Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions

2020-05-31

Detalhes bibliográficos
Autores: Quintella, L. P., Passos, S. R. L., Miranda, L. H. M., Cuzzi, T., Barros, M. B. de L., Francesconi-Do-Vale, A. C., Galhardo, M. C. G., Madeira, M. de F., Carvalho, M. H. Figueiredo de, Schubach, A. de O.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/33311
Acesso em linha:https://arca.fiocruz.br/handle/icict/33311
Access Level:acceso abierto
Palavra-chave:American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
id BR_6d7cff7dc0b2f2e45b26741068ccefec
oai_identifier_str oai:arca.fiocruz.br:icict/33311
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
spellingShingle Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
Quintella, L. P.
American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
title_short Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_full Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_fullStr Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_full_unstemmed Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_sort Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
dc.creator.none.fl_str_mv Quintella, L. P.
Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-Do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
author Quintella, L. P.
author_facet Quintella, L. P.
Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-Do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
author_role author
author2 Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-Do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.en.none.fl_str_mv American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
topic American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
description 2020-05-31
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-05-31T13:40:36Z
dc.date.available.fl_str_mv 2019-05-31T13:40:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/33311
dc.identifier.issn.none.fl_str_mv 0007-0963
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2133.2012.11012.x
dc.identifier.eissn.none.fl_str_mv 1365-2133
identifier_str_mv QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.
0007-0963
10.1111/j.1365-2133.2012.11012.x
1365-2133
url https://arca.fiocruz.br/handle/icict/33311
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Willey
publisher.none.fl_str_mv Willey
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/6c8574be-6b96-4601-baba-19562ff9b572/download
https://arca.fiocruz.br/bitstreams/2ac4aac6-916b-468c-9d46-ff6f465b815e/download
https://arca.fiocruz.br/bitstreams/e13c75b2-0823-4e8c-8a15-6cd5c200ac00/download
https://arca.fiocruz.br/bitstreams/65926f69-5c81-4c28-930c-10a8fe41980c/download
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
c8f0306de3ed36fe946f31b462138afd
1136f20b6f39f13a155278cccdffbbe9
94feb2fa9f20dfe06688c146dd62c574
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1853674177188331520
spelling 2019-05-31T13:40:36Z2019-05-31T13:40:36Z2012QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.0007-0963https://arca.fiocruz.br/handle/icict/3331110.1111/j.1365-2133.2012.11012.x1365-2133engWilleyProposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-05-31Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Background: American tegumentary leishmaniasis (ATL) and sporotrichosis exhibitsimilar histopathology and low frequencies of microorganism detection. Objectives: This study seeks to identify microscopic alterations that can distinguish between these diseases.Methods: Haematoxylin and eosin stained slides of 171 ATL and 97 sporotrichosis samples from active cutaneous lesions were examined for histopathological alterations. The lesions were diagnosed by isolating the agent (which was not visible) in culture. An intuitive diagnosis was assigned to each slide. The strength of the association between the histopathological findings and the diagnosis was estimated by an odds ratio, and each finding was graded according to a regression model. A score was assigned to each sample based on the histopathological findings. A study of the interobserver reliability was performed by calculating kappa coefficients of the histopathological findings and intuitive diagnoses. Results: The markers 'macrophage concentration', 'tuberculoid granuloma' and'extracellular matrix degeneration' were associated with ATL. 'Suppurative granu-loma', 'stellate granuloma', 'different types of giant cells', 'granulomas in granu-lation tissue' and 'abscess outside the granuloma' were associated with adiagnosis of sporotrichosis. 'Macrophage concentration' and 'suppurative granuloma' had the highest (substantial and almost perfect, respectively) reliability. The regression model score indicated 92Æ0% accuracy. The intuitive diagnosishad 82Æ5% diagnostic accuracy and substantial reliability. Conclusions: Taking into account the clinical and epidemiological context, some histopathological alterations might be useful for the differential diagnosis between ATL and sporotrichosis cutaneous lesions in cases in which the aetiological agent is not visible.American tegumentary leishmaniasisSporotrichosisSkin lesionsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZQuintella, L. P.Passos, S. R. L.Miranda, L. H. M.Cuzzi, T.Barros, M. B. de L.Francesconi-Do-Vale, A. C.Galhardo, M. C. G.Madeira, M. de F.Carvalho, M. H. Figueiredo deSchubach, A. de O.LICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/6c8574be-6b96-4601-baba-19562ff9b572/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADORIGINALve_Quintella_L_etal_INI_2012.pdfve_Quintella_L_etal_INI_2012.pdfapplication/pdf478215https://arca.fiocruz.br/bitstreams/2ac4aac6-916b-468c-9d46-ff6f465b815e/downloadc8f0306de3ed36fe946f31b462138afdMD52trueAnonymousREAD2020-05-31TEXTve_Quintella_L_etal_INI_2012.pdf.txtve_Quintella_L_etal_INI_2012.pdf.txtExtracted texttext/plain46361https://arca.fiocruz.br/bitstreams/e13c75b2-0823-4e8c-8a15-6cd5c200ac00/download1136f20b6f39f13a155278cccdffbbe9MD511falseAnonymousREAD2020-05-31THUMBNAILve_Quintella_L_etal_INI_2012.pdf.jpgve_Quintella_L_etal_INI_2012.pdf.jpgGenerated Thumbnailimage/jpeg41137https://arca.fiocruz.br/bitstreams/65926f69-5c81-4c28-930c-10a8fe41980c/download94feb2fa9f20dfe06688c146dd62c574MD512falseAnonymousREAD2020-05-31icict/333112025-12-10 13:00:00.563open.accessoai:arca.fiocruz.br:icict/33311https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T16:00Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
score 15,301629

Registos relacionados