Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat

Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QT...

ver descrição completa

Detalhes bibliográficos
Autores: Rehman, Anisur, Ibrahim, Mohammad, Ansari, Shafeeque Ahmed, Siddiqui, Javed Inam, Ahmad, Sayeed
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Recursos:Universidade de São Paulo (USP)
Repositorio:Brazilian Journal of Pharmaceutical Sciences
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/207911
Acesso em linha:https://www.revistas.usp.br/bjps/article/view/207911
Access Level:acceso abierto
Palavra-chave:Diabetes
Rumex vesicarius
Antioxidant
UPLC-QTOF-MS
id BR_7fd8d7adf2876ea718fbde5b277d7678
oai_identifier_str oai:revistas.usp.br:article/207911
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticratDiabetesRumex vesicariusAntioxidantUPLC-QTOF-MSRumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20791110.1590/s2175-97902022e21032Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/207911/197687Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRehman, AnisurIbrahim, MohammadAnsari, Shafeeque AhmedSiddiqui, Javed InamAhmad, Sayeed2023-08-30T20:09:23Zoai:revistas.usp.br:article/207911Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-30T20:09:23Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
title Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
spellingShingle Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
Rehman, Anisur
Diabetes
Rumex vesicarius
Antioxidant
UPLC-QTOF-MS
title_short Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
title_full Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
title_fullStr Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
title_full_unstemmed Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
title_sort Metabolomic profiling and antidiabetic potential of Rumex vesicarius seed extract in high-fat diet and streptozotocin-induced diabeticrat
dc.creator.none.fl_str_mv Rehman, Anisur
Ibrahim, Mohammad
Ansari, Shafeeque Ahmed
Siddiqui, Javed Inam
Ahmad, Sayeed
author Rehman, Anisur
author_facet Rehman, Anisur
Ibrahim, Mohammad
Ansari, Shafeeque Ahmed
Siddiqui, Javed Inam
Ahmad, Sayeed
author_role author
author2 Ibrahim, Mohammad
Ansari, Shafeeque Ahmed
Siddiqui, Javed Inam
Ahmad, Sayeed
author2_role author
author
author
author
dc.subject.por.fl_str_mv Diabetes
Rumex vesicarius
Antioxidant
UPLC-QTOF-MS
topic Diabetes
Rumex vesicarius
Antioxidant
UPLC-QTOF-MS
description Rumex vesicarius hasbeen extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes.
publishDate 2023
dc.date.none.fl_str_mv 2023-02-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207911
10.1590/s2175-97902022e21032
url https://www.revistas.usp.br/bjps/article/view/207911
identifier_str_mv 10.1590/s2175-97902022e21032
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207911/197687
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1853675626050879488
score 15,301629

Registos relacionados