95 ml/min), da natriurese (258 ± 201 para 389 ± 175 mcEq/min), da caliurese (61 ± 45 para 98 ± 49mcEq/min), da fração de excreção de sódio (1,38 ± 1,82 para 4,32 ± 1,24 ml/min) e do pH (7,37 ± 0,04 para 7,41 ± 0,07). Os clearances de creatinina e de água livre não se alteraram significativamente. Concluímos que a respiração com NPV aumenta o fluxo urinário, a caliurese e a natriurese, porém nossos dados não nos permite explicar a origem deste achados.Escola Paulista de Medicina Respiratory and Nephrology DivisionsUNIFESP, EPM, Respiratory and Nephrology DivisionsSciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:24:26Z2015-06-14T13:24:26Z1994-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion551-554application/pdfhttp://dx.doi.org/10.1590/S1516-31801994000200006São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 112, n. 2, p. 551-554, 1994.10.1590/S1516-31801994000200006S1516-31801994000200006.pdf1516-3180S1516-31801994000200006http://repositorio.unifesp.br/handle/11600/339ark:/48912/001300002qwg0engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPDias, Ricardo Marques [UNIFESP]Stabile, Carlos [UNIFESP]Dotto, Pedro [UNIFESP]Jardim, José Roberto [UNIFESP]2024-07-28T12:01:08Zoai:repositorio.unifesp.br:11600/339Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T12:01:08Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| title |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| spellingShingle |
Intermittent negative pressure ventilation may increase urine flow in normal subjects Dias, Ricardo Marques [UNIFESP] Antidiuretic hormone (ADH) atrial natriuretic factor (ANF) negative pressure ventilation (NPV) positive end expiratory pressure (PEEP) |
| title_short |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| title_full |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| title_fullStr |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| title_full_unstemmed |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| title_sort |
Intermittent negative pressure ventilation may increase urine flow in normal subjects |
| dc.creator.none.fl_str_mv |
Dias, Ricardo Marques [UNIFESP] Stabile, Carlos [UNIFESP] Dotto, Pedro [UNIFESP] Jardim, José Roberto [UNIFESP] |
| author |
Dias, Ricardo Marques [UNIFESP] |
| author_facet |
Dias, Ricardo Marques [UNIFESP] Stabile, Carlos [UNIFESP] Dotto, Pedro [UNIFESP] Jardim, José Roberto [UNIFESP] |
| author_role |
author |
| author2 |
Stabile, Carlos [UNIFESP] Dotto, Pedro [UNIFESP] Jardim, José Roberto [UNIFESP] |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
| dc.subject.por.fl_str_mv |
Antidiuretic hormone (ADH) atrial natriuretic factor (ANF) negative pressure ventilation (NPV) positive end expiratory pressure (PEEP) |
| topic |
Antidiuretic hormone (ADH) atrial natriuretic factor (ANF) negative pressure ventilation (NPV) positive end expiratory pressure (PEEP) |
| description |
In order to analyze the effect of intermittent negative pressure ventilation (NPV) on renal function, we studied 20 healthy male volunteers (mean age 29±4.1 years). NPV was performed with an Emerson Chest Respirator Pump, adjusted to a breathing frequency of 10 respirations per minute, with inspiratory time/total respiratory time ratio of 0.4 and negative pressure of 25 cmH2O. The experimental protocol was carried out in two phases of two hours each - spontaneous breathing and NPV breathing. At the end of each phase, urine volume of the whole period was collected as well as venous blood sample for biochemical determinations. During NPV there was significant increase (P<0.05) in urine flow rate (1.43±0.81 to 2.76±1.95 ml/min) as well as in natriuresis (258±201 to 389±175 mcEq/min), kaliuresis (61±45 to 98±49 mcEq/min), fractional sodium excretion (1.38±0.88 to 1.96±0.98%), osmolar clearance (3.13±1.82 to 4.32±1.24 ml/min) and pH (7.37± 0.04 to 7.41±0.07) with unchanged creatinine and free water clearances. We concluded that NPV increases urine flow rate, kaliuresis and natriuresis but the data we have do not allow us to explain the mechanisms underlying such a phenomenon. |
| publishDate |
1994 |
| dc.date.none.fl_str_mv |
1994-06-01 2015-06-14T13:24:26Z 2015-06-14T13:24:26Z |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-31801994000200006 São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 112, n. 2, p. 551-554, 1994. 10.1590/S1516-31801994000200006 S1516-31801994000200006.pdf 1516-3180 S1516-31801994000200006 http://repositorio.unifesp.br/handle/11600/339 |
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ark:/48912/001300002qwg0 |
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http://dx.doi.org/10.1590/S1516-31801994000200006 http://repositorio.unifesp.br/handle/11600/339 |
| identifier_str_mv |
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 112, n. 2, p. 551-554, 1994. 10.1590/S1516-31801994000200006 S1516-31801994000200006.pdf 1516-3180 S1516-31801994000200006 ark:/48912/001300002qwg0 |
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eng |
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eng |
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São Paulo Medical Journal |
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info:eu-repo/semantics/openAccess |
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551-554 application/pdf |
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Associação Paulista de Medicina - APM |
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Associação Paulista de Medicina - APM |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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