Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil

National Institutes of Health. Coordenação de Aperfeiçoamento de Ensino Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

Detalhes bibliográficos
Autores: Cruz, Jaqueline S., Nery Jr, Nivison, Sacramento, Gielson A., Victoriano, Renato, Montenegro, Albino L. S., Santana, Juliet O., Costa, Federico, Ko, Albert I., Reis, Mitermayer G., Wunder Jr, Elsio A.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositório:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglês
OAI Identifier:oai:arca.fiocruz.br:icict/60817
Acesso em linha:https://arca.fiocruz.br/handle/icict/60817
Access Level:Acceso aberto
Palavra-chave:Leptospira
Leptospirose
Humano
Pesquisa sorológica
Estreira
Cinética de anticorpos
Leptospirosis
Human
Serosurvey
MAT
Antibody kinetics
id BR_7082452bbe2e53cf9a241d7fe218cedb
oai_identifier_str oai:arca.fiocruz.br:icict/60817
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
title Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
spellingShingle Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
Cruz, Jaqueline S.
Leptospira
Leptospirose
Humano
Pesquisa sorológica
Estreira
Cinética de anticorpos
Leptospira
Leptospirosis
Human
Serosurvey
MAT
Antibody kinetics
Leptospira
Leptospirosis
title_short Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
title_full Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
title_fullStr Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
title_full_unstemmed Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
title_sort Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil
dc.creator.none.fl_str_mv Cruz, Jaqueline S.
Nery Jr, Nivison
Sacramento, Gielson A.
Victoriano, Renato
Montenegro, Albino L. S.
Santana, Juliet O.
Costa, Federico
Ko, Albert I.
Reis, Mitermayer G.
Wunder Jr, Elsio A.
author Cruz, Jaqueline S.
author_facet Cruz, Jaqueline S.
Nery Jr, Nivison
Sacramento, Gielson A.
Victoriano, Renato
Montenegro, Albino L. S.
Santana, Juliet O.
Costa, Federico
Ko, Albert I.
Reis, Mitermayer G.
Wunder Jr, Elsio A.
author_role author
author2 Nery Jr, Nivison
Sacramento, Gielson A.
Victoriano, Renato
Montenegro, Albino L. S.
Santana, Juliet O.
Costa, Federico
Ko, Albert I.
Reis, Mitermayer G.
Wunder Jr, Elsio A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv Leptospira
Leptospirose
Humano
Pesquisa sorológica
Estreira
Cinética de anticorpos
topic Leptospira
Leptospirose
Humano
Pesquisa sorológica
Estreira
Cinética de anticorpos
Leptospira
Leptospirosis
Human
Serosurvey
MAT
Antibody kinetics
Leptospira
Leptospirosis
dc.subject.en.none.fl_str_mv Leptospira
Leptospirosis
Human
Serosurvey
MAT
Antibody kinetics
dc.subject.decs.none.fl_str_mv Leptospira
Leptospirosis
description National Institutes of Health. Coordenação de Aperfeiçoamento de Ensino Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-10-16T18:38:25Z
dc.date.available.fl_str_mv 2023-10-16T18:38:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Jaqueline S. et al. Cruz. Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil. Frontiers in Medicine, v. 9, p. 1-9, 2022.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/60817
dc.identifier.issn.none.fl_str_mv 2296-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2022.862378
identifier_str_mv CRUZ, Jaqueline S. et al. Cruz. Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil. Frontiers in Medicine, v. 9, p. 1-9, 2022.
2296-858X
10.3389/fmed.2022.862378
url https://arca.fiocruz.br/handle/icict/60817
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/b09239a9-2d01-4359-b609-b26e3a9f797e/download
https://arca.fiocruz.br/bitstreams/d88645f6-3f87-43c4-98f0-695efd9e4472/download
https://arca.fiocruz.br/bitstreams/bb957737-e4f4-4107-a011-8d7441617b5a/download
https://arca.fiocruz.br/bitstreams/9e5bedf8-e284-4bae-8a97-28128aac01b0/download
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
c6939077960e36fb32854f5a630b7afb
95f86d7902f8cd027af3549afed790d2
959119b0723a78a3cbe8fc4370dc9e1a
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1853674517411397632
spelling 2023-10-16T18:38:25Z2023-10-16T18:38:25Z2022CRUZ, Jaqueline S. et al. Cruz. Biannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazil. Frontiers in Medicine, v. 9, p. 1-9, 2022.2296-858Xhttps://arca.fiocruz.br/handle/icict/6081710.3389/fmed.2022.862378National Institutes of Health. Coordenação de Aperfeiçoamento de Ensino Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Geografia. Instituto de Geociências. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Geografia. Instituto de Geociências. Salvador, BA, Brasil.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, United States.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, United States.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, United States / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Departamento de Medicina e Patologia Legal. Salvador, BA, Brasil.Ministério da Saúde. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, United States.Introduction: Leptospirosis is a zoonosis with a worldwide spread that leads to clinical manifestations ranging from asymptomatic infection to a life-threatening disease. The immune response is predominantly humoral mediated limited to the infecting serovar. Individuals living in an area endemic for leptospirosis are often exposed to an environment contaminated with leptospires and there is a paucity of information on naturally acquired immunity. In the present study, we evaluated the kinetics of agglutinating antibodies in individuals from an endemic area for leptospirosis in Salvador, Brazil comparing two different intersample collection times. Methods: Between 2017-2018, we carried out a biannual prospective cohort with 2,086 individuals living in an endemic area for leptospirosis in Salvador, Brazil. To compare agglutinating antibody kinetics using microscopic agglutination test (MAT) with different collection times, a subcohort of 72 individuals with quarterly follow-up was carried out in parallel. Results: The results revealed that using a shorter time for intersample collection led to the detection of a higher number of infections and reinfection events. Furthermore, we observed a higher rate of titer decay indicating partial and short protection. However, there was no indication of major changes in risk factors for the disease. Conclusions: We evaluated antibody kinetics among residents of an endemic area for leptospirosis comparing two sample collection times. The constant exposure to the contaminated environment increases the risk for leptospirosis infection with reinfection events being more common than expected. This indicates that the burden of leptospirosis might be underestimated by serological surveys, and further studies are necessary to better characterize the humoral response after infection.engFrontiers MediaLeptospiraLeptospiroseHumanoPesquisa sorológicaEstreiraCinética de anticorposLeptospiraLeptospirosisHumanSerosurveyMATAntibody kineticsLeptospiraLeptospirosisBiannual and quarterly comparison analysis of agglutinating antibody kinetics on a subcohort of individuals exposed to leptospira interrogans in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZCruz, Jaqueline S.Nery Jr, NivisonSacramento, Gielson A.Victoriano, RenatoMontenegro, Albino L. S.Santana, Juliet O.Costa, FedericoKo, Albert I.Reis, Mitermayer G.Wunder Jr, Elsio A.LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/b09239a9-2d01-4359-b609-b26e3a9f797e/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdfCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdfapplication/pdf1552511https://arca.fiocruz.br/bitstreams/d88645f6-3f87-43c4-98f0-695efd9e4472/downloadc6939077960e36fb32854f5a630b7afbMD52trueAnonymousREADTEXTCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdf.txtCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdf.txtExtracted texttext/plain52832https://arca.fiocruz.br/bitstreams/bb957737-e4f4-4107-a011-8d7441617b5a/download95f86d7902f8cd027af3549afed790d2MD57falseAnonymousREADTHUMBNAILCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdf.jpgCruz, J. S. - Biannual and Quarterly Comparison Analysis of Agglutinating.pdf.jpgGenerated Thumbnailimage/jpeg41299https://arca.fiocruz.br/bitstreams/9e5bedf8-e284-4bae-8a97-28128aac01b0/download959119b0723a78a3cbe8fc4370dc9e1aMD58falseAnonymousREADicict/608172025-12-10 14:30:04.963open.accessoai:arca.fiocruz.br:icict/60817https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T17:30:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
score 15,301629

Registros relacionados