Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth

The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. Mor...

ver descrição completa

Detalhes bibliográficos
Autores: Silva, Vandeclécio Lira da, Santos, André Mauricio Ribeiro dos, Blanco, Wilfredo, Souza, Sandro José de
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Recursos:Universidade Federal do Rio Grande do Norte (UFRN)
Repositorio:Repositório Institucional da UFRN
Idioma:inglés
OAI Identifier:oai:repositorio.ufrn.br:123456789/26960
Acesso em linha:https://repositorio.ufrn.br/jspui/handle/123456789/26960
Access Level:acceso abierto
Palavra-chave:Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
id BR_81e5afc8d29db1fe9f2b63cba109a7a2
oai_identifier_str oai:repositorio.ufrn.br:123456789/26960
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadthTranscription Factor Binding Sites (TFBS)transcript factorhuman evolutionexpression breadthThe gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. More than 40% (9,206) of these TFBS-HS are in the vicinity of 1,283 genes. A comparison of the expression pattern of these genes and the corresponding orthologs in chimpanzee and gorilla identified genes differentially expressed in human tissues. These genes show a more divergent expression pattern in the human testis and brain, suggesting a role for positive selection in the fixation of TFBS gains. Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous system. Furthermore, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general. This biased distribution is due to a preferential gain of TFBS in genes with higher expression breadth rather than a shift in the expression pattern after the gain of TFBS.2019-04-23T14:10:50Z2019-04-23T14:10:50Z2019-03-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSILVA, V. L. et al. Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth. Sci. China Life Sci. v. 62, p. 526, mar. 2019. doi: 10.1007/s11427-018-9454-7https://repositorio.ufrn.br/jspui/handle/123456789/2696010.1007/s11427-018-9454-7ark:/41046/001300000nmnzengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessSilva, Vandeclécio Lira daSantos, André Mauricio Ribeiro dosBlanco, WilfredoSouza, Sandro José de2025-05-29T17:19:45Zoai:repositorio.ufrn.br:123456789/26960Repositório InstitucionalPUBhttp://repositorio.ufrn.br/oai/repositorio@bczm.ufrn.bropendoar:2025-05-29T17:19:45Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.none.fl_str_mv Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
spellingShingle Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
Silva, Vandeclécio Lira da
Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
title_short Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_full Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_fullStr Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_full_unstemmed Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
title_sort Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth
dc.creator.none.fl_str_mv Silva, Vandeclécio Lira da
Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
author Silva, Vandeclécio Lira da
author_facet Silva, Vandeclécio Lira da
Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
author_role author
author2 Santos, André Mauricio Ribeiro dos
Blanco, Wilfredo
Souza, Sandro José de
author2_role author
author
author
dc.subject.por.fl_str_mv Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
topic Transcription Factor Binding Sites (TFBS)
transcript factor
human evolution
expression breadth
description The gain of transcription factor binding sites (TFBS) is believed to represent one of the major causes of biological innovation. Here we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage (TFBS-HS), when compared to chimpanzee and gorilla genomes. More than 40% (9,206) of these TFBS-HS are in the vicinity of 1,283 genes. A comparison of the expression pattern of these genes and the corresponding orthologs in chimpanzee and gorilla identified genes differentially expressed in human tissues. These genes show a more divergent expression pattern in the human testis and brain, suggesting a role for positive selection in the fixation of TFBS gains. Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous system. Furthermore, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general. This biased distribution is due to a preferential gain of TFBS in genes with higher expression breadth rather than a shift in the expression pattern after the gain of TFBS.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-23T14:10:50Z
2019-04-23T14:10:50Z
2019-03-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SILVA, V. L. et al. Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth. Sci. China Life Sci. v. 62, p. 526, mar. 2019. doi: 10.1007/s11427-018-9454-7
https://repositorio.ufrn.br/jspui/handle/123456789/26960
10.1007/s11427-018-9454-7
dc.identifier.dark.fl_str_mv ark:/41046/001300000nmnz
identifier_str_mv SILVA, V. L. et al. Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth. Sci. China Life Sci. v. 62, p. 526, mar. 2019. doi: 10.1007/s11427-018-9454-7
10.1007/s11427-018-9454-7
ark:/41046/001300000nmnz
url https://repositorio.ufrn.br/jspui/handle/123456789/26960
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv repositorio@bczm.ufrn.br
_version_ 1853668057367445504
score 15,301629

Registos relacionados