Metabolic and inflammatory response after insulin infusion for venous endothelial evaluation
Objective: To evaluate changes in lipid profile, glucose, insulin and inflammatory markers after intravenous infusion of insulin doses used for the assessment of endothelial function. Methods: The sample included 13 healthy volunteers, aged 25 (±4.7) years and body mass index of 24.8 (±2.1) kg/m2. T...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Brasil |
| Institución: | Universidade Nove de Julho (UNINOVE) |
| Repositorio: | Revista Conscientiae Saúde (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.periodicos.uninove.br:article/4583 |
| Acceso en línea: | https://periodicos.uninove.br/saude/article/view/4583 |
| Access Level: | acceso abierto |
| Palabra clave: | Endothelium Glucose Insulin Lipids. Endotélio Glicose Insulina Lipídios. |
| Sumario: | Objective: To evaluate changes in lipid profile, glucose, insulin and inflammatory markers after intravenous infusion of insulin doses used for the assessment of endothelial function. Methods: The sample included 13 healthy volunteers, aged 25 (±4.7) years and body mass index of 24.8 (±2.1) kg/m2. The data collections were performed in 12-hour fasting (basal) and after the infusion of the hormone. Regular insulin (Insunorm R) was infused at a rate of 0.3 mL/min in seven increasing doses (between 2.5 to 100 μU/mL, for six minutes each) totaling 705 μU. Results: The total cholesterol, triglycerides, HDLc, LDLc, glucose, insulin, protein C ultrasensitive and fibrinogen were not modified (p > 0.05) after intravenous infusion of the hormone. Conclusion: These insulin doses may be employed for assessing endothelium-dependent vasodilation in healthy adults. |
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