Metabolic modeling and comparative biochemistry in glyoxylate cycle
Glyoxylate cycle in fatty acid catabolism enhances net production of oxaloacetate, a substrate for gluconeogenesis, in certain bacteria, invertebrates and oilseed in the growth stage. A theoretical model was developed to calculate ATP amount produced in each step of the catabolic pathway, taking int...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Estadual de Maringá (UEM) |
| Repositorio: | Acta Scientiarum Biological Sciences |
| Idioma: | inglés |
| OAI Identifier: | oai:periodicos.uem.br/ojs:article/24597 |
| Acceso en línea: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/24597 |
| Access Level: | acceso abierto |
| Palabra clave: | catabolism energy efficiency acetyl-CoA oxidation Bioquímica |
| Sumario: | Glyoxylate cycle in fatty acid catabolism enhances net production of oxaloacetate, a substrate for gluconeogenesis, in certain bacteria, invertebrates and oilseed in the growth stage. A theoretical model was developed to calculate ATP amount produced in each step of the catabolic pathway, taking into account the fatty acid’s hydrocarbon chain size. Results showed a decrease in energy efficiency in glyoxylate cycle when compared to animal metabolism. Although the glyoxylate cycle provides evolutionary adaptations, it determines a smaller amount of energy produced per carbon atom when compared to animal catabolism of fatty acids. |
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